| Full name: ankyrin repeat and SOCS box containing 2 | Alias Symbol: ASB-2 | ||
| Type: protein-coding gene | Cytoband: 14q32.12 | ||
| Entrez ID: 51676 | HGNC ID: HGNC:16012 | Ensembl Gene: ENSG00000100628 | OMIM ID: 605759 |
| Drug and gene relationship at DGIdb | |||
Expression of ASB2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ASB2 | 51676 | 227915_at | 0.2923 | 0.8030 | |
| GSE26886 | ASB2 | 51676 | 227915_at | 0.7098 | 0.0004 | |
| GSE45670 | ASB2 | 51676 | 227915_at | -0.0399 | 0.9379 | |
| GSE53622 | ASB2 | 51676 | 115654 | -0.8414 | 0.0001 | |
| GSE53624 | ASB2 | 51676 | 115654 | -0.4599 | 0.0025 | |
| GSE63941 | ASB2 | 51676 | 227915_at | 0.7554 | 0.4656 | |
| GSE77861 | ASB2 | 51676 | 227915_at | 0.4729 | 0.3341 | |
| GSE97050 | ASB2 | 51676 | A_23_P205370 | -0.7446 | 0.2507 | |
| SRP007169 | ASB2 | 51676 | RNAseq | 2.6094 | 0.0131 | |
| SRP064894 | ASB2 | 51676 | RNAseq | -0.6720 | 0.0515 | |
| SRP133303 | ASB2 | 51676 | RNAseq | -0.3442 | 0.4925 | |
| SRP159526 | ASB2 | 51676 | RNAseq | -0.9356 | 0.1862 | |
| SRP193095 | ASB2 | 51676 | RNAseq | 0.4852 | 0.0525 | |
| TCGA | ASB2 | 51676 | RNAseq | -0.4195 | 0.0358 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ASB2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ASB2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ASB2 | 51676 | 8 | 4 | 18 | |
| GSE20123 | ASB2 | 51676 | 8 | 3 | 19 | |
| GSE43470 | ASB2 | 51676 | 7 | 3 | 33 | |
| GSE46452 | ASB2 | 51676 | 16 | 3 | 40 | |
| GSE47630 | ASB2 | 51676 | 11 | 8 | 21 | |
| GSE54993 | ASB2 | 51676 | 3 | 8 | 59 | |
| GSE54994 | ASB2 | 51676 | 20 | 4 | 29 | |
| GSE60625 | ASB2 | 51676 | 0 | 2 | 9 | |
| GSE74703 | ASB2 | 51676 | 6 | 3 | 27 | |
| GSE74704 | ASB2 | 51676 | 4 | 3 | 13 | |
| TCGA | ASB2 | 51676 | 29 | 21 | 46 |
Total number of gains: 112; Total number of losses: 62; Total Number of normals: 314.
Somatic mutations of ASB2:
Generating mutation plots.
Highly correlated genes for ASB2:
Showing top 20/389 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ASB2 | RNF139 | 0.761644 | 3 | 0 | 3 |
| ASB2 | SIVA1 | 0.758421 | 3 | 0 | 3 |
| ASB2 | FBN1 | 0.741359 | 3 | 0 | 3 |
| ASB2 | SP100 | 0.740311 | 4 | 0 | 4 |
| ASB2 | NCKIPSD | 0.738018 | 3 | 0 | 3 |
| ASB2 | SLC22A17 | 0.735956 | 3 | 0 | 3 |
| ASB2 | FBLN2 | 0.735672 | 4 | 0 | 4 |
| ASB2 | LMO1 | 0.735066 | 3 | 0 | 3 |
| ASB2 | KLHL21 | 0.73446 | 3 | 0 | 3 |
| ASB2 | COPZ2 | 0.732831 | 3 | 0 | 3 |
| ASB2 | TEAD4 | 0.727783 | 3 | 0 | 3 |
| ASB2 | TTYH2 | 0.722617 | 3 | 0 | 3 |
| ASB2 | EIF5 | 0.717614 | 3 | 0 | 3 |
| ASB2 | PRKCA | 0.716746 | 3 | 0 | 3 |
| ASB2 | USP12 | 0.714935 | 3 | 0 | 3 |
| ASB2 | MYADM | 0.712303 | 3 | 0 | 3 |
| ASB2 | PRKAB2 | 0.709928 | 4 | 0 | 4 |
| ASB2 | POLR2K | 0.705433 | 3 | 0 | 3 |
| ASB2 | RNF220 | 0.699163 | 3 | 0 | 3 |
| ASB2 | CEP112 | 0.699071 | 3 | 0 | 3 |
For details and further investigation, click here
