| Full name: mastermind like transcriptional coactivator 2 | Alias Symbol: KIAA1819|MAM3 | ||
| Type: protein-coding gene | Cytoband: 11q21 | ||
| Entrez ID: 84441 | HGNC ID: HGNC:16259 | Ensembl Gene: ENSG00000184384 | OMIM ID: 607537 |
| Drug and gene relationship at DGIdb | |||
MAML2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of MAML2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAML2 | 84441 | 235457_at | -1.0492 | 0.0226 | |
| GSE26886 | MAML2 | 84441 | 235457_at | 0.3896 | 0.4151 | |
| GSE45670 | MAML2 | 84441 | 235457_at | -1.1152 | 0.0000 | |
| GSE53622 | MAML2 | 84441 | 45160 | -0.2688 | 0.0092 | |
| GSE53624 | MAML2 | 84441 | 45160 | -0.4451 | 0.0000 | |
| GSE63941 | MAML2 | 84441 | 235457_at | -2.3964 | 0.0185 | |
| GSE77861 | MAML2 | 84441 | 235106_at | -0.1961 | 0.0469 | |
| GSE97050 | MAML2 | 84441 | A_24_P169092 | 0.0318 | 0.9443 | |
| SRP007169 | MAML2 | 84441 | RNAseq | -0.2460 | 0.5381 | |
| SRP008496 | MAML2 | 84441 | RNAseq | 0.2169 | 0.4482 | |
| SRP064894 | MAML2 | 84441 | RNAseq | -0.2574 | 0.4112 | |
| SRP133303 | MAML2 | 84441 | RNAseq | -0.6395 | 0.0008 | |
| SRP159526 | MAML2 | 84441 | RNAseq | 0.0529 | 0.8951 | |
| SRP193095 | MAML2 | 84441 | RNAseq | 0.0379 | 0.8490 | |
| SRP219564 | MAML2 | 84441 | RNAseq | -0.4709 | 0.3243 | |
| TCGA | MAML2 | 84441 | RNAseq | -0.0878 | 0.3887 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by MAML2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAML2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAML2 | 84441 | 3 | 9 | 18 | |
| GSE20123 | MAML2 | 84441 | 3 | 9 | 18 | |
| GSE43470 | MAML2 | 84441 | 2 | 5 | 36 | |
| GSE46452 | MAML2 | 84441 | 5 | 24 | 30 | |
| GSE47630 | MAML2 | 84441 | 2 | 19 | 19 | |
| GSE54993 | MAML2 | 84441 | 9 | 2 | 59 | |
| GSE54994 | MAML2 | 84441 | 6 | 18 | 29 | |
| GSE60625 | MAML2 | 84441 | 0 | 3 | 8 | |
| GSE74703 | MAML2 | 84441 | 1 | 4 | 31 | |
| GSE74704 | MAML2 | 84441 | 3 | 5 | 12 | |
| TCGA | MAML2 | 84441 | 12 | 42 | 42 |
Total number of gains: 46; Total number of losses: 140; Total Number of normals: 302.
Somatic mutations of MAML2:
Generating mutation plots.
Highly correlated genes for MAML2:
Showing top 20/513 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAML2 | CPPED1 | 0.764777 | 4 | 0 | 4 |
| MAML2 | CHMP2A | 0.74458 | 3 | 0 | 3 |
| MAML2 | PRPH2 | 0.743723 | 4 | 0 | 4 |
| MAML2 | APIP | 0.731508 | 3 | 0 | 3 |
| MAML2 | SMDT1 | 0.728 | 3 | 0 | 3 |
| MAML2 | TFPI | 0.724381 | 3 | 0 | 3 |
| MAML2 | YAP1 | 0.717043 | 4 | 0 | 3 |
| MAML2 | CLDN5 | 0.716989 | 3 | 0 | 3 |
| MAML2 | DHDDS | 0.712989 | 4 | 0 | 4 |
| MAML2 | CRYL1 | 0.712686 | 4 | 0 | 4 |
| MAML2 | FAM114A2 | 0.711643 | 3 | 0 | 3 |
| MAML2 | WDR27 | 0.711016 | 3 | 0 | 3 |
| MAML2 | LMAN2 | 0.707703 | 3 | 0 | 3 |
| MAML2 | KLF4 | 0.707449 | 3 | 0 | 3 |
| MAML2 | ATXN10 | 0.703753 | 3 | 0 | 3 |
| MAML2 | EPB41L3 | 0.702857 | 4 | 0 | 3 |
| MAML2 | PDLIM2 | 0.699927 | 5 | 0 | 5 |
| MAML2 | TRIM6 | 0.69884 | 3 | 0 | 3 |
| MAML2 | SLC6A1 | 0.698418 | 3 | 0 | 3 |
| MAML2 | SNX3 | 0.69715 | 4 | 0 | 4 |
For details and further investigation, click here
