| Full name: interferon regulatory factor 4 | Alias Symbol: LSIRF | ||
| Type: protein-coding gene | Cytoband: 6p25.3 | ||
| Entrez ID: 3662 | HGNC ID: HGNC:6119 | Ensembl Gene: ENSG00000137265 | OMIM ID: 601900 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of IRF4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRF4 | 3662 | 204562_at | -0.0696 | 0.9409 | |
| GSE20347 | IRF4 | 3662 | 204562_at | 0.1121 | 0.3412 | |
| GSE23400 | IRF4 | 3662 | 204562_at | -0.0803 | 0.0960 | |
| GSE26886 | IRF4 | 3662 | 204562_at | -0.3633 | 0.0142 | |
| GSE29001 | IRF4 | 3662 | 204562_at | -0.0339 | 0.8636 | |
| GSE38129 | IRF4 | 3662 | 204562_at | 0.0202 | 0.9041 | |
| GSE45670 | IRF4 | 3662 | 204562_at | 0.1537 | 0.4415 | |
| GSE53622 | IRF4 | 3662 | 28459 | -0.0562 | 0.7970 | |
| GSE53624 | IRF4 | 3662 | 41767 | -0.7606 | 0.0001 | |
| GSE63941 | IRF4 | 3662 | 204562_at | -0.3265 | 0.3317 | |
| GSE77861 | IRF4 | 3662 | 204562_at | 0.0155 | 0.9382 | |
| GSE97050 | IRF4 | 3662 | A_23_P214360 | 1.2018 | 0.1585 | |
| SRP007169 | IRF4 | 3662 | RNAseq | -0.4576 | 0.5384 | |
| SRP064894 | IRF4 | 3662 | RNAseq | 0.5433 | 0.1737 | |
| SRP133303 | IRF4 | 3662 | RNAseq | 0.0260 | 0.9515 | |
| SRP159526 | IRF4 | 3662 | RNAseq | 0.4652 | 0.5878 | |
| SRP193095 | IRF4 | 3662 | RNAseq | -0.2437 | 0.5414 | |
| SRP219564 | IRF4 | 3662 | RNAseq | 0.8755 | 0.1396 | |
| TCGA | IRF4 | 3662 | RNAseq | -0.4523 | 0.0645 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IRF4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IRF4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRF4 | 3662 | 3 | 5 | 22 | |
| GSE20123 | IRF4 | 3662 | 3 | 5 | 22 | |
| GSE43470 | IRF4 | 3662 | 8 | 2 | 33 | |
| GSE46452 | IRF4 | 3662 | 1 | 10 | 48 | |
| GSE47630 | IRF4 | 3662 | 7 | 8 | 25 | |
| GSE54993 | IRF4 | 3662 | 1 | 3 | 66 | |
| GSE54994 | IRF4 | 3662 | 9 | 2 | 42 | |
| GSE60625 | IRF4 | 3662 | 0 | 1 | 10 | |
| GSE74703 | IRF4 | 3662 | 7 | 2 | 27 | |
| GSE74704 | IRF4 | 3662 | 2 | 2 | 16 | |
| TCGA | IRF4 | 3662 | 16 | 29 | 51 |
Total number of gains: 57; Total number of losses: 69; Total Number of normals: 362.
Somatic mutations of IRF4:
Generating mutation plots.
Highly correlated genes for IRF4:
Showing top 20/394 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRF4 | BTLA | 0.757975 | 6 | 0 | 6 |
| IRF4 | POU2AF1 | 0.734982 | 4 | 0 | 3 |
| IRF4 | BLK | 0.72597 | 5 | 0 | 5 |
| IRF4 | CHST5 | 0.725541 | 3 | 0 | 3 |
| IRF4 | LZTS1 | 0.719724 | 4 | 0 | 4 |
| IRF4 | P2RY8 | 0.716275 | 5 | 0 | 4 |
| IRF4 | FCRLA | 0.709032 | 6 | 0 | 5 |
| IRF4 | CLEC17A | 0.707465 | 3 | 0 | 3 |
| IRF4 | LINC01215 | 0.705137 | 5 | 0 | 4 |
| IRF4 | PARP15 | 0.703583 | 5 | 0 | 5 |
| IRF4 | TAGAP | 0.701874 | 5 | 0 | 5 |
| IRF4 | CD5 | 0.701631 | 6 | 0 | 6 |
| IRF4 | RBP5 | 0.698945 | 4 | 0 | 4 |
| IRF4 | MEI1 | 0.697129 | 5 | 0 | 4 |
| IRF4 | CD180 | 0.693109 | 9 | 0 | 8 |
| IRF4 | GNGT2 | 0.692464 | 4 | 0 | 4 |
| IRF4 | TIGIT | 0.685961 | 4 | 0 | 3 |
| IRF4 | SNX20 | 0.684303 | 6 | 0 | 6 |
| IRF4 | IKZF1 | 0.684122 | 9 | 0 | 8 |
| IRF4 | FCRL5 | 0.682433 | 7 | 0 | 5 |
For details and further investigation, click here
