DPM2

 

Full name: dolichyl-phosphate mannosyltransferase subunit 2, regulatory Alias Symbol: MGC21559|MGC111193
Type: protein-coding gene Cytoband: 9q34.11
Entrez ID: 8818 HGNC ID: HGNC:3006 Ensembl Gene: ENSG00000136908 OMIM ID: 603564
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of DPM2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DPM2 8818 209391_at 0.3992 0.1328
GSE20347 DPM2 8818 209391_at 0.3435 0.0264
GSE23400 DPM2 8818 209391_at 0.4395 0.0000
GSE26886 DPM2 8818 209391_at 0.3694 0.0677
GSE29001 DPM2 8818 209391_at 0.2523 0.2311
GSE38129 DPM2 8818 209391_at 0.4718 0.0003
GSE45670 DPM2 8818 209391_at 0.2948 0.0460
GSE53622 DPM2 8818 60979 0.7282 0.0000
GSE53624 DPM2 8818 60979 0.9071 0.0000
GSE63941 DPM2 8818 209391_at 1.3515 0.0027
GSE77861 DPM2 8818 209391_at 0.3594 0.0577
GSE97050 DPM2 8818 A_23_P217079 0.7076 0.1812
SRP007169 DPM2 8818 RNAseq 0.8159 0.1012
SRP008496 DPM2 8818 RNAseq 0.5136 0.0786
SRP064894 DPM2 8818 RNAseq 0.9820 0.0050
SRP133303 DPM2 8818 RNAseq 0.5788 0.0104
SRP159526 DPM2 8818 RNAseq 0.5376 0.0668
SRP193095 DPM2 8818 RNAseq 0.3560 0.0023
SRP219564 DPM2 8818 RNAseq 0.5259 0.1080
TCGA DPM2 8818 RNAseq -0.0012 0.9854

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by DPM2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DPM2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DPM2 8818 6 9 15
GSE20123 DPM2 8818 6 9 15
GSE43470 DPM2 8818 5 7 31
GSE46452 DPM2 8818 6 13 40
GSE47630 DPM2 8818 3 16 21
GSE54993 DPM2 8818 3 3 64
GSE54994 DPM2 8818 11 8 34
GSE60625 DPM2 8818 0 0 11
GSE74703 DPM2 8818 5 5 26
GSE74704 DPM2 8818 3 7 10
TCGA DPM2 8818 27 25 44

Total number of gains: 75; Total number of losses: 102; Total Number of normals: 311.  

 

Somatic mutations of DPM2:

 

Generating mutation plots.

 

Highly correlated genes for DPM2:

 

Showing top 20/1678 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DPM2PRDM150.839307303
DPM2RAD180.787662303
DPM2ANKRD540.781417303
DPM2TMEM440.752436404
DPM2PSMG30.745061606
DPM2FAM89A0.739604303
DPM2MRPL380.735062505
DPM2EFTUD20.733236707
DPM2ZNF7470.730596303
DPM2MCMBP0.724716404
DPM2ZNF7070.721358303
DPM2NADSYN10.720527303
DPM2NLN0.719949303
DPM2MFSD30.718076505
DPM2NUCKS10.717134303
DPM2RHBDD20.712965706
DPM2DHX370.712513606
DPM2RAB11B0.711762303
DPM2CD220.709711303
DPM2ZC3HC10.707675605

For details and further investigation, click here