TGFB2

 

Full name: transforming growth factor beta 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 1q41
Entrez ID: 7042 HGNC ID: HGNC:11768 Ensembl Gene: ENSG00000092969 OMIM ID: 190220
Drug and gene relationship at DGIdb

 

TGFB2 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04068FoxO signaling pathway
hsa04110Cell cycle
hsa04350TGF-beta signaling pathway
hsa04380Osteoclast differentiation
hsa04390Hippo signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05152Tuberculosis
hsa05161Hepatitis B
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa05220Chronic myeloid leukemia
hsa05321Inflammatory bowel disease (IBD)

 

Expression of TGFB2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TGFB2 7042 228121_at 0.1656 0.8783
GSE20347 TGFB2 7042 220406_at 0.0475 0.4301
GSE23400 TGFB2 7042 220407_s_at 0.0061 0.8756
GSE26886 TGFB2 7042 228121_at 1.0859 0.0118
GSE29001 TGFB2 7042 220406_at -0.1650 0.3904
GSE38129 TGFB2 7042 220406_at -0.1119 0.0399
GSE45670 TGFB2 7042 228121_at 0.1162 0.8435
GSE53622 TGFB2 7042 428 0.9167 0.0000
GSE53624 TGFB2 7042 428 1.0290 0.0000
GSE63941 TGFB2 7042 228121_at -1.9293 0.1877
GSE77861 TGFB2 7042 220406_at -0.1258 0.3408
GSE97050 TGFB2 7042 A_24_P402438 0.9189 0.2956
SRP007169 TGFB2 7042 RNAseq 1.7921 0.0153
SRP008496 TGFB2 7042 RNAseq 2.3667 0.0000
SRP064894 TGFB2 7042 RNAseq 0.9178 0.0025
SRP133303 TGFB2 7042 RNAseq 1.0893 0.0001
SRP159526 TGFB2 7042 RNAseq 1.1102 0.0001
SRP193095 TGFB2 7042 RNAseq 2.3161 0.0000
SRP219564 TGFB2 7042 RNAseq 0.7951 0.3599
TCGA TGFB2 7042 RNAseq 0.2581 0.1503

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by TGFB2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TGFB2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TGFB2 7042 9 0 21
GSE20123 TGFB2 7042 9 0 21
GSE43470 TGFB2 7042 8 1 34
GSE46452 TGFB2 7042 3 1 55
GSE47630 TGFB2 7042 15 0 25
GSE54993 TGFB2 7042 0 6 64
GSE54994 TGFB2 7042 15 0 38
GSE60625 TGFB2 7042 0 0 11
GSE74703 TGFB2 7042 8 1 27
GSE74704 TGFB2 7042 3 0 17
TCGA TGFB2 7042 45 4 47

Total number of gains: 115; Total number of losses: 13; Total Number of normals: 360.  

 

Somatic mutations of TGFB2:

 

Generating mutation plots.

 

Highly correlated genes for TGFB2:

 

Showing top 20/279 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TGFB2HHLA30.786701303
TGFB2NOTCH40.752539303
TGFB2POU2F20.733774303
TGFB2PLK20.72486303
TGFB2GNG100.713468303
TGFB2NELL10.704831303
TGFB2NAGLU0.704143303
TGFB2FAM131B0.70346303
TGFB2SPECC10.702017404
TGFB2BMP8A0.700364303
TGFB2RNASEH2C0.688337303
TGFB2PCBP30.685261303
TGFB2SNX180.672725303
TGFB2DNER0.671681303
TGFB2SPTAN10.670984303
TGFB2ABHD60.669409303
TGFB2GSC20.663675303
TGFB2LMF20.662311303
TGFB2NES0.661823504
TGFB2MZF10.661232303

For details and further investigation, click here