| Full name: calcium voltage-gated channel subunit alpha1 S | Alias Symbol: Cav1.1|hypoPP | ||
| Type: protein-coding gene | Cytoband: 1q32.1 | ||
| Entrez ID: 779 | HGNC ID: HGNC:1397 | Ensembl Gene: ENSG00000081248 | OMIM ID: 114208 |
| Drug and gene relationship at DGIdb | |||
CACNA1S involved pathways:
Expression of CACNA1S:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CACNA1S | 779 | 217515_s_at | 0.0275 | 0.9228 | |
| GSE20347 | CACNA1S | 779 | 217515_s_at | 0.0264 | 0.7882 | |
| GSE23400 | CACNA1S | 779 | 217515_s_at | -0.1114 | 0.0000 | |
| GSE26886 | CACNA1S | 779 | 217515_s_at | -0.0310 | 0.8451 | |
| GSE29001 | CACNA1S | 779 | 217515_s_at | -0.1248 | 0.3703 | |
| GSE38129 | CACNA1S | 779 | 217515_s_at | -0.1096 | 0.1550 | |
| GSE45670 | CACNA1S | 779 | 217515_s_at | -0.0162 | 0.9028 | |
| GSE53622 | CACNA1S | 779 | 65554 | 0.2586 | 0.0253 | |
| GSE53624 | CACNA1S | 779 | 65554 | 0.2628 | 0.1613 | |
| GSE63941 | CACNA1S | 779 | 217515_s_at | 0.0331 | 0.8530 | |
| GSE77861 | CACNA1S | 779 | 217515_s_at | 0.0815 | 0.4473 | |
| GSE97050 | CACNA1S | 779 | A_23_P85765 | -0.0579 | 0.8116 | |
| TCGA | CACNA1S | 779 | RNAseq | -0.1862 | 0.8913 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CACNA1S expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CACNA1S:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CACNA1S | 779 | 11 | 0 | 19 | |
| GSE20123 | CACNA1S | 779 | 11 | 0 | 19 | |
| GSE43470 | CACNA1S | 779 | 6 | 0 | 37 | |
| GSE46452 | CACNA1S | 779 | 3 | 1 | 55 | |
| GSE47630 | CACNA1S | 779 | 14 | 0 | 26 | |
| GSE54993 | CACNA1S | 779 | 0 | 6 | 64 | |
| GSE54994 | CACNA1S | 779 | 15 | 0 | 38 | |
| GSE60625 | CACNA1S | 779 | 0 | 0 | 11 | |
| GSE74703 | CACNA1S | 779 | 6 | 0 | 30 | |
| GSE74704 | CACNA1S | 779 | 5 | 0 | 15 | |
| TCGA | CACNA1S | 779 | 43 | 4 | 49 |
Total number of gains: 114; Total number of losses: 11; Total Number of normals: 363.
Somatic mutations of CACNA1S:
Generating mutation plots.
Highly correlated genes for CACNA1S:
Showing top 20/481 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CACNA1S | MIOX | 0.803165 | 3 | 0 | 3 |
| CACNA1S | KCNS1 | 0.743467 | 3 | 0 | 3 |
| CACNA1S | NEUROD4 | 0.739144 | 5 | 0 | 5 |
| CACNA1S | ZNF446 | 0.699916 | 4 | 0 | 4 |
| CACNA1S | MUC3B | 0.689524 | 4 | 0 | 4 |
| CACNA1S | FNDC8 | 0.685029 | 3 | 0 | 3 |
| CACNA1S | NKAIN1 | 0.677434 | 3 | 0 | 3 |
| CACNA1S | NECAB2 | 0.672876 | 3 | 0 | 3 |
| CACNA1S | COLEC10 | 0.667534 | 4 | 0 | 4 |
| CACNA1S | MTNR1B | 0.666218 | 3 | 0 | 3 |
| CACNA1S | SLC17A7 | 0.66085 | 6 | 0 | 5 |
| CACNA1S | RUNX2 | 0.656701 | 4 | 0 | 4 |
| CACNA1S | AMN | 0.656285 | 4 | 0 | 4 |
| CACNA1S | BTNL3 | 0.653826 | 4 | 0 | 4 |
| CACNA1S | KCNQ1DN | 0.653725 | 4 | 0 | 3 |
| CACNA1S | KCNJ11 | 0.647365 | 3 | 0 | 3 |
| CACNA1S | CASC2 | 0.644717 | 3 | 0 | 3 |
| CACNA1S | PRAMEF11 | 0.644303 | 5 | 0 | 4 |
| CACNA1S | THRB | 0.64158 | 3 | 0 | 3 |
| CACNA1S | TOM1L2 | 0.640995 | 3 | 0 | 3 |
For details and further investigation, click here
