| Full name: SEC61 translocon alpha 2 subunit | Alias Symbol: FLJ10578 | ||
| Type: protein-coding gene | Cytoband: 10p14 | ||
| Entrez ID: 55176 | HGNC ID: HGNC:17702 | Ensembl Gene: ENSG00000065665 | OMIM ID: 618271 |
| Drug and gene relationship at DGIdb | |||
Expression of SEC61A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEC61A2 | 55176 | 219499_at | 0.6486 | 0.0443 | |
| GSE20347 | SEC61A2 | 55176 | 219499_at | 0.4370 | 0.0040 | |
| GSE23400 | SEC61A2 | 55176 | 219499_at | 0.0994 | 0.0318 | |
| GSE26886 | SEC61A2 | 55176 | 219499_at | 0.4384 | 0.0434 | |
| GSE29001 | SEC61A2 | 55176 | 219499_at | 0.5368 | 0.0698 | |
| GSE38129 | SEC61A2 | 55176 | 219499_at | 0.5318 | 0.0000 | |
| GSE45670 | SEC61A2 | 55176 | 219499_at | 0.6856 | 0.0002 | |
| GSE53622 | SEC61A2 | 55176 | 40179 | 0.6011 | 0.0000 | |
| GSE53624 | SEC61A2 | 55176 | 40179 | 0.5743 | 0.0000 | |
| GSE63941 | SEC61A2 | 55176 | 219499_at | -0.7455 | 0.1281 | |
| GSE77861 | SEC61A2 | 55176 | 219499_at | 0.0766 | 0.5633 | |
| GSE97050 | SEC61A2 | 55176 | A_24_P415280 | 0.3633 | 0.1554 | |
| SRP007169 | SEC61A2 | 55176 | RNAseq | 0.1469 | 0.7789 | |
| SRP064894 | SEC61A2 | 55176 | RNAseq | 0.2716 | 0.1113 | |
| SRP133303 | SEC61A2 | 55176 | RNAseq | 0.1434 | 0.3084 | |
| SRP159526 | SEC61A2 | 55176 | RNAseq | 0.5928 | 0.0157 | |
| SRP193095 | SEC61A2 | 55176 | RNAseq | 0.2708 | 0.0139 | |
| SRP219564 | SEC61A2 | 55176 | RNAseq | -0.0006 | 0.9983 | |
| TCGA | SEC61A2 | 55176 | RNAseq | 0.1527 | 0.0879 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SEC61A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEC61A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEC61A2 | 55176 | 6 | 7 | 17 | |
| GSE20123 | SEC61A2 | 55176 | 6 | 6 | 18 | |
| GSE43470 | SEC61A2 | 55176 | 3 | 5 | 35 | |
| GSE46452 | SEC61A2 | 55176 | 2 | 14 | 43 | |
| GSE47630 | SEC61A2 | 55176 | 6 | 14 | 20 | |
| GSE54993 | SEC61A2 | 55176 | 11 | 0 | 59 | |
| GSE54994 | SEC61A2 | 55176 | 4 | 10 | 39 | |
| GSE60625 | SEC61A2 | 55176 | 0 | 0 | 11 | |
| GSE74703 | SEC61A2 | 55176 | 2 | 3 | 31 | |
| GSE74704 | SEC61A2 | 55176 | 1 | 5 | 14 | |
| TCGA | SEC61A2 | 55176 | 19 | 25 | 52 |
Total number of gains: 60; Total number of losses: 89; Total Number of normals: 339.
Somatic mutations of SEC61A2:
Generating mutation plots.
Highly correlated genes for SEC61A2:
Showing top 20/1003 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEC61A2 | SYCP2 | 0.75327 | 3 | 0 | 3 |
| SEC61A2 | BRD2 | 0.723897 | 3 | 0 | 3 |
| SEC61A2 | USP36 | 0.716292 | 4 | 0 | 4 |
| SEC61A2 | POLR1A | 0.715384 | 3 | 0 | 3 |
| SEC61A2 | GFPT2 | 0.715286 | 3 | 0 | 3 |
| SEC61A2 | MTBP | 0.713365 | 4 | 0 | 4 |
| SEC61A2 | PDCD2L | 0.712867 | 5 | 0 | 4 |
| SEC61A2 | PRPF40A | 0.711874 | 3 | 0 | 3 |
| SEC61A2 | GTPBP8 | 0.710343 | 3 | 0 | 3 |
| SEC61A2 | MND1 | 0.708572 | 3 | 0 | 3 |
| SEC61A2 | KLHL7 | 0.706068 | 4 | 0 | 4 |
| SEC61A2 | PNPLA6 | 0.704373 | 3 | 0 | 3 |
| SEC61A2 | C12orf45 | 0.701678 | 4 | 0 | 3 |
| SEC61A2 | RIOK1 | 0.698993 | 4 | 0 | 3 |
| SEC61A2 | ACAD11 | 0.696549 | 3 | 0 | 3 |
| SEC61A2 | PAK1 | 0.696017 | 3 | 0 | 3 |
| SEC61A2 | PPP1R16A | 0.695294 | 4 | 0 | 3 |
| SEC61A2 | KIAA2013 | 0.690537 | 3 | 0 | 3 |
| SEC61A2 | TMC7 | 0.68703 | 4 | 0 | 4 |
| SEC61A2 | NAA25 | 0.686207 | 3 | 0 | 3 |
For details and further investigation, click here
