| Full name: bromodomain containing 3 | Alias Symbol: RING3L|ORFX|KIAA0043 | ||
| Type: protein-coding gene | Cytoband: 9q34.2 | ||
| Entrez ID: 8019 | HGNC ID: HGNC:1104 | Ensembl Gene: ENSG00000169925 | OMIM ID: 601541 |
| Drug and gene relationship at DGIdb | |||
Expression of BRD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BRD3 | 8019 | 203825_at | 0.5837 | 0.3540 | |
| GSE20347 | BRD3 | 8019 | 203825_at | 0.3346 | 0.0427 | |
| GSE23400 | BRD3 | 8019 | 203825_at | 0.3537 | 0.0001 | |
| GSE26886 | BRD3 | 8019 | 212547_at | 0.7969 | 0.0010 | |
| GSE29001 | BRD3 | 8019 | 203825_at | 0.5140 | 0.0592 | |
| GSE38129 | BRD3 | 8019 | 203825_at | 0.2936 | 0.1054 | |
| GSE45670 | BRD3 | 8019 | 203825_at | 0.0775 | 0.7557 | |
| GSE53622 | BRD3 | 8019 | 144636 | -1.4347 | 0.0000 | |
| GSE53624 | BRD3 | 8019 | 129982 | 0.6010 | 0.0000 | |
| GSE63941 | BRD3 | 8019 | 203825_at | 0.7494 | 0.0943 | |
| GSE77861 | BRD3 | 8019 | 203825_at | 0.8476 | 0.0020 | |
| GSE97050 | BRD3 | 8019 | A_33_P3240674 | 0.0406 | 0.8726 | |
| SRP007169 | BRD3 | 8019 | RNAseq | 2.5060 | 0.0000 | |
| SRP008496 | BRD3 | 8019 | RNAseq | 1.6239 | 0.0004 | |
| SRP064894 | BRD3 | 8019 | RNAseq | 0.6588 | 0.0002 | |
| SRP133303 | BRD3 | 8019 | RNAseq | 0.2306 | 0.1353 | |
| SRP159526 | BRD3 | 8019 | RNAseq | 0.6823 | 0.0035 | |
| SRP193095 | BRD3 | 8019 | RNAseq | 0.4405 | 0.0007 | |
| SRP219564 | BRD3 | 8019 | RNAseq | 0.1677 | 0.6354 | |
| TCGA | BRD3 | 8019 | RNAseq | 0.0708 | 0.1906 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by BRD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BRD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BRD3 | 8019 | 4 | 7 | 19 | |
| GSE20123 | BRD3 | 8019 | 4 | 7 | 19 | |
| GSE43470 | BRD3 | 8019 | 4 | 7 | 32 | |
| GSE46452 | BRD3 | 8019 | 6 | 13 | 40 | |
| GSE47630 | BRD3 | 8019 | 6 | 15 | 19 | |
| GSE54993 | BRD3 | 8019 | 3 | 3 | 64 | |
| GSE54994 | BRD3 | 8019 | 12 | 9 | 32 | |
| GSE60625 | BRD3 | 8019 | 0 | 0 | 11 | |
| GSE74703 | BRD3 | 8019 | 4 | 5 | 27 | |
| GSE74704 | BRD3 | 8019 | 2 | 5 | 13 | |
| TCGA | BRD3 | 8019 | 28 | 26 | 42 |
Total number of gains: 73; Total number of losses: 97; Total Number of normals: 318.
Somatic mutations of BRD3:
Generating mutation plots.
Highly correlated genes for BRD3:
Showing top 20/222 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BRD3 | CRTC2 | 0.706946 | 4 | 0 | 3 |
| BRD3 | RILPL1 | 0.677513 | 4 | 0 | 3 |
| BRD3 | ZNF567 | 0.677334 | 3 | 0 | 3 |
| BRD3 | LRRC58 | 0.675835 | 3 | 0 | 3 |
| BRD3 | TNFAIP8L1 | 0.673627 | 4 | 0 | 4 |
| BRD3 | PKNOX1 | 0.671015 | 3 | 0 | 3 |
| BRD3 | LINC00674 | 0.662384 | 3 | 0 | 3 |
| BRD3 | TMEM63B | 0.657831 | 3 | 0 | 3 |
| BRD3 | GGT7 | 0.657078 | 4 | 0 | 4 |
| BRD3 | ZSCAN21 | 0.656351 | 4 | 0 | 4 |
| BRD3 | LRRC69 | 0.652382 | 3 | 0 | 3 |
| BRD3 | ZNF574 | 0.641108 | 6 | 0 | 5 |
| BRD3 | NCOR2 | 0.639231 | 10 | 0 | 7 |
| BRD3 | WDR81 | 0.636504 | 4 | 0 | 3 |
| BRD3 | ASB2 | 0.635406 | 4 | 0 | 4 |
| BRD3 | FRA10AC1 | 0.633834 | 3 | 0 | 3 |
| BRD3 | GTF3C5 | 0.633486 | 6 | 0 | 4 |
| BRD3 | LRRC14 | 0.628213 | 5 | 0 | 4 |
| BRD3 | AIMP2 | 0.626545 | 3 | 0 | 3 |
| BRD3 | IRF9 | 0.62613 | 4 | 0 | 3 |
For details and further investigation, click here
