CACNA1A

 

Full name: calcium voltage-gated channel subunit alpha1 A Alias Symbol: Cav2.1|EA2|APCA|HPCA|FHM
Type: protein-coding gene Cytoband: 19p13.13
Entrez ID: 773 HGNC ID: HGNC:1388 Ensembl Gene: ENSG00000141837 OMIM ID: 601011
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CACNA1A involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04742Taste transduction
hsa04930Type II diabetes mellitus
hsa05032Morphine addiction

 

Expression of CACNA1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CACNA1A 773 206399_x_at -0.2597 0.2535
GSE20347 CACNA1A 773 206399_x_at -0.3491 0.0008
GSE23400 CACNA1A 773 206399_x_at -0.2241 0.0000
GSE26886 CACNA1A 773 206399_x_at 0.6966 0.0000
GSE29001 CACNA1A 773 214933_at 0.6929 0.1070
GSE38129 CACNA1A 773 206399_x_at -0.2685 0.0012
GSE45670 CACNA1A 773 206399_x_at -0.1636 0.1963
GSE53622 CACNA1A 773 140790 -0.2866 0.0022
GSE53624 CACNA1A 773 140790 -0.1308 0.2182
GSE63941 CACNA1A 773 206399_x_at 0.4688 0.0145
GSE77861 CACNA1A 773 206399_x_at -0.0908 0.6573
GSE97050 CACNA1A 773 A_33_P3275846 0.3360 0.2396
SRP133303 CACNA1A 773 RNAseq 0.0618 0.7802
SRP159526 CACNA1A 773 RNAseq 0.6460 0.3275
SRP219564 CACNA1A 773 RNAseq 0.1630 0.6943
TCGA CACNA1A 773 RNAseq -0.1591 0.5931

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CACNA1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CACNA1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CACNA1A 773 4 2 24
GSE20123 CACNA1A 773 3 1 26
GSE43470 CACNA1A 773 2 6 35
GSE46452 CACNA1A 773 47 1 11
GSE47630 CACNA1A 773 4 7 29
GSE54993 CACNA1A 773 16 3 51
GSE54994 CACNA1A 773 6 13 34
GSE60625 CACNA1A 773 9 0 2
GSE74703 CACNA1A 773 2 4 30
GSE74704 CACNA1A 773 0 1 19
TCGA CACNA1A 773 21 11 64

Total number of gains: 114; Total number of losses: 49; Total Number of normals: 325.  

 

Somatic mutations of CACNA1A:

 

Generating mutation plots.

 

Highly correlated genes for CACNA1A:

 

Showing top 20/516 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CACNA1AVCX20.788495303
CACNA1ARIMS40.773351303
CACNA1ASCUBE10.765897303
CACNA1ASWI50.733299303
CACNA1AHMCN20.728154303
CACNA1ANPBWR10.726227303
CACNA1AGPN20.719268303
CACNA1AARHGAP300.703828404
CACNA1AODF3B0.701222404
CACNA1APEX11G0.700742303
CACNA1APLA2G2F0.697408303
CACNA1AIGSF210.694133303
CACNA1ACCDC1060.69407404
CACNA1AMTUS20.6924404
CACNA1ARCOR20.691057404
CACNA1AVGF0.68971303
CACNA1ASPEF10.686079404
CACNA1AMYO1A0.680967404
CACNA1ALHX10.680579403
CACNA1ARADIL0.679729303

For details and further investigation, click here