| Full name: chromobox 5 | Alias Symbol: HP1Hs-alpha|HP1|HP1-ALPHA | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 23468 | HGNC ID: HGNC:1555 | Ensembl Gene: ENSG00000094916 | OMIM ID: 604478 |
| Drug and gene relationship at DGIdb | |||
Expression of CBX5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBX5 | 23468 | 226085_at | 0.7866 | 0.3527 | |
| GSE20347 | CBX5 | 23468 | 212126_at | 0.2124 | 0.3551 | |
| GSE23400 | CBX5 | 23468 | 212126_at | 0.1815 | 0.0281 | |
| GSE26886 | CBX5 | 23468 | 226085_at | 0.1124 | 0.7695 | |
| GSE29001 | CBX5 | 23468 | 212126_at | 0.2350 | 0.4925 | |
| GSE38129 | CBX5 | 23468 | 212126_at | 0.1647 | 0.3566 | |
| GSE45670 | CBX5 | 23468 | 226085_at | -0.4306 | 0.1478 | |
| GSE53622 | CBX5 | 23468 | 58815 | 0.1800 | 0.0171 | |
| GSE53624 | CBX5 | 23468 | 58815 | 0.3166 | 0.0000 | |
| GSE63941 | CBX5 | 23468 | 226085_at | 2.0111 | 0.0424 | |
| GSE77861 | CBX5 | 23468 | 226085_at | 0.8423 | 0.1685 | |
| GSE97050 | CBX5 | 23468 | A_23_P2355 | -0.1325 | 0.7067 | |
| SRP007169 | CBX5 | 23468 | RNAseq | 2.0518 | 0.0004 | |
| SRP008496 | CBX5 | 23468 | RNAseq | 1.6081 | 0.0000 | |
| SRP064894 | CBX5 | 23468 | RNAseq | 0.3661 | 0.0785 | |
| SRP133303 | CBX5 | 23468 | RNAseq | 0.3296 | 0.1755 | |
| SRP159526 | CBX5 | 23468 | RNAseq | 0.3583 | 0.4636 | |
| SRP193095 | CBX5 | 23468 | RNAseq | 0.2925 | 0.0308 | |
| SRP219564 | CBX5 | 23468 | RNAseq | 0.5703 | 0.1232 | |
| TCGA | CBX5 | 23468 | RNAseq | -0.0315 | 0.5999 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CBX5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CBX5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBX5 | 23468 | 4 | 1 | 25 | |
| GSE20123 | CBX5 | 23468 | 4 | 1 | 25 | |
| GSE43470 | CBX5 | 23468 | 3 | 0 | 40 | |
| GSE46452 | CBX5 | 23468 | 7 | 1 | 51 | |
| GSE47630 | CBX5 | 23468 | 10 | 2 | 28 | |
| GSE54993 | CBX5 | 23468 | 0 | 5 | 65 | |
| GSE54994 | CBX5 | 23468 | 4 | 1 | 48 | |
| GSE60625 | CBX5 | 23468 | 0 | 0 | 11 | |
| GSE74703 | CBX5 | 23468 | 3 | 0 | 33 | |
| GSE74704 | CBX5 | 23468 | 3 | 1 | 16 | |
| TCGA | CBX5 | 23468 | 15 | 11 | 70 |
Total number of gains: 53; Total number of losses: 23; Total Number of normals: 412.
Somatic mutations of CBX5:
Generating mutation plots.
Highly correlated genes for CBX5:
Showing top 20/373 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBX5 | ZNF124 | 0.866578 | 3 | 0 | 3 |
| CBX5 | TIPRL | 0.788277 | 3 | 0 | 3 |
| CBX5 | SSBP4 | 0.785347 | 3 | 0 | 3 |
| CBX5 | BRD2 | 0.778914 | 3 | 0 | 3 |
| CBX5 | WWP1 | 0.773642 | 3 | 0 | 3 |
| CBX5 | WDR70 | 0.768837 | 3 | 0 | 3 |
| CBX5 | ZNF260 | 0.768639 | 3 | 0 | 3 |
| CBX5 | MRPS6 | 0.755925 | 3 | 0 | 3 |
| CBX5 | SLC25A33 | 0.755386 | 3 | 0 | 3 |
| CBX5 | NUFIP2 | 0.749898 | 3 | 0 | 3 |
| CBX5 | B3GALNT2 | 0.748216 | 3 | 0 | 3 |
| CBX5 | CRTC2 | 0.746427 | 3 | 0 | 3 |
| CBX5 | ZFYVE27 | 0.726251 | 3 | 0 | 3 |
| CBX5 | DENND4B | 0.724534 | 3 | 0 | 3 |
| CBX5 | ZNF496 | 0.723421 | 4 | 0 | 3 |
| CBX5 | NOM1 | 0.722192 | 3 | 0 | 3 |
| CBX5 | CHD4 | 0.720755 | 3 | 0 | 3 |
| CBX5 | PDCD2L | 0.716236 | 3 | 0 | 3 |
| CBX5 | ZNF740 | 0.714057 | 3 | 0 | 3 |
| CBX5 | VPS72 | 0.712593 | 5 | 0 | 5 |
For details and further investigation, click here
