VAC14

 

Full name: VAC14 component of PIKFYVE complex Alias Symbol: FLJ10305|ArPIKfyve
Type: protein-coding gene Cytoband: 16q22.1-q22.2
Entrez ID: 55697 HGNC ID: HGNC:25507 Ensembl Gene: ENSG00000103043 OMIM ID: 604632
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of VAC14:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 VAC14 55697 218169_at 0.6526 0.0206
GSE20347 VAC14 55697 218169_at 0.3954 0.0000
GSE23400 VAC14 55697 218169_at 0.2759 0.0000
GSE26886 VAC14 55697 218169_at 0.6454 0.0003
GSE29001 VAC14 55697 218169_at -0.0938 0.6915
GSE38129 VAC14 55697 218169_at 0.3793 0.0001
GSE45670 VAC14 55697 218169_at 0.3156 0.0005
GSE53622 VAC14 55697 30569 0.7084 0.0000
GSE53624 VAC14 55697 89234 0.6956 0.0000
GSE63941 VAC14 55697 218169_at 1.2008 0.0135
GSE77861 VAC14 55697 218169_at 0.5052 0.0242
GSE97050 VAC14 55697 A_23_P77593 0.8604 0.0599
SRP007169 VAC14 55697 RNAseq 0.3146 0.3179
SRP008496 VAC14 55697 RNAseq 0.3279 0.1958
SRP064894 VAC14 55697 RNAseq 0.6482 0.0001
SRP133303 VAC14 55697 RNAseq 0.6747 0.0000
SRP159526 VAC14 55697 RNAseq 0.5895 0.0063
SRP193095 VAC14 55697 RNAseq 0.7835 0.0000
SRP219564 VAC14 55697 RNAseq 0.3655 0.2565
TCGA VAC14 55697 RNAseq 0.0814 0.0744

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by VAC14 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of VAC14:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 VAC14 55697 6 1 23
GSE20123 VAC14 55697 6 1 23
GSE43470 VAC14 55697 2 8 33
GSE46452 VAC14 55697 38 1 20
GSE47630 VAC14 55697 11 8 21
GSE54993 VAC14 55697 2 4 64
GSE54994 VAC14 55697 8 10 35
GSE60625 VAC14 55697 4 0 7
GSE74703 VAC14 55697 2 5 29
GSE74704 VAC14 55697 3 0 17
TCGA VAC14 55697 27 12 57

Total number of gains: 109; Total number of losses: 50; Total Number of normals: 329.  

 

Somatic mutations of VAC14:

 

Generating mutation plots.

 

Highly correlated genes for VAC14:

 

Showing top 20/1614 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
VAC14ZNF3580.770472303
VAC14TRADD0.731865404
VAC14PLEKHG20.729879303
VAC14RHOBTB20.728951303
VAC14CDCA20.719614404
VAC14RILPL10.71945303
VAC14SPNS10.717928404
VAC14SMYD50.71460110010
VAC14ZNF6280.7113504
VAC14EBNA1BP20.709822303
VAC14BANF10.70779912012
VAC14TMEM170A0.706459303
VAC14PSKH10.704382404
VAC14LEMD20.703804404
VAC14TANGO20.702644504
VAC14NSD10.701649303
VAC14SIRPG0.701009303
VAC14SPIRE10.700102303
VAC14MSTO10.699161505
VAC14PROX10.698303404

For details and further investigation, click here