CSDE1

 

Full name: cold shock domain containing E1 Alias Symbol: D1S155E|UNR
Type: protein-coding gene Cytoband: 1p13.2
Entrez ID: 7812 HGNC ID: HGNC:29905 Ensembl Gene: ENSG00000009307 OMIM ID: 191510
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 30/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of CSDE1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CSDE1 7812 219939_s_at -0.4795 0.2706
GSE20347 CSDE1 7812 219939_s_at -0.6406 0.0004
GSE23400 CSDE1 7812 202646_s_at -0.2732 0.0037
GSE26886 CSDE1 7812 222975_s_at -1.6414 0.0000
GSE29001 CSDE1 7812 202646_s_at -0.0805 0.8266
GSE38129 CSDE1 7812 219939_s_at -0.6950 0.0000
GSE45670 CSDE1 7812 219939_s_at -0.5872 0.0000
GSE53622 CSDE1 7812 2349 -0.8844 0.0000
GSE53624 CSDE1 7812 2349 -0.5284 0.0000
GSE63941 CSDE1 7812 219939_s_at -0.6103 0.1868
GSE77861 CSDE1 7812 219939_s_at -0.6219 0.0101
GSE97050 CSDE1 7812 A_32_P73821 -0.5835 0.1110
SRP007169 CSDE1 7812 RNAseq -0.0893 0.8056
SRP008496 CSDE1 7812 RNAseq -0.1822 0.3892
SRP064894 CSDE1 7812 RNAseq -0.3132 0.0130
SRP133303 CSDE1 7812 RNAseq -0.1864 0.2641
SRP159526 CSDE1 7812 RNAseq -0.6312 0.0009
SRP193095 CSDE1 7812 RNAseq -0.5215 0.0000
SRP219564 CSDE1 7812 RNAseq -0.8065 0.1483
TCGA CSDE1 7812 RNAseq -0.1395 0.0003

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by CSDE1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CSDE1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CSDE1 7812 0 9 21
GSE20123 CSDE1 7812 0 9 21
GSE43470 CSDE1 7812 0 8 35
GSE46452 CSDE1 7812 2 1 56
GSE47630 CSDE1 7812 9 5 26
GSE54993 CSDE1 7812 0 1 69
GSE54994 CSDE1 7812 7 3 43
GSE60625 CSDE1 7812 0 0 11
GSE74703 CSDE1 7812 0 7 29
GSE74704 CSDE1 7812 0 5 15
TCGA CSDE1 7812 13 30 53

Total number of gains: 31; Total number of losses: 78; Total Number of normals: 379.  

 

Somatic mutations of CSDE1:

 

Generating mutation plots.

 

Highly correlated genes for CSDE1:

 

Showing top 20/1323 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CSDE1PREX20.822058303
CSDE1CYP4V20.790187303
CSDE1AKAP60.787419303
CSDE1SLMAP0.769732706
CSDE1EIF4E30.755336706
CSDE1BLOC1S20.750513303
CSDE1TMEM2340.750286303
CSDE1MRPL390.748988505
CSDE1ANAPC160.747319504
CSDE1HIPK10.7467691009
CSDE1CLEC3B0.74638303
CSDE1RPP300.744246303
CSDE1MTFR1L0.741288505
CSDE1TMEM2180.740892303
CSDE1SEC24C0.740095303
CSDE1PDK30.737495403
CSDE1OIP5-AS10.735873303
CSDE1BDH20.735526606
CSDE1MACROD20.735455303
CSDE1FAM83D0.733407404

For details and further investigation, click here