| Full name: zinc finger protein 446 | Alias Symbol: ZKSCAN20|FLJ20626|ZSCAN52 | ||
| Type: protein-coding gene | Cytoband: 19q13.43 | ||
| Entrez ID: 55663 | HGNC ID: HGNC:21036 | Ensembl Gene: ENSG00000083838 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of ZNF446:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ZNF446 | 55663 | 219900_s_at | 0.0322 | 0.9128 | |
| GSE20347 | ZNF446 | 55663 | 219900_s_at | 0.0364 | 0.6566 | |
| GSE23400 | ZNF446 | 55663 | 219900_s_at | -0.0347 | 0.3766 | |
| GSE26886 | ZNF446 | 55663 | 219900_s_at | 0.7689 | 0.0000 | |
| GSE29001 | ZNF446 | 55663 | 219900_s_at | -0.0842 | 0.6404 | |
| GSE38129 | ZNF446 | 55663 | 219900_s_at | 0.0353 | 0.7148 | |
| GSE45670 | ZNF446 | 55663 | 219900_s_at | 0.0432 | 0.6368 | |
| GSE53622 | ZNF446 | 55663 | 81771 | 0.0688 | 0.1675 | |
| GSE53624 | ZNF446 | 55663 | 81771 | 0.1265 | 0.0344 | |
| GSE63941 | ZNF446 | 55663 | 219900_s_at | -0.1628 | 0.4556 | |
| GSE77861 | ZNF446 | 55663 | 1554160_a_at | 0.0696 | 0.6270 | |
| GSE97050 | ZNF446 | 55663 | A_33_P3263756 | -0.0818 | 0.6941 | |
| SRP007169 | ZNF446 | 55663 | RNAseq | -1.0276 | 0.0360 | |
| SRP008496 | ZNF446 | 55663 | RNAseq | -0.5084 | 0.2055 | |
| SRP064894 | ZNF446 | 55663 | RNAseq | 0.5697 | 0.0234 | |
| SRP133303 | ZNF446 | 55663 | RNAseq | -0.1106 | 0.3839 | |
| SRP159526 | ZNF446 | 55663 | RNAseq | 0.1517 | 0.5578 | |
| SRP193095 | ZNF446 | 55663 | RNAseq | 0.3349 | 0.0023 | |
| SRP219564 | ZNF446 | 55663 | RNAseq | 0.1556 | 0.6445 | |
| TCGA | ZNF446 | 55663 | RNAseq | 0.0265 | 0.7495 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by ZNF446 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ZNF446:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ZNF446 | 55663 | 2 | 5 | 23 | |
| GSE20123 | ZNF446 | 55663 | 2 | 4 | 24 | |
| GSE43470 | ZNF446 | 55663 | 3 | 9 | 31 | |
| GSE46452 | ZNF446 | 55663 | 45 | 1 | 13 | |
| GSE47630 | ZNF446 | 55663 | 7 | 6 | 27 | |
| GSE54993 | ZNF446 | 55663 | 18 | 4 | 48 | |
| GSE54994 | ZNF446 | 55663 | 5 | 12 | 36 | |
| GSE60625 | ZNF446 | 55663 | 9 | 0 | 2 | |
| GSE74703 | ZNF446 | 55663 | 3 | 6 | 27 | |
| GSE74704 | ZNF446 | 55663 | 2 | 1 | 17 | |
| TCGA | ZNF446 | 55663 | 20 | 19 | 57 |
Total number of gains: 116; Total number of losses: 67; Total Number of normals: 305.
Somatic mutations of ZNF446:
Generating mutation plots.
Highly correlated genes for ZNF446:
Showing top 20/652 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ZNF446 | GTF2IRD2 | 0.825461 | 3 | 0 | 3 |
| ZNF446 | STAC3 | 0.80458 | 3 | 0 | 3 |
| ZNF446 | C19orf25 | 0.767793 | 3 | 0 | 3 |
| ZNF446 | FERD3L | 0.76598 | 3 | 0 | 3 |
| ZNF446 | CPAMD8 | 0.759015 | 3 | 0 | 3 |
| ZNF446 | OBSL1 | 0.756695 | 3 | 0 | 3 |
| ZNF446 | COL24A1 | 0.747834 | 3 | 0 | 3 |
| ZNF446 | TMEM102 | 0.747671 | 3 | 0 | 3 |
| ZNF446 | TOR2A | 0.745147 | 3 | 0 | 3 |
| ZNF446 | AMPD2 | 0.74326 | 4 | 0 | 4 |
| ZNF446 | RAB3IL1 | 0.731773 | 4 | 0 | 4 |
| ZNF446 | IER5L | 0.730946 | 3 | 0 | 3 |
| ZNF446 | SLC27A5 | 0.73063 | 3 | 0 | 3 |
| ZNF446 | SCUBE1 | 0.72907 | 3 | 0 | 3 |
| ZNF446 | SPATA2L | 0.723636 | 4 | 0 | 3 |
| ZNF446 | ZNF777 | 0.718955 | 4 | 0 | 3 |
| ZNF446 | MGAT5B | 0.710392 | 3 | 0 | 3 |
| ZNF446 | COPS7B | 0.708217 | 4 | 0 | 4 |
| ZNF446 | PVALB | 0.705553 | 3 | 0 | 3 |
| ZNF446 | HAUS5 | 0.703888 | 5 | 0 | 5 |
For details and further investigation, click here
