CAMK4

 

Full name: calcium/calmodulin dependent protein kinase IV Alias Symbol: CaMK-GR|CaMKIV
Type: protein-coding gene Cytoband: 5q22.1
Entrez ID: 814 HGNC ID: HGNC:1464 Ensembl Gene: ENSG00000152495 OMIM ID: 114080
Drug and gene relationship at DGIdb

 

CAMK4 involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04024cAMP signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04380Osteoclast differentiation
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04725Cholinergic synapse
hsa04921Oxytocin signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa05031Amphetamine addiction
hsa05034Alcoholism

 

Expression of CAMK4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CAMK4 814 229029_at 0.3941 0.6044
GSE20347 CAMK4 814 210349_at -0.0481 0.4729
GSE23400 CAMK4 814 210349_at -0.1159 0.0008
GSE26886 CAMK4 814 229029_at 0.1062 0.5986
GSE29001 CAMK4 814 210349_at -0.0932 0.4003
GSE38129 CAMK4 814 210349_at -0.0628 0.2421
GSE45670 CAMK4 814 229029_at 0.2012 0.4865
GSE53622 CAMK4 814 119847 -0.0760 0.5653
GSE53624 CAMK4 814 119847 0.1851 0.1369
GSE63941 CAMK4 814 241871_at -1.4755 0.0589
GSE77861 CAMK4 814 229029_at 0.1188 0.4055
GSE97050 CAMK4 814 A_23_P250347 0.1971 0.5281
SRP007169 CAMK4 814 RNAseq 0.9253 0.2449
SRP008496 CAMK4 814 RNAseq 0.7429 0.1617
SRP064894 CAMK4 814 RNAseq -0.1562 0.5308
SRP133303 CAMK4 814 RNAseq 0.3160 0.2832
SRP159526 CAMK4 814 RNAseq -0.1337 0.8302
SRP193095 CAMK4 814 RNAseq -0.0928 0.6241
SRP219564 CAMK4 814 RNAseq -0.1704 0.7795
TCGA CAMK4 814 RNAseq 0.4020 0.1756

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CAMK4 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CAMK4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CAMK4 814 1 13 16
GSE20123 CAMK4 814 1 13 16
GSE43470 CAMK4 814 3 8 32
GSE46452 CAMK4 814 0 28 31
GSE47630 CAMK4 814 0 21 19
GSE54993 CAMK4 814 9 1 60
GSE54994 CAMK4 814 1 17 35
GSE60625 CAMK4 814 0 0 11
GSE74703 CAMK4 814 2 6 28
GSE74704 CAMK4 814 1 7 12
TCGA CAMK4 814 2 42 52

Total number of gains: 20; Total number of losses: 156; Total Number of normals: 312.  

 

Somatic mutations of CAMK4:

 

Generating mutation plots.

 

Highly correlated genes for CAMK4:

 

Showing top 20/257 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CAMK4TAAR20.776203303
CAMK4FAM153A0.725454303
CAMK4PRAMEF120.721955303
CAMK4TRABD2A0.701147303
CAMK4RFPL20.695873303
CAMK4LMAN10.693349303
CAMK4IL9R0.682495403
CAMK4MSH40.681956303
CAMK4IL2RA0.678588404
CAMK4RLBP10.677404303
CAMK4PSG70.672151303
CAMK4SI0.669143303
CAMK4KLRD10.663551505
CAMK4GRIN2B0.66319403
CAMK4VENTX0.658564303
CAMK4CGA0.658234403
CAMK4SERPIND10.656689303
CAMK4NEUROD10.647843403
CAMK4KIR2DS20.646437404
CAMK4RAB3B0.645821303

For details and further investigation, click here