| Full name: potassium inwardly rectifying channel subfamily J member 11 | Alias Symbol: Kir6.2|BIR | ||
| Type: protein-coding gene | Cytoband: 11p15.1 | ||
| Entrez ID: 3767 | HGNC ID: HGNC:6257 | Ensembl Gene: ENSG00000187486 | OMIM ID: 600937 |
| Drug and gene relationship at DGIdb | |||
KCNJ11 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04930 | Type II diabetes mellitus |
Expression of KCNJ11:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNJ11 | 3767 | 231740_at | 0.0132 | 0.9676 | |
| GSE26886 | KCNJ11 | 3767 | 231740_at | 0.1747 | 0.0914 | |
| GSE45670 | KCNJ11 | 3767 | 231740_at | 0.0827 | 0.3566 | |
| GSE53622 | KCNJ11 | 3767 | 45294 | -0.1054 | 0.1981 | |
| GSE53624 | KCNJ11 | 3767 | 45294 | 0.0222 | 0.8653 | |
| GSE63941 | KCNJ11 | 3767 | 231740_at | 0.3307 | 0.1097 | |
| GSE77861 | KCNJ11 | 3767 | 231740_at | 0.0174 | 0.9136 | |
| GSE97050 | KCNJ11 | 3767 | A_23_P1973 | 0.0457 | 0.8643 | |
| SRP133303 | KCNJ11 | 3767 | RNAseq | -0.0686 | 0.8055 | |
| SRP159526 | KCNJ11 | 3767 | RNAseq | 1.0854 | 0.1208 | |
| SRP193095 | KCNJ11 | 3767 | RNAseq | -0.0849 | 0.7102 | |
| SRP219564 | KCNJ11 | 3767 | RNAseq | -0.7353 | 0.2336 | |
| TCGA | KCNJ11 | 3767 | RNAseq | -1.6205 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KCNJ11 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNJ11:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNJ11 | 3767 | 0 | 10 | 20 | |
| GSE20123 | KCNJ11 | 3767 | 0 | 10 | 20 | |
| GSE43470 | KCNJ11 | 3767 | 1 | 5 | 37 | |
| GSE46452 | KCNJ11 | 3767 | 7 | 5 | 47 | |
| GSE47630 | KCNJ11 | 3767 | 3 | 10 | 27 | |
| GSE54993 | KCNJ11 | 3767 | 3 | 0 | 67 | |
| GSE54994 | KCNJ11 | 3767 | 3 | 12 | 38 | |
| GSE60625 | KCNJ11 | 3767 | 0 | 0 | 11 | |
| GSE74703 | KCNJ11 | 3767 | 1 | 3 | 32 | |
| GSE74704 | KCNJ11 | 3767 | 0 | 9 | 11 | |
| TCGA | KCNJ11 | 3767 | 11 | 29 | 56 |
Total number of gains: 29; Total number of losses: 93; Total Number of normals: 366.
Somatic mutations of KCNJ11:
Generating mutation plots.
Highly correlated genes for KCNJ11:
Showing top 20/97 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNJ11 | SLC6A3 | 0.740843 | 3 | 0 | 3 |
| KCNJ11 | GPR182 | 0.72978 | 3 | 0 | 3 |
| KCNJ11 | RNF215 | 0.708777 | 3 | 0 | 3 |
| KCNJ11 | ST8SIA3 | 0.704638 | 3 | 0 | 3 |
| KCNJ11 | SLC22A9 | 0.692992 | 3 | 0 | 3 |
| KCNJ11 | TEKT2 | 0.690855 | 3 | 0 | 3 |
| KCNJ11 | HCRTR1 | 0.685608 | 3 | 0 | 3 |
| KCNJ11 | MYL7 | 0.681904 | 4 | 0 | 4 |
| KCNJ11 | ATCAY | 0.67483 | 3 | 0 | 3 |
| KCNJ11 | STK16 | 0.665807 | 3 | 0 | 3 |
| KCNJ11 | GREB1 | 0.661641 | 3 | 0 | 3 |
| KCNJ11 | KIF26A | 0.659775 | 3 | 0 | 3 |
| KCNJ11 | NMUR1 | 0.655097 | 3 | 0 | 3 |
| KCNJ11 | CACNA1S | 0.647365 | 3 | 0 | 3 |
| KCNJ11 | ABCC6 | 0.646625 | 3 | 0 | 3 |
| KCNJ11 | ACR | 0.645642 | 4 | 0 | 4 |
| KCNJ11 | LACRT | 0.644975 | 3 | 0 | 3 |
| KCNJ11 | SP8 | 0.64165 | 3 | 0 | 3 |
| KCNJ11 | PSPN | 0.637643 | 3 | 0 | 3 |
| KCNJ11 | GRIK4 | 0.632513 | 4 | 0 | 3 |
For details and further investigation, click here
