| Full name: ORAI calcium release-activated calcium modulator 1 | Alias Symbol: FLJ14466|CRACM1 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 84876 | HGNC ID: HGNC:25896 | Ensembl Gene: ENSG00000276045 | OMIM ID: 610277 |
| Drug and gene relationship at DGIdb | |||
ORAI1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04024 | cAMP signaling pathway | |
| hsa04611 | Platelet activation |
Expression of ORAI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ORAI1 | 84876 | 226531_at | 0.6164 | 0.0505 | |
| GSE26886 | ORAI1 | 84876 | 226531_at | 0.6754 | 0.0016 | |
| GSE45670 | ORAI1 | 84876 | 226531_at | 0.4293 | 0.0086 | |
| GSE63941 | ORAI1 | 84876 | 226531_at | 0.8650 | 0.0007 | |
| GSE77861 | ORAI1 | 84876 | 226531_at | 0.2155 | 0.4208 | |
| GSE97050 | ORAI1 | 84876 | A_24_P146892 | 0.3923 | 0.1836 | |
| SRP007169 | ORAI1 | 84876 | RNAseq | 0.5986 | 0.2385 | |
| SRP008496 | ORAI1 | 84876 | RNAseq | 0.3775 | 0.2735 | |
| SRP064894 | ORAI1 | 84876 | RNAseq | 1.0178 | 0.0021 | |
| SRP133303 | ORAI1 | 84876 | RNAseq | 0.2168 | 0.1506 | |
| SRP159526 | ORAI1 | 84876 | RNAseq | 0.4811 | 0.0449 | |
| SRP193095 | ORAI1 | 84876 | RNAseq | 0.5520 | 0.0009 | |
| SRP219564 | ORAI1 | 84876 | RNAseq | 0.3140 | 0.4181 | |
| TCGA | ORAI1 | 84876 | RNAseq | 0.1064 | 0.0720 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ORAI1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ORAI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ORAI1 | 84876 | 5 | 4 | 21 | |
| GSE20123 | ORAI1 | 84876 | 5 | 4 | 21 | |
| GSE43470 | ORAI1 | 84876 | 2 | 2 | 39 | |
| GSE46452 | ORAI1 | 84876 | 9 | 1 | 49 | |
| GSE47630 | ORAI1 | 84876 | 9 | 3 | 28 | |
| GSE54993 | ORAI1 | 84876 | 0 | 5 | 65 | |
| GSE54994 | ORAI1 | 84876 | 6 | 7 | 40 | |
| GSE60625 | ORAI1 | 84876 | 0 | 0 | 11 | |
| GSE74703 | ORAI1 | 84876 | 2 | 1 | 33 | |
| GSE74704 | ORAI1 | 84876 | 4 | 2 | 14 | |
| TCGA | ORAI1 | 84876 | 21 | 10 | 65 |
Total number of gains: 63; Total number of losses: 39; Total Number of normals: 386.
Somatic mutations of ORAI1:
Generating mutation plots.
Highly correlated genes for ORAI1:
Showing top 20/1352 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ORAI1 | CWF19L1 | 0.824104 | 3 | 0 | 3 |
| ORAI1 | C5orf22 | 0.821465 | 3 | 0 | 3 |
| ORAI1 | HNRNPF | 0.817921 | 3 | 0 | 3 |
| ORAI1 | PRR3 | 0.807817 | 3 | 0 | 3 |
| ORAI1 | ADO | 0.803813 | 3 | 0 | 3 |
| ORAI1 | M6PR | 0.800708 | 4 | 0 | 4 |
| ORAI1 | CDT1 | 0.798126 | 5 | 0 | 5 |
| ORAI1 | MCM10 | 0.793373 | 4 | 0 | 4 |
| ORAI1 | PSMC2 | 0.791517 | 3 | 0 | 3 |
| ORAI1 | CEP41 | 0.789795 | 3 | 0 | 3 |
| ORAI1 | DDX20 | 0.782118 | 3 | 0 | 3 |
| ORAI1 | RPN1 | 0.776522 | 3 | 0 | 3 |
| ORAI1 | WDHD1 | 0.773546 | 4 | 0 | 4 |
| ORAI1 | TEX264 | 0.769774 | 3 | 0 | 3 |
| ORAI1 | CLSPN | 0.768676 | 3 | 0 | 3 |
| ORAI1 | DUS3L | 0.766289 | 3 | 0 | 3 |
| ORAI1 | RFWD3 | 0.763707 | 3 | 0 | 3 |
| ORAI1 | UBIAD1 | 0.761836 | 3 | 0 | 3 |
| ORAI1 | TATDN2 | 0.759038 | 3 | 0 | 3 |
| ORAI1 | ACTL6A | 0.75564 | 5 | 0 | 5 |
For details and further investigation, click here
