| Full name: interferon regulatory factor 9 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q12 | ||
| Entrez ID: 10379 | HGNC ID: HGNC:6131 | Ensembl Gene: ENSG00000213928 | OMIM ID: 147574 |
| Drug and gene relationship at DGIdb | |||
IRF9 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation | |
| hsa04630 | Jak-STAT signaling pathway | |
| hsa05160 | Hepatitis C | |
| hsa05162 | Measles | |
| hsa05164 | Influenza A | |
| hsa05168 | Herpes simplex infection |
Expression of IRF9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRF9 | 10379 | 203882_at | 0.5767 | 0.4278 | |
| GSE20347 | IRF9 | 10379 | 203882_at | 0.7792 | 0.0014 | |
| GSE23400 | IRF9 | 10379 | 203882_at | 0.7621 | 0.0000 | |
| GSE26886 | IRF9 | 10379 | 203882_at | -0.3103 | 0.4563 | |
| GSE29001 | IRF9 | 10379 | 203882_at | 0.8690 | 0.0022 | |
| GSE38129 | IRF9 | 10379 | 203882_at | 0.6955 | 0.0002 | |
| GSE45670 | IRF9 | 10379 | 203882_at | 1.3089 | 0.0000 | |
| GSE63941 | IRF9 | 10379 | 203882_at | 0.7532 | 0.4186 | |
| GSE77861 | IRF9 | 10379 | 203882_at | 0.8147 | 0.0751 | |
| GSE97050 | IRF9 | 10379 | A_23_P65442 | 0.6319 | 0.1298 | |
| SRP007169 | IRF9 | 10379 | RNAseq | 1.0307 | 0.0190 | |
| SRP008496 | IRF9 | 10379 | RNAseq | 0.5457 | 0.0908 | |
| SRP064894 | IRF9 | 10379 | RNAseq | 1.3857 | 0.0000 | |
| SRP133303 | IRF9 | 10379 | RNAseq | 0.7496 | 0.0104 | |
| SRP159526 | IRF9 | 10379 | RNAseq | -0.3195 | 0.4752 | |
| SRP193095 | IRF9 | 10379 | RNAseq | 0.8564 | 0.0000 | |
| SRP219564 | IRF9 | 10379 | RNAseq | 0.6098 | 0.1720 | |
| TCGA | IRF9 | 10379 | RNAseq | 0.2892 | 0.0001 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by IRF9 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of IRF9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRF9 | 10379 | 8 | 3 | 19 | |
| GSE20123 | IRF9 | 10379 | 8 | 3 | 19 | |
| GSE43470 | IRF9 | 10379 | 8 | 2 | 33 | |
| GSE46452 | IRF9 | 10379 | 16 | 2 | 41 | |
| GSE47630 | IRF9 | 10379 | 11 | 10 | 19 | |
| GSE54993 | IRF9 | 10379 | 3 | 11 | 56 | |
| GSE54994 | IRF9 | 10379 | 18 | 5 | 30 | |
| GSE60625 | IRF9 | 10379 | 0 | 2 | 9 | |
| GSE74703 | IRF9 | 10379 | 7 | 2 | 27 | |
| GSE74704 | IRF9 | 10379 | 3 | 2 | 15 | |
| TCGA | IRF9 | 10379 | 27 | 13 | 56 |
Total number of gains: 109; Total number of losses: 55; Total Number of normals: 324.
Somatic mutations of IRF9:
Generating mutation plots.
Highly correlated genes for IRF9:
Showing top 20/973 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRF9 | CMPK2 | 0.851865 | 3 | 0 | 3 |
| IRF9 | PRICKLE1 | 0.779455 | 3 | 0 | 3 |
| IRF9 | CYP27C1 | 0.775856 | 3 | 0 | 3 |
| IRF9 | CCM2 | 0.76624 | 4 | 0 | 4 |
| IRF9 | XPR1 | 0.764331 | 3 | 0 | 3 |
| IRF9 | IFI6 | 0.759976 | 10 | 0 | 10 |
| IRF9 | PELP1 | 0.758112 | 3 | 0 | 3 |
| IRF9 | SLC39A3 | 0.752986 | 3 | 0 | 3 |
| IRF9 | JKAMP | 0.748372 | 3 | 0 | 3 |
| IRF9 | PARP12 | 0.746997 | 9 | 0 | 8 |
| IRF9 | ACBD6 | 0.736418 | 3 | 0 | 3 |
| IRF9 | WDR54 | 0.728886 | 3 | 0 | 3 |
| IRF9 | PAQR4 | 0.724568 | 3 | 0 | 3 |
| IRF9 | FAM126A | 0.723293 | 3 | 0 | 3 |
| IRF9 | XAF1 | 0.722732 | 8 | 0 | 8 |
| IRF9 | DCAF6 | 0.722384 | 3 | 0 | 3 |
| IRF9 | PRTFDC1 | 0.720031 | 3 | 0 | 3 |
| IRF9 | CRTC2 | 0.719371 | 3 | 0 | 3 |
| IRF9 | ALG2 | 0.71883 | 3 | 0 | 3 |
| IRF9 | CHIC1 | 0.717487 | 3 | 0 | 3 |
For details and further investigation, click here
