BEND3

 

Full name: BEN domain containing 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 6q21
Entrez ID: 57673 HGNC ID: HGNC:23040 Ensembl Gene: ENSG00000178409 OMIM ID: 616374
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of BEND3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BEND3 57673 227920_at 0.9904 0.0336
GSE26886 BEND3 57673 227920_at 0.9203 0.0003
GSE45670 BEND3 57673 227920_at 0.8269 0.0000
GSE53622 BEND3 57673 17805 0.5265 0.0000
GSE53624 BEND3 57673 76587 0.8144 0.0000
GSE63941 BEND3 57673 227920_at 0.6681 0.0268
GSE77861 BEND3 57673 227920_at 0.5745 0.0007
GSE97050 BEND3 57673 A_33_P3396646 0.6037 0.1939
SRP007169 BEND3 57673 RNAseq 0.9833 0.0301
SRP008496 BEND3 57673 RNAseq 0.8910 0.0017
SRP064894 BEND3 57673 RNAseq 0.6268 0.0087
SRP133303 BEND3 57673 RNAseq 0.9083 0.0001
SRP159526 BEND3 57673 RNAseq 0.9956 0.0018
SRP193095 BEND3 57673 RNAseq 0.5421 0.0081
SRP219564 BEND3 57673 RNAseq 1.1139 0.0571
TCGA BEND3 57673 RNAseq 0.0433 0.5693

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by BEND3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BEND3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BEND3 57673 2 3 25
GSE20123 BEND3 57673 2 2 26
GSE43470 BEND3 57673 3 1 39
GSE46452 BEND3 57673 2 11 46
GSE47630 BEND3 57673 9 4 27
GSE54993 BEND3 57673 3 2 65
GSE54994 BEND3 57673 8 12 33
GSE60625 BEND3 57673 0 2 9
GSE74703 BEND3 57673 2 1 33
GSE74704 BEND3 57673 0 0 20
TCGA BEND3 57673 5 24 67

Total number of gains: 36; Total number of losses: 62; Total Number of normals: 390.  

 

Somatic mutations of BEND3:

 

Generating mutation plots.

 

Highly correlated genes for BEND3:

 

Showing top 20/757 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BEND3HOMER10.787173505
BEND3KLHL260.773243303
BEND3PNPT10.769833606
BEND3FEN10.769113504
BEND3MIIP0.767212303
BEND3CPNE70.764163303
BEND3LONP10.756897706
BEND3HOXC90.755652606
BEND3FLAD10.753493707
BEND3RBM280.750659605
BEND3FAM24B0.746917303
BEND3LRWD10.742456303
BEND3BMP8B0.740015605
BEND3IRAK10.739976606
BEND3POLD10.736594606
BEND3CPAMD80.734697303
BEND3PHKA20.734259303
BEND3ALKBH50.732149303
BEND3KIF4A0.730883706
BEND3FBRSL10.72973605

For details and further investigation, click here