| Full name: calcium voltage-gated channel subunit alpha1 D | Alias Symbol: Cav1.3|CACH3|CACN4 | ||
| Type: protein-coding gene | Cytoband: 3p21.1 | ||
| Entrez ID: 776 | HGNC ID: HGNC:1391 | Ensembl Gene: ENSG00000157388 | OMIM ID: 114206 |
| Related drugs: AMLODIPINE, AMLODIPINE BESYLATE, AMLODIPINE MALEATE, ATAGABALIN, AZD1305, AZIDOPINE, BEPRIDIL HYDROCHLORIDE, CHEMBL1082832, CHEMBL93655, CLEVIDIPINE... [more] | |||
CACNA1D involved pathways:
Expression of CACNA1D:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CACNA1D | 776 | 207998_s_at | 0.0517 | 0.8757 | |
| GSE20347 | CACNA1D | 776 | 207998_s_at | 0.0341 | 0.7287 | |
| GSE23400 | CACNA1D | 776 | 207998_s_at | -0.1434 | 0.0001 | |
| GSE26886 | CACNA1D | 776 | 207998_s_at | 0.1658 | 0.1958 | |
| GSE29001 | CACNA1D | 776 | 210108_at | 0.0923 | 0.8381 | |
| GSE38129 | CACNA1D | 776 | 207998_s_at | -0.0880 | 0.2407 | |
| GSE45670 | CACNA1D | 776 | 207998_s_at | 0.0662 | 0.5134 | |
| GSE53622 | CACNA1D | 776 | 129623 | -0.9823 | 0.0000 | |
| GSE53624 | CACNA1D | 776 | 83709 | -1.3816 | 0.0000 | |
| GSE63941 | CACNA1D | 776 | 207998_s_at | 0.1263 | 0.5514 | |
| GSE77861 | CACNA1D | 776 | 207998_s_at | -0.0518 | 0.6073 | |
| GSE97050 | CACNA1D | 776 | A_23_P365767 | -0.3603 | 0.3906 | |
| SRP133303 | CACNA1D | 776 | RNAseq | -1.6562 | 0.0000 | |
| SRP193095 | CACNA1D | 776 | RNAseq | -0.0491 | 0.9042 | |
| SRP219564 | CACNA1D | 776 | RNAseq | -1.9380 | 0.0032 | |
| TCGA | CACNA1D | 776 | RNAseq | -0.9282 | 0.0274 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CACNA1D expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CACNA1D:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CACNA1D | 776 | 0 | 17 | 13 | |
| GSE20123 | CACNA1D | 776 | 0 | 18 | 12 | |
| GSE43470 | CACNA1D | 776 | 0 | 18 | 25 | |
| GSE46452 | CACNA1D | 776 | 2 | 17 | 40 | |
| GSE47630 | CACNA1D | 776 | 1 | 24 | 15 | |
| GSE54993 | CACNA1D | 776 | 6 | 2 | 62 | |
| GSE54994 | CACNA1D | 776 | 0 | 32 | 21 | |
| GSE60625 | CACNA1D | 776 | 5 | 0 | 6 | |
| GSE74703 | CACNA1D | 776 | 0 | 14 | 22 | |
| GSE74704 | CACNA1D | 776 | 0 | 12 | 8 | |
| TCGA | CACNA1D | 776 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 232; Total Number of normals: 242.
Somatic mutations of CACNA1D:
Generating mutation plots.
Highly correlated genes for CACNA1D:
Showing top 20/110 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CACNA1D | LINC00939 | 0.664609 | 4 | 0 | 4 |
| CACNA1D | BMF | 0.654406 | 3 | 0 | 3 |
| CACNA1D | LINC00950 | 0.648454 | 4 | 0 | 4 |
| CACNA1D | LINC01315 | 0.625813 | 3 | 0 | 3 |
| CACNA1D | TRAPPC6A | 0.612693 | 3 | 0 | 3 |
| CACNA1D | SARM1 | 0.611641 | 3 | 0 | 3 |
| CACNA1D | MBD6 | 0.601759 | 3 | 0 | 3 |
| CACNA1D | TMEM232 | 0.600307 | 3 | 0 | 3 |
| CACNA1D | ALX3 | 0.598103 | 4 | 0 | 4 |
| CACNA1D | FXYD7 | 0.595873 | 3 | 0 | 3 |
| CACNA1D | C2orf81 | 0.590415 | 3 | 0 | 3 |
| CACNA1D | GRIN2C | 0.584052 | 4 | 0 | 3 |
| CACNA1D | APOD | 0.579224 | 4 | 0 | 4 |
| CACNA1D | REM1 | 0.579013 | 5 | 0 | 4 |
| CACNA1D | DYRK1B | 0.577458 | 5 | 0 | 3 |
| CACNA1D | KCNK16 | 0.576 | 4 | 0 | 3 |
| CACNA1D | FRMPD1 | 0.57275 | 4 | 0 | 3 |
| CACNA1D | LURAP1 | 0.571868 | 4 | 0 | 4 |
| CACNA1D | RORC | 0.571864 | 4 | 0 | 3 |
| CACNA1D | STX1B | 0.571431 | 3 | 0 | 3 |
For details and further investigation, click here
