| Full name: PBX/knotted 1 homeobox 1 | Alias Symbol: PREP1 | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 5316 | HGNC ID: HGNC:9022 | Ensembl Gene: ENSG00000160199 | OMIM ID: 602100 |
| Drug and gene relationship at DGIdb | |||
Expression of PKNOX1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PKNOX1 | 5316 | 204195_s_at | 0.2593 | 0.3120 | |
| GSE20347 | PKNOX1 | 5316 | 221883_at | 0.1534 | 0.0563 | |
| GSE23400 | PKNOX1 | 5316 | 204195_s_at | 0.1301 | 0.0071 | |
| GSE26886 | PKNOX1 | 5316 | 221883_at | 0.5391 | 0.0244 | |
| GSE29001 | PKNOX1 | 5316 | 221883_at | 0.3564 | 0.0442 | |
| GSE38129 | PKNOX1 | 5316 | 204195_s_at | 0.2527 | 0.0072 | |
| GSE45670 | PKNOX1 | 5316 | 221883_at | 0.2733 | 0.1198 | |
| GSE53622 | PKNOX1 | 5316 | 28306 | -0.2478 | 0.0089 | |
| GSE53624 | PKNOX1 | 5316 | 28306 | 0.1206 | 0.0670 | |
| GSE63941 | PKNOX1 | 5316 | 204195_s_at | 0.1744 | 0.4513 | |
| GSE77861 | PKNOX1 | 5316 | 204195_s_at | 0.1745 | 0.2959 | |
| GSE97050 | PKNOX1 | 5316 | A_24_P196534 | -0.1436 | 0.6270 | |
| SRP007169 | PKNOX1 | 5316 | RNAseq | 0.2739 | 0.4570 | |
| SRP008496 | PKNOX1 | 5316 | RNAseq | 0.5216 | 0.0286 | |
| SRP064894 | PKNOX1 | 5316 | RNAseq | 0.6899 | 0.0001 | |
| SRP133303 | PKNOX1 | 5316 | RNAseq | 0.2079 | 0.0770 | |
| SRP159526 | PKNOX1 | 5316 | RNAseq | 0.1793 | 0.3223 | |
| SRP193095 | PKNOX1 | 5316 | RNAseq | 0.4000 | 0.0000 | |
| SRP219564 | PKNOX1 | 5316 | RNAseq | 0.1872 | 0.6195 | |
| TCGA | PKNOX1 | 5316 | RNAseq | 0.0069 | 0.8984 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PKNOX1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PKNOX1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PKNOX1 | 5316 | 2 | 8 | 20 | |
| GSE20123 | PKNOX1 | 5316 | 2 | 8 | 20 | |
| GSE43470 | PKNOX1 | 5316 | 0 | 13 | 30 | |
| GSE46452 | PKNOX1 | 5316 | 1 | 21 | 37 | |
| GSE47630 | PKNOX1 | 5316 | 6 | 17 | 17 | |
| GSE54993 | PKNOX1 | 5316 | 8 | 1 | 61 | |
| GSE54994 | PKNOX1 | 5316 | 4 | 8 | 41 | |
| GSE60625 | PKNOX1 | 5316 | 0 | 0 | 11 | |
| GSE74703 | PKNOX1 | 5316 | 0 | 10 | 26 | |
| GSE74704 | PKNOX1 | 5316 | 1 | 4 | 15 | |
| TCGA | PKNOX1 | 5316 | 7 | 40 | 49 |
Total number of gains: 31; Total number of losses: 130; Total Number of normals: 327.
Somatic mutations of PKNOX1:
Generating mutation plots.
Highly correlated genes for PKNOX1:
Showing top 20/650 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PKNOX1 | RP9 | 0.823819 | 3 | 0 | 3 |
| PKNOX1 | PPP1R16A | 0.766989 | 3 | 0 | 3 |
| PKNOX1 | MED9 | 0.762122 | 3 | 0 | 3 |
| PKNOX1 | KIAA1257 | 0.75204 | 3 | 0 | 3 |
| PKNOX1 | BCL9 | 0.747969 | 3 | 0 | 3 |
| PKNOX1 | DHX36 | 0.739763 | 3 | 0 | 3 |
| PKNOX1 | TEP1 | 0.725692 | 4 | 0 | 4 |
| PKNOX1 | PET117 | 0.723977 | 3 | 0 | 3 |
| PKNOX1 | CCS | 0.719453 | 5 | 0 | 4 |
| PKNOX1 | TRAF2 | 0.718299 | 3 | 0 | 3 |
| PKNOX1 | FTO | 0.716356 | 3 | 0 | 3 |
| PKNOX1 | CRCP | 0.713429 | 4 | 0 | 3 |
| PKNOX1 | SESTD1 | 0.712694 | 3 | 0 | 3 |
| PKNOX1 | MRPS26 | 0.708778 | 3 | 0 | 3 |
| PKNOX1 | ZNF324 | 0.706157 | 3 | 0 | 3 |
| PKNOX1 | INTS3 | 0.701615 | 4 | 0 | 4 |
| PKNOX1 | ACBD6 | 0.701525 | 4 | 0 | 4 |
| PKNOX1 | RBM41 | 0.701463 | 3 | 0 | 3 |
| PKNOX1 | PRR12 | 0.698019 | 3 | 0 | 3 |
| PKNOX1 | TADA2B | 0.697095 | 3 | 0 | 3 |
For details and further investigation, click here
