| Full name: bromodomain containing 2 | Alias Symbol: KIAA9001|RING3|D6S113E|NAT|FSRG1 | ||
| Type: protein-coding gene | Cytoband: 6p21.32 | ||
| Entrez ID: 6046 | HGNC ID: HGNC:1103 | Ensembl Gene: ENSG00000204256 | OMIM ID: 601540 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of BRD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRD2 | 6046 | 214911_s_at | 0.5020 | 0.5934 | |
| GSE20347 | BRD2 | 6046 | 214911_s_at | 0.2842 | 0.0580 | |
| GSE23400 | BRD2 | 6046 | 208685_x_at | 0.2327 | 0.0115 | |
| GSE26886 | BRD2 | 6046 | 214911_s_at | 0.2750 | 0.0976 | |
| GSE29001 | BRD2 | 6046 | 214911_s_at | 0.2249 | 0.4595 | |
| GSE38129 | BRD2 | 6046 | 214911_s_at | 0.3060 | 0.0060 | |
| GSE45670 | BRD2 | 6046 | 214911_s_at | 0.5623 | 0.0006 | |
| GSE53622 | BRD2 | 6046 | 65706 | 0.2513 | 0.0000 | |
| GSE53624 | BRD2 | 6046 | 65706 | 0.4634 | 0.0000 | |
| GSE63941 | BRD2 | 6046 | 214911_s_at | -0.0435 | 0.8772 | |
| GSE77861 | BRD2 | 6046 | 214911_s_at | 0.4259 | 0.1894 | |
| GSE97050 | BRD2 | 6046 | A_24_P307014 | -0.0756 | 0.7545 | |
| SRP007169 | BRD2 | 6046 | RNAseq | 0.6970 | 0.0418 | |
| SRP008496 | BRD2 | 6046 | RNAseq | 0.5653 | 0.0085 | |
| SRP064894 | BRD2 | 6046 | RNAseq | 0.0238 | 0.8543 | |
| SRP133303 | BRD2 | 6046 | RNAseq | 0.1687 | 0.2531 | |
| SRP159526 | BRD2 | 6046 | RNAseq | 0.1752 | 0.3491 | |
| SRP193095 | BRD2 | 6046 | RNAseq | 0.1340 | 0.1914 | |
| SRP219564 | BRD2 | 6046 | RNAseq | -0.0358 | 0.8664 | |
| TCGA | BRD2 | 6046 | RNAseq | -0.0127 | 0.7403 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BRD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BRD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRD2 | 6046 | 5 | 0 | 25 | |
| GSE20123 | BRD2 | 6046 | 5 | 0 | 25 | |
| GSE43470 | BRD2 | 6046 | 5 | 1 | 37 | |
| GSE46452 | BRD2 | 6046 | 2 | 9 | 48 | |
| GSE47630 | BRD2 | 6046 | 8 | 4 | 28 | |
| GSE54993 | BRD2 | 6046 | 3 | 1 | 66 | |
| GSE54994 | BRD2 | 6046 | 11 | 4 | 38 | |
| GSE60625 | BRD2 | 6046 | 1 | 0 | 10 | |
| GSE74703 | BRD2 | 6046 | 5 | 0 | 31 | |
| GSE74704 | BRD2 | 6046 | 2 | 0 | 18 | |
| TCGA | BRD2 | 6046 | 16 | 16 | 64 |
Total number of gains: 63; Total number of losses: 35; Total Number of normals: 390.
Somatic mutations of BRD2:
Generating mutation plots.
Highly correlated genes for BRD2:
Showing top 20/341 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRD2 | TAF3 | 0.827526 | 3 | 0 | 3 |
| BRD2 | CCDC150 | 0.814583 | 3 | 0 | 3 |
| BRD2 | ZNF397 | 0.808353 | 3 | 0 | 3 |
| BRD2 | KLHL20 | 0.784478 | 3 | 0 | 3 |
| BRD2 | SLC26A11 | 0.781027 | 3 | 0 | 3 |
| BRD2 | CBX5 | 0.778914 | 3 | 0 | 3 |
| BRD2 | FAM20B | 0.77409 | 3 | 0 | 3 |
| BRD2 | ARID2 | 0.745179 | 3 | 0 | 3 |
| BRD2 | SAFB2 | 0.742432 | 5 | 0 | 5 |
| BRD2 | FNBP4 | 0.74243 | 3 | 0 | 3 |
| BRD2 | ZNF251 | 0.741108 | 3 | 0 | 3 |
| BRD2 | CHCHD7 | 0.739416 | 3 | 0 | 3 |
| BRD2 | SEC61A2 | 0.723897 | 3 | 0 | 3 |
| BRD2 | RYBP | 0.723496 | 3 | 0 | 3 |
| BRD2 | TMEM150A | 0.717854 | 3 | 0 | 3 |
| BRD2 | ANKRD17 | 0.708815 | 5 | 0 | 4 |
| BRD2 | XRCC1 | 0.705518 | 3 | 0 | 3 |
| BRD2 | NUDT11 | 0.704483 | 3 | 0 | 3 |
| BRD2 | PTOV1 | 0.699343 | 4 | 0 | 3 |
| BRD2 | BAP1 | 0.693655 | 3 | 0 | 3 |
For details and further investigation, click here
