| Full name: caspase 10 | Alias Symbol: MCH4 | ||
| Type: protein-coding gene | Cytoband: 2q33.1 | ||
| Entrez ID: 843 | HGNC ID: HGNC:1500 | Ensembl Gene: ENSG00000003400 | OMIM ID: 601762 |
| Drug and gene relationship at DGIdb | |||
CASP10 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis | |
| hsa04622 | RIG-I-like receptor signaling pathway | |
| hsa04668 | TNF signaling pathway | |
| hsa05152 | Tuberculosis | |
| hsa05161 | Hepatitis B |
Expression of CASP10:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CASP10 | 843 | 210708_x_at | -0.1791 | 0.5411 | |
| GSE20347 | CASP10 | 843 | 210955_at | -0.1555 | 0.1505 | |
| GSE23400 | CASP10 | 843 | 210708_x_at | -0.2491 | 0.0000 | |
| GSE26886 | CASP10 | 843 | 205467_at | -1.5186 | 0.0000 | |
| GSE29001 | CASP10 | 843 | 205467_at | -0.6278 | 0.0158 | |
| GSE38129 | CASP10 | 843 | 205467_at | -0.3884 | 0.0008 | |
| GSE45670 | CASP10 | 843 | 205467_at | 0.2503 | 0.3631 | |
| GSE53622 | CASP10 | 843 | 152815 | -0.4696 | 0.0000 | |
| GSE53624 | CASP10 | 843 | 152815 | -0.7849 | 0.0000 | |
| GSE63941 | CASP10 | 843 | 205467_at | 0.6137 | 0.3221 | |
| GSE77861 | CASP10 | 843 | 210955_at | -0.2307 | 0.0450 | |
| GSE97050 | CASP10 | 843 | A_33_P3383283 | -0.0354 | 0.9029 | |
| SRP007169 | CASP10 | 843 | RNAseq | -2.2361 | 0.0000 | |
| SRP008496 | CASP10 | 843 | RNAseq | -2.3081 | 0.0000 | |
| SRP064894 | CASP10 | 843 | RNAseq | -0.5735 | 0.0062 | |
| SRP133303 | CASP10 | 843 | RNAseq | -0.5419 | 0.0004 | |
| SRP159526 | CASP10 | 843 | RNAseq | -1.3123 | 0.0006 | |
| SRP193095 | CASP10 | 843 | RNAseq | -1.0090 | 0.0000 | |
| SRP219564 | CASP10 | 843 | RNAseq | -0.3433 | 0.4025 | |
| TCGA | CASP10 | 843 | RNAseq | -0.2212 | 0.0558 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by CASP10 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CASP10:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CASP10 | 843 | 6 | 4 | 20 | |
| GSE20123 | CASP10 | 843 | 6 | 4 | 20 | |
| GSE43470 | CASP10 | 843 | 1 | 1 | 41 | |
| GSE46452 | CASP10 | 843 | 1 | 4 | 54 | |
| GSE47630 | CASP10 | 843 | 4 | 5 | 31 | |
| GSE54993 | CASP10 | 843 | 0 | 3 | 67 | |
| GSE54994 | CASP10 | 843 | 10 | 8 | 35 | |
| GSE60625 | CASP10 | 843 | 0 | 3 | 8 | |
| GSE74703 | CASP10 | 843 | 1 | 1 | 34 | |
| GSE74704 | CASP10 | 843 | 3 | 2 | 15 | |
| TCGA | CASP10 | 843 | 22 | 10 | 64 |
Total number of gains: 54; Total number of losses: 45; Total Number of normals: 389.
Somatic mutations of CASP10:
Generating mutation plots.
Highly correlated genes for CASP10:
Showing top 20/965 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CASP10 | ZNF416 | 0.735047 | 3 | 0 | 3 |
| CASP10 | RBM20 | 0.734708 | 3 | 0 | 3 |
| CASP10 | KIAA0355 | 0.720094 | 3 | 0 | 3 |
| CASP10 | ATP6V0D1 | 0.710673 | 3 | 0 | 3 |
| CASP10 | NDUFA13 | 0.705373 | 3 | 0 | 3 |
| CASP10 | ZCCHC9 | 0.703622 | 3 | 0 | 3 |
| CASP10 | CSDE1 | 0.698965 | 4 | 0 | 3 |
| CASP10 | RAD23B | 0.697585 | 3 | 0 | 3 |
| CASP10 | VSIG2 | 0.696268 | 4 | 0 | 4 |
| CASP10 | CAPN7 | 0.695935 | 3 | 0 | 3 |
| CASP10 | MAML2 | 0.692077 | 3 | 0 | 3 |
| CASP10 | FAM3D | 0.690383 | 4 | 0 | 4 |
| CASP10 | CHN2 | 0.689182 | 3 | 0 | 3 |
| CASP10 | IKZF5 | 0.679668 | 3 | 0 | 3 |
| CASP10 | FAM47A | 0.677597 | 4 | 0 | 3 |
| CASP10 | RDH12 | 0.676881 | 3 | 0 | 3 |
| CASP10 | NGLY1 | 0.673134 | 5 | 0 | 4 |
| CASP10 | ZDHHC5 | 0.6722 | 4 | 0 | 3 |
| CASP10 | TIFA | 0.671017 | 3 | 0 | 3 |
| CASP10 | STXBP5 | 0.670344 | 4 | 0 | 3 |
For details and further investigation, click here
