| Full name: carbonyl reductase 3 | Alias Symbol: SDR21C2 | ||
| Type: protein-coding gene | Cytoband: 21q22.12 | ||
| Entrez ID: 874 | HGNC ID: HGNC:1549 | Ensembl Gene: ENSG00000159231 | OMIM ID: 603608 |
| Drug and gene relationship at DGIdb | |||
Expression of CBR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBR3 | 874 | 205379_at | -1.1480 | 0.0179 | |
| GSE20347 | CBR3 | 874 | 205379_at | -1.0941 | 0.0001 | |
| GSE23400 | CBR3 | 874 | 205379_at | -0.7569 | 0.0000 | |
| GSE26886 | CBR3 | 874 | 205379_at | -1.3347 | 0.0023 | |
| GSE29001 | CBR3 | 874 | 205379_at | -1.1541 | 0.0456 | |
| GSE38129 | CBR3 | 874 | 205379_at | -0.7291 | 0.0177 | |
| GSE45670 | CBR3 | 874 | 205379_at | -0.2094 | 0.5165 | |
| GSE53622 | CBR3 | 874 | 104686 | -1.3222 | 0.0000 | |
| GSE53624 | CBR3 | 874 | 104686 | -1.3031 | 0.0000 | |
| GSE63941 | CBR3 | 874 | 205379_at | -0.3013 | 0.7879 | |
| GSE77861 | CBR3 | 874 | 205379_at | -0.5318 | 0.3088 | |
| GSE97050 | CBR3 | 874 | A_23_P40453 | -0.3088 | 0.2798 | |
| SRP007169 | CBR3 | 874 | RNAseq | -2.0802 | 0.0000 | |
| SRP008496 | CBR3 | 874 | RNAseq | -1.7805 | 0.0000 | |
| SRP064894 | CBR3 | 874 | RNAseq | -1.1006 | 0.0009 | |
| SRP133303 | CBR3 | 874 | RNAseq | -1.8071 | 0.0000 | |
| SRP159526 | CBR3 | 874 | RNAseq | -0.5303 | 0.3782 | |
| SRP193095 | CBR3 | 874 | RNAseq | -1.1307 | 0.0025 | |
| SRP219564 | CBR3 | 874 | RNAseq | -1.8116 | 0.0016 | |
| TCGA | CBR3 | 874 | RNAseq | 0.6192 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by CBR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CBR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBR3 | 874 | 2 | 8 | 20 | |
| GSE20123 | CBR3 | 874 | 2 | 9 | 19 | |
| GSE43470 | CBR3 | 874 | 1 | 11 | 31 | |
| GSE46452 | CBR3 | 874 | 1 | 21 | 37 | |
| GSE47630 | CBR3 | 874 | 6 | 17 | 17 | |
| GSE54993 | CBR3 | 874 | 8 | 1 | 61 | |
| GSE54994 | CBR3 | 874 | 2 | 9 | 42 | |
| GSE60625 | CBR3 | 874 | 0 | 0 | 11 | |
| GSE74703 | CBR3 | 874 | 1 | 8 | 27 | |
| GSE74704 | CBR3 | 874 | 1 | 5 | 14 | |
| TCGA | CBR3 | 874 | 9 | 39 | 48 |
Total number of gains: 33; Total number of losses: 128; Total Number of normals: 327.
Somatic mutations of CBR3:
Generating mutation plots.
Highly correlated genes for CBR3:
Showing top 20/788 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBR3 | ANKRD24 | 0.768118 | 3 | 0 | 3 |
| CBR3 | RPL10L | 0.739891 | 3 | 0 | 3 |
| CBR3 | NCCRP1 | 0.724506 | 3 | 0 | 3 |
| CBR3 | PTGR1 | 0.711491 | 7 | 0 | 7 |
| CBR3 | OTOP3 | 0.70933 | 3 | 0 | 3 |
| CBR3 | TMPRSS11A | 0.680901 | 3 | 0 | 3 |
| CBR3 | UPK3B | 0.677637 | 3 | 0 | 3 |
| CBR3 | MORN3 | 0.673247 | 3 | 0 | 3 |
| CBR3 | P2RY1 | 0.670555 | 5 | 0 | 5 |
| CBR3 | TMPRSS11B | 0.670502 | 6 | 0 | 6 |
| CBR3 | SPINK7 | 0.668254 | 6 | 0 | 5 |
| CBR3 | HS3ST6 | 0.659154 | 5 | 0 | 4 |
| CBR3 | FAM214A | 0.655984 | 5 | 0 | 4 |
| CBR3 | KRTAP3-2 | 0.654437 | 4 | 0 | 4 |
| CBR3 | CYP4F3 | 0.653958 | 12 | 0 | 10 |
| CBR3 | PGD | 0.652115 | 13 | 0 | 10 |
| CBR3 | EXPH5 | 0.651937 | 11 | 0 | 11 |
| CBR3 | PPP2R5A | 0.651398 | 12 | 0 | 11 |
| CBR3 | CRB3 | 0.648652 | 5 | 0 | 5 |
| CBR3 | MUC15 | 0.645827 | 6 | 0 | 5 |
For details and further investigation, click here
