| Full name: leucine rich repeats and calponin homology domain containing 1 | Alias Symbol: KIAA1016 | ||
| Type: protein-coding gene | Cytoband: 13q14.13-q14.2 | ||
| Entrez ID: 23143 | HGNC ID: HGNC:20309 | Ensembl Gene: ENSG00000136141 | OMIM ID: 610368 |
| Drug and gene relationship at DGIdb | |||
Expression of LRCH1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRCH1 | 23143 | 226795_at | -0.5368 | 0.3138 | |
| GSE20347 | LRCH1 | 23143 | 214936_at | 0.0543 | 0.5471 | |
| GSE23400 | LRCH1 | 23143 | 214936_at | -0.0832 | 0.0017 | |
| GSE26886 | LRCH1 | 23143 | 226795_at | 0.4853 | 0.0679 | |
| GSE29001 | LRCH1 | 23143 | 214936_at | -0.1715 | 0.3238 | |
| GSE38129 | LRCH1 | 23143 | 214936_at | 0.0063 | 0.9532 | |
| GSE45670 | LRCH1 | 23143 | 226795_at | -0.8215 | 0.0000 | |
| GSE53622 | LRCH1 | 23143 | 375 | -0.1057 | 0.2909 | |
| GSE53624 | LRCH1 | 23143 | 375 | 0.0480 | 0.5261 | |
| GSE63941 | LRCH1 | 23143 | 226795_at | -0.7952 | 0.0488 | |
| GSE77861 | LRCH1 | 23143 | 235012_at | 0.0495 | 0.7418 | |
| GSE97050 | LRCH1 | 23143 | A_33_P3333337 | -0.2954 | 0.5728 | |
| SRP007169 | LRCH1 | 23143 | RNAseq | 1.7016 | 0.0096 | |
| SRP008496 | LRCH1 | 23143 | RNAseq | 2.2610 | 0.0000 | |
| SRP064894 | LRCH1 | 23143 | RNAseq | 0.2623 | 0.3044 | |
| SRP133303 | LRCH1 | 23143 | RNAseq | -0.1785 | 0.3861 | |
| SRP159526 | LRCH1 | 23143 | RNAseq | -0.5677 | 0.0038 | |
| SRP193095 | LRCH1 | 23143 | RNAseq | 0.1021 | 0.6024 | |
| SRP219564 | LRCH1 | 23143 | RNAseq | -0.3798 | 0.4343 | |
| TCGA | LRCH1 | 23143 | RNAseq | -0.2813 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by LRCH1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRCH1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRCH1 | 23143 | 0 | 14 | 16 | |
| GSE20123 | LRCH1 | 23143 | 0 | 13 | 17 | |
| GSE43470 | LRCH1 | 23143 | 3 | 13 | 27 | |
| GSE46452 | LRCH1 | 23143 | 0 | 33 | 26 | |
| GSE47630 | LRCH1 | 23143 | 2 | 27 | 11 | |
| GSE54993 | LRCH1 | 23143 | 12 | 2 | 56 | |
| GSE54994 | LRCH1 | 23143 | 1 | 16 | 36 | |
| GSE60625 | LRCH1 | 23143 | 0 | 3 | 8 | |
| GSE74703 | LRCH1 | 23143 | 3 | 10 | 23 | |
| GSE74704 | LRCH1 | 23143 | 0 | 10 | 10 | |
| TCGA | LRCH1 | 23143 | 8 | 38 | 50 |
Total number of gains: 29; Total number of losses: 179; Total Number of normals: 280.
Somatic mutations of LRCH1:
Generating mutation plots.
Highly correlated genes for LRCH1:
Showing top 20/766 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRCH1 | RGS7BP | 0.810882 | 3 | 0 | 3 |
| LRCH1 | PCDH9 | 0.783759 | 4 | 0 | 4 |
| LRCH1 | MITF | 0.781287 | 4 | 0 | 4 |
| LRCH1 | ROCK1 | 0.763317 | 5 | 0 | 5 |
| LRCH1 | CACNA1C | 0.762009 | 5 | 0 | 5 |
| LRCH1 | PPP1R14A | 0.747622 | 4 | 0 | 4 |
| LRCH1 | TMEM43 | 0.745064 | 3 | 0 | 3 |
| LRCH1 | NCAM1 | 0.742163 | 4 | 0 | 4 |
| LRCH1 | TCEAL3 | 0.725943 | 3 | 0 | 3 |
| LRCH1 | PLP1 | 0.725749 | 4 | 0 | 4 |
| LRCH1 | CNTLN | 0.722272 | 3 | 0 | 3 |
| LRCH1 | CNN1 | 0.719459 | 4 | 0 | 4 |
| LRCH1 | MYADM | 0.712206 | 5 | 0 | 5 |
| LRCH1 | TIMP3 | 0.712198 | 4 | 0 | 3 |
| LRCH1 | OCRL | 0.711705 | 4 | 0 | 4 |
| LRCH1 | KIAA0753 | 0.711203 | 4 | 0 | 4 |
| LRCH1 | SELENBP1 | 0.710122 | 3 | 0 | 3 |
| LRCH1 | CLMP | 0.709179 | 5 | 0 | 5 |
| LRCH1 | AGTR1 | 0.706912 | 5 | 0 | 5 |
| LRCH1 | ZCRB1 | 0.705267 | 3 | 0 | 3 |
For details and further investigation, click here
