| Full name: chimerin 2 | Alias Symbol: ARHGAP3|RhoGAP3 | ||
| Type: protein-coding gene | Cytoband: 7p14.3 | ||
| Entrez ID: 1124 | HGNC ID: HGNC:1944 | Ensembl Gene: ENSG00000106069 | OMIM ID: 602857 |
| Drug and gene relationship at DGIdb | |||
Expression of CHN2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CHN2 | 1124 | 207486_x_at | -0.2376 | 0.3083 | |
| GSE20347 | CHN2 | 1124 | 207486_x_at | -0.0824 | 0.3344 | |
| GSE23400 | CHN2 | 1124 | 207486_x_at | -0.0716 | 0.0079 | |
| GSE26886 | CHN2 | 1124 | 207486_x_at | -0.0161 | 0.8919 | |
| GSE29001 | CHN2 | 1124 | 213385_at | 0.0372 | 0.9165 | |
| GSE38129 | CHN2 | 1124 | 213385_at | -0.2291 | 0.4482 | |
| GSE45670 | CHN2 | 1124 | 207486_x_at | -0.0917 | 0.2324 | |
| GSE53622 | CHN2 | 1124 | 42510 | -0.3334 | 0.0197 | |
| GSE53624 | CHN2 | 1124 | 42510 | -0.3535 | 0.0065 | |
| GSE63941 | CHN2 | 1124 | 207486_x_at | 0.1018 | 0.7314 | |
| GSE77861 | CHN2 | 1124 | 207486_x_at | -0.1270 | 0.0999 | |
| GSE97050 | CHN2 | 1124 | A_33_P3237899 | -0.0059 | 0.9877 | |
| SRP064894 | CHN2 | 1124 | RNAseq | 0.1898 | 0.5715 | |
| SRP133303 | CHN2 | 1124 | RNAseq | 0.0836 | 0.7393 | |
| SRP159526 | CHN2 | 1124 | RNAseq | 0.4619 | 0.2983 | |
| SRP193095 | CHN2 | 1124 | RNAseq | -0.6358 | 0.1447 | |
| SRP219564 | CHN2 | 1124 | RNAseq | 0.1520 | 0.7583 | |
| TCGA | CHN2 | 1124 | RNAseq | -0.7871 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CHN2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CHN2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CHN2 | 1124 | 16 | 0 | 14 | |
| GSE20123 | CHN2 | 1124 | 16 | 0 | 14 | |
| GSE43470 | CHN2 | 1124 | 4 | 0 | 39 | |
| GSE46452 | CHN2 | 1124 | 11 | 1 | 47 | |
| GSE47630 | CHN2 | 1124 | 8 | 1 | 31 | |
| GSE54993 | CHN2 | 1124 | 0 | 6 | 64 | |
| GSE54994 | CHN2 | 1124 | 19 | 3 | 31 | |
| GSE60625 | CHN2 | 1124 | 0 | 0 | 11 | |
| GSE74703 | CHN2 | 1124 | 4 | 0 | 32 | |
| GSE74704 | CHN2 | 1124 | 10 | 0 | 10 | |
| TCGA | CHN2 | 1124 | 55 | 6 | 35 |
Total number of gains: 143; Total number of losses: 17; Total Number of normals: 328.
Somatic mutations of CHN2:
Generating mutation plots.
Highly correlated genes for CHN2:
Showing top 20/547 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CHN2 | ID4 | 0.766096 | 3 | 0 | 3 |
| CHN2 | GNG2 | 0.752255 | 3 | 0 | 3 |
| CHN2 | BBS1 | 0.749239 | 3 | 0 | 3 |
| CHN2 | STXBP5 | 0.748299 | 3 | 0 | 3 |
| CHN2 | SPOP | 0.730299 | 3 | 0 | 3 |
| CHN2 | TPP1 | 0.720601 | 3 | 0 | 3 |
| CHN2 | DAPK1 | 0.718071 | 3 | 0 | 3 |
| CHN2 | GSTK1 | 0.717165 | 3 | 0 | 3 |
| CHN2 | KCTD12 | 0.715768 | 5 | 0 | 4 |
| CHN2 | FBLN5 | 0.710052 | 5 | 0 | 5 |
| CHN2 | GNG3 | 0.706446 | 3 | 0 | 3 |
| CHN2 | MAN2B2 | 0.70481 | 3 | 0 | 3 |
| CHN2 | ZNF25 | 0.703608 | 3 | 0 | 3 |
| CHN2 | AK3 | 0.70353 | 3 | 0 | 3 |
| CHN2 | GULP1 | 0.702568 | 3 | 0 | 3 |
| CHN2 | ZNF844 | 0.702175 | 4 | 0 | 3 |
| CHN2 | INO80D | 0.698226 | 3 | 0 | 3 |
| CHN2 | OSBPL10 | 0.694967 | 3 | 0 | 3 |
| CHN2 | TMEM80 | 0.693035 | 3 | 0 | 3 |
| CHN2 | LILRB5 | 0.691481 | 5 | 0 | 4 |
For details and further investigation, click here
