| Full name: nuclear receptor corepressor 2 | Alias Symbol: SMRT|SMRTE|TRAC-1|CTG26|TNRC14 | ||
| Type: protein-coding gene | Cytoband: 12q24.31 | ||
| Entrez ID: 9612 | HGNC ID: HGNC:7673 | Ensembl Gene: ENSG00000196498 | OMIM ID: 600848 |
| Drug and gene relationship at DGIdb | |||
NCOR2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of NCOR2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NCOR2 | 9612 | 207760_s_at | 0.8547 | 0.0858 | |
| GSE20347 | NCOR2 | 9612 | 207760_s_at | 0.6034 | 0.0000 | |
| GSE23400 | NCOR2 | 9612 | 207760_s_at | 0.5108 | 0.0000 | |
| GSE26886 | NCOR2 | 9612 | 207760_s_at | 1.2298 | 0.0000 | |
| GSE29001 | NCOR2 | 9612 | 207760_s_at | 0.7283 | 0.0141 | |
| GSE38129 | NCOR2 | 9612 | 207760_s_at | 0.5118 | 0.0207 | |
| GSE45670 | NCOR2 | 9612 | 207760_s_at | 0.1703 | 0.2070 | |
| GSE63941 | NCOR2 | 9612 | 207760_s_at | -0.2384 | 0.6224 | |
| GSE77861 | NCOR2 | 9612 | 207760_s_at | 0.7203 | 0.0064 | |
| GSE97050 | NCOR2 | 9612 | A_23_P203891 | 0.0431 | 0.8657 | |
| SRP007169 | NCOR2 | 9612 | RNAseq | 0.6656 | 0.1761 | |
| SRP008496 | NCOR2 | 9612 | RNAseq | 0.8081 | 0.0080 | |
| SRP064894 | NCOR2 | 9612 | RNAseq | 0.2312 | 0.2857 | |
| SRP133303 | NCOR2 | 9612 | RNAseq | 0.3142 | 0.1201 | |
| SRP159526 | NCOR2 | 9612 | RNAseq | 0.7387 | 0.0384 | |
| SRP193095 | NCOR2 | 9612 | RNAseq | 0.6856 | 0.0008 | |
| SRP219564 | NCOR2 | 9612 | RNAseq | 0.2817 | 0.3498 | |
| TCGA | NCOR2 | 9612 | RNAseq | -0.0345 | 0.3804 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NCOR2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of NCOR2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NCOR2 | 9612 | 5 | 5 | 20 | |
| GSE20123 | NCOR2 | 9612 | 5 | 5 | 20 | |
| GSE43470 | NCOR2 | 9612 | 2 | 0 | 41 | |
| GSE46452 | NCOR2 | 9612 | 9 | 1 | 49 | |
| GSE47630 | NCOR2 | 9612 | 9 | 3 | 28 | |
| GSE54993 | NCOR2 | 9612 | 0 | 5 | 65 | |
| GSE54994 | NCOR2 | 9612 | 4 | 8 | 41 | |
| GSE60625 | NCOR2 | 9612 | 0 | 0 | 11 | |
| GSE74703 | NCOR2 | 9612 | 2 | 0 | 34 | |
| GSE74704 | NCOR2 | 9612 | 3 | 3 | 14 | |
| TCGA | NCOR2 | 9612 | 21 | 11 | 64 |
Total number of gains: 60; Total number of losses: 41; Total Number of normals: 387.
Somatic mutations of NCOR2:
Generating mutation plots.
Highly correlated genes for NCOR2:
Showing top 20/1923 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NCOR2 | PKIG | 0.81792 | 4 | 0 | 4 |
| NCOR2 | SSBP4 | 0.794868 | 5 | 0 | 5 |
| NCOR2 | C20orf194 | 0.793455 | 3 | 0 | 3 |
| NCOR2 | BRI3 | 0.789028 | 4 | 0 | 4 |
| NCOR2 | SEC22C | 0.773992 | 3 | 0 | 3 |
| NCOR2 | ZNF518B | 0.773089 | 4 | 0 | 4 |
| NCOR2 | CPT1A | 0.769862 | 3 | 0 | 3 |
| NCOR2 | ZNFX1 | 0.768024 | 3 | 0 | 3 |
| NCOR2 | SLC39A1 | 0.766187 | 5 | 0 | 5 |
| NCOR2 | MIA3 | 0.764688 | 3 | 0 | 3 |
| NCOR2 | PSMG3 | 0.764657 | 3 | 0 | 3 |
| NCOR2 | RAVER1 | 0.756993 | 4 | 0 | 4 |
| NCOR2 | ZNF496 | 0.753219 | 5 | 0 | 4 |
| NCOR2 | EML1 | 0.751738 | 3 | 0 | 3 |
| NCOR2 | ANTXR2 | 0.751497 | 3 | 0 | 3 |
| NCOR2 | PPP1R18 | 0.750371 | 3 | 0 | 3 |
| NCOR2 | SLC39A13 | 0.748963 | 5 | 0 | 4 |
| NCOR2 | ZNF579 | 0.748873 | 3 | 0 | 3 |
| NCOR2 | ANO6 | 0.748787 | 3 | 0 | 3 |
| NCOR2 | SPTAN1 | 0.747033 | 3 | 0 | 3 |
For details and further investigation, click here
