BAP1

 

Full name: BRCA1 associated protein 1 Alias Symbol: hucep-6|KIAA0272|UCHL2
Type: protein-coding gene Cytoband: 3p21.1
Entrez ID: 8314 HGNC ID: HGNC:950 Ensembl Gene: ENSG00000163930 OMIM ID: 603089
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 94/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of BAP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BAP1 8314 201419_at 0.6417 0.0813
GSE20347 BAP1 8314 201419_at -0.0180 0.8920
GSE23400 BAP1 8314 201419_at 0.0683 0.2556
GSE26886 BAP1 8314 201419_at -0.1838 0.1446
GSE29001 BAP1 8314 201419_at 0.0330 0.9178
GSE38129 BAP1 8314 201419_at 0.0629 0.5321
GSE45670 BAP1 8314 201419_at 0.1729 0.1073
GSE53622 BAP1 8314 1135 0.1377 0.0801
GSE53624 BAP1 8314 1135 0.1942 0.0074
GSE63941 BAP1 8314 201419_at -0.2249 0.5423
GSE77861 BAP1 8314 201419_at 0.1428 0.4858
GSE97050 BAP1 8314 A_23_P259012 0.2025 0.3784
SRP007169 BAP1 8314 RNAseq 2.0743 0.0008
SRP008496 BAP1 8314 RNAseq 1.5292 0.0014
SRP064894 BAP1 8314 RNAseq 0.1439 0.3096
SRP133303 BAP1 8314 RNAseq -0.1554 0.3832
SRP159526 BAP1 8314 RNAseq 0.0286 0.9297
SRP193095 BAP1 8314 RNAseq 0.0751 0.4758
SRP219564 BAP1 8314 RNAseq -0.2865 0.1066
TCGA BAP1 8314 RNAseq -0.0365 0.4216

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by BAP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BAP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BAP1 8314 0 18 12
GSE20123 BAP1 8314 0 19 11
GSE43470 BAP1 8314 0 18 25
GSE46452 BAP1 8314 2 17 40
GSE47630 BAP1 8314 1 24 15
GSE54993 BAP1 8314 6 2 62
GSE54994 BAP1 8314 0 33 20
GSE60625 BAP1 8314 5 0 6
GSE74703 BAP1 8314 0 14 22
GSE74704 BAP1 8314 0 12 8
TCGA BAP1 8314 0 78 18

Total number of gains: 14; Total number of losses: 235; Total Number of normals: 239.  

 

Somatic mutations of BAP1:

 

Generating mutation plots.

 

Highly correlated genes for BAP1:

 

Showing top 20/315 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BAP1MSH20.779338303
BAP1ORAI10.75154403
BAP1SNRPC0.749953303
BAP1SLC39A10.746378303
BAP1SCAF40.745215303
BAP1DSCC10.742349303
BAP1SSH10.735705303
BAP1TSEN150.724423303
BAP1CBL0.719178303
BAP1RAB320.715772303
BAP1POGK0.710407403
BAP1SRXN10.706426303
BAP1HEATR10.701776403
BAP1TMEM110.699907404
BAP1VEGFB0.69867303
BAP1BRD20.693655303
BAP1ARF30.691878303
BAP1ZNF180.689154403
BAP1TARBP10.687347504
BAP1C1orf2260.687172303

For details and further investigation, click here