| Full name: G protein-coupled receptor 176 | Alias Symbol: Gm1012 | ||
| Type: protein-coding gene | Cytoband: 15q14-q15.1 | ||
| Entrez ID: 11245 | HGNC ID: HGNC:32370 | Ensembl Gene: ENSG00000166073 | OMIM ID: 612183 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR176:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR176 | 11245 | 227846_at | 0.9259 | 0.2012 | |
| GSE20347 | GPR176 | 11245 | 206673_at | 0.0086 | 0.9248 | |
| GSE23400 | GPR176 | 11245 | 206673_at | -0.0040 | 0.9350 | |
| GSE26886 | GPR176 | 11245 | 227846_at | 1.0436 | 0.0004 | |
| GSE29001 | GPR176 | 11245 | 206673_at | -0.1804 | 0.1725 | |
| GSE38129 | GPR176 | 11245 | 206673_at | -0.0041 | 0.9656 | |
| GSE45670 | GPR176 | 11245 | 227846_at | 0.8617 | 0.0499 | |
| GSE53622 | GPR176 | 11245 | 23246 | 0.7418 | 0.0000 | |
| GSE53624 | GPR176 | 11245 | 23246 | 0.6477 | 0.0000 | |
| GSE63941 | GPR176 | 11245 | 227846_at | -1.8690 | 0.1321 | |
| GSE77861 | GPR176 | 11245 | 227846_at | 0.7213 | 0.1073 | |
| GSE97050 | GPR176 | 11245 | A_23_P37676 | 0.6952 | 0.3164 | |
| SRP007169 | GPR176 | 11245 | RNAseq | 8.2791 | 0.0000 | |
| SRP008496 | GPR176 | 11245 | RNAseq | 6.2127 | 0.0000 | |
| SRP064894 | GPR176 | 11245 | RNAseq | 2.5105 | 0.0000 | |
| SRP133303 | GPR176 | 11245 | RNAseq | 2.3666 | 0.0000 | |
| SRP159526 | GPR176 | 11245 | RNAseq | 2.5776 | 0.0000 | |
| SRP193095 | GPR176 | 11245 | RNAseq | 3.8630 | 0.0000 | |
| SRP219564 | GPR176 | 11245 | RNAseq | 1.6256 | 0.0001 | |
| TCGA | GPR176 | 11245 | RNAseq | 0.9694 | 0.0000 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by GPR176 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR176:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR176 | 11245 | 4 | 5 | 21 | |
| GSE20123 | GPR176 | 11245 | 4 | 6 | 20 | |
| GSE43470 | GPR176 | 11245 | 4 | 6 | 33 | |
| GSE46452 | GPR176 | 11245 | 3 | 7 | 49 | |
| GSE47630 | GPR176 | 11245 | 8 | 11 | 21 | |
| GSE54993 | GPR176 | 11245 | 4 | 6 | 60 | |
| GSE54994 | GPR176 | 11245 | 5 | 7 | 41 | |
| GSE60625 | GPR176 | 11245 | 4 | 0 | 7 | |
| GSE74703 | GPR176 | 11245 | 4 | 5 | 27 | |
| GSE74704 | GPR176 | 11245 | 2 | 3 | 15 | |
| TCGA | GPR176 | 11245 | 11 | 17 | 68 |
Total number of gains: 53; Total number of losses: 73; Total Number of normals: 362.
Somatic mutations of GPR176:
Generating mutation plots.
Highly correlated genes for GPR176:
Showing top 20/524 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR176 | BMP8A | 0.764184 | 3 | 0 | 3 |
| GPR176 | CD40 | 0.761608 | 3 | 0 | 3 |
| GPR176 | NOB1 | 0.721863 | 3 | 0 | 3 |
| GPR176 | VPS35 | 0.679671 | 3 | 0 | 3 |
| GPR176 | MTAP | 0.677363 | 4 | 0 | 4 |
| GPR176 | CETN1 | 0.670014 | 3 | 0 | 3 |
| GPR176 | WDR54 | 0.666716 | 7 | 0 | 7 |
| GPR176 | ZNF114 | 0.666191 | 3 | 0 | 3 |
| GPR176 | SMCHD1 | 0.664265 | 3 | 0 | 3 |
| GPR176 | GATA1 | 0.662861 | 3 | 0 | 3 |
| GPR176 | APH1B | 0.660884 | 7 | 0 | 6 |
| GPR176 | SDF4 | 0.660439 | 7 | 0 | 7 |
| GPR176 | ITGA5 | 0.658249 | 5 | 0 | 3 |
| GPR176 | WDHD1 | 0.658024 | 7 | 0 | 6 |
| GPR176 | CEP128 | 0.65584 | 4 | 0 | 3 |
| GPR176 | RBM18 | 0.65311 | 3 | 0 | 3 |
| GPR176 | ISY1 | 0.64808 | 3 | 0 | 3 |
| GPR176 | LOXL2 | 0.643081 | 7 | 0 | 6 |
| GPR176 | CTHRC1 | 0.64037 | 8 | 0 | 8 |
| GPR176 | STK17B | 0.640312 | 4 | 0 | 4 |
For details and further investigation, click here
