| Full name: bone morphogenetic protein 8a | Alias Symbol: OP-2 | ||
| Type: protein-coding gene | Cytoband: 1p34.3 | ||
| Entrez ID: 353500 | HGNC ID: HGNC:21650 | Ensembl Gene: ENSG00000183682 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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BMP8A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04350 | TGF-beta signaling pathway | |
| hsa04390 | Hippo signaling pathway |
Expression of BMP8A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BMP8A | 353500 | 220203_at | 0.3891 | 0.0960 | |
| GSE20347 | BMP8A | 353500 | 220203_at | 0.0120 | 0.8854 | |
| GSE23400 | BMP8A | 353500 | 220203_at | -0.0502 | 0.2970 | |
| GSE26886 | BMP8A | 353500 | 220203_at | 0.0221 | 0.8722 | |
| GSE29001 | BMP8A | 353500 | 220203_at | -0.1182 | 0.4982 | |
| GSE38129 | BMP8A | 353500 | 220203_at | 0.1105 | 0.0703 | |
| GSE45670 | BMP8A | 353500 | 220203_at | 0.1012 | 0.2024 | |
| GSE63941 | BMP8A | 353500 | 220203_at | 0.2484 | 0.1067 | |
| GSE77861 | BMP8A | 353500 | 220203_at | -0.0458 | 0.7921 | |
| GSE97050 | BMP8A | 353500 | A_23_P85922 | 0.9854 | 0.1146 | |
| SRP007169 | BMP8A | 353500 | RNAseq | 4.7745 | 0.0000 | |
| SRP008496 | BMP8A | 353500 | RNAseq | 4.3156 | 0.0000 | |
| SRP064894 | BMP8A | 353500 | RNAseq | 1.3574 | 0.0000 | |
| SRP133303 | BMP8A | 353500 | RNAseq | 1.3002 | 0.0000 | |
| SRP159526 | BMP8A | 353500 | RNAseq | 2.3019 | 0.0000 | |
| SRP193095 | BMP8A | 353500 | RNAseq | 1.1411 | 0.0000 | |
| SRP219564 | BMP8A | 353500 | RNAseq | 0.9125 | 0.0223 | |
| TCGA | BMP8A | 353500 | RNAseq | 0.4889 | 0.0004 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by BMP8A expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of BMP8A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BMP8A | 353500 | 3 | 4 | 23 | |
| GSE20123 | BMP8A | 353500 | 2 | 3 | 25 | |
| GSE43470 | BMP8A | 353500 | 7 | 2 | 34 | |
| GSE46452 | BMP8A | 353500 | 4 | 1 | 54 | |
| GSE47630 | BMP8A | 353500 | 9 | 2 | 29 | |
| GSE54993 | BMP8A | 353500 | 0 | 1 | 69 | |
| GSE54994 | BMP8A | 353500 | 13 | 2 | 38 | |
| GSE60625 | BMP8A | 353500 | 0 | 0 | 11 | |
| GSE74703 | BMP8A | 353500 | 6 | 1 | 29 | |
| GSE74704 | BMP8A | 353500 | 1 | 0 | 19 | |
| TCGA | BMP8A | 353500 | 16 | 16 | 64 |
Total number of gains: 61; Total number of losses: 32; Total Number of normals: 395.
Somatic mutations of BMP8A:
Generating mutation plots.
Highly correlated genes for BMP8A:
Showing top 20/410 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BMP8A | GPR176 | 0.764184 | 3 | 0 | 3 |
| BMP8A | EFTUD2 | 0.726029 | 3 | 0 | 3 |
| BMP8A | ZNF574 | 0.713725 | 3 | 0 | 3 |
| BMP8A | EXOC3L2 | 0.700404 | 3 | 0 | 3 |
| BMP8A | TGFB2 | 0.700364 | 3 | 0 | 3 |
| BMP8A | WDR93 | 0.699293 | 3 | 0 | 3 |
| BMP8A | SLC2A5 | 0.695721 | 3 | 0 | 3 |
| BMP8A | CHPF | 0.693343 | 5 | 0 | 5 |
| BMP8A | TBC1D22A | 0.69309 | 3 | 0 | 3 |
| BMP8A | CD37 | 0.690099 | 3 | 0 | 3 |
| BMP8A | FHL3 | 0.684079 | 3 | 0 | 3 |
| BMP8A | PIAS3 | 0.682396 | 3 | 0 | 3 |
| BMP8A | IRF4 | 0.681729 | 3 | 0 | 3 |
| BMP8A | TBC1D9B | 0.680917 | 3 | 0 | 3 |
| BMP8A | ORAI1 | 0.672509 | 3 | 0 | 3 |
| BMP8A | DPM2 | 0.670122 | 3 | 0 | 3 |
| BMP8A | MYPOP | 0.669834 | 4 | 0 | 3 |
| BMP8A | SDF2L1 | 0.668774 | 3 | 0 | 3 |
| BMP8A | SUCNR1 | 0.666191 | 3 | 0 | 3 |
| BMP8A | VAC14 | 0.666068 | 5 | 0 | 4 |
For details and further investigation, click here
