| Full name: serine peptidase inhibitor, Kazal type 7 (putative) | Alias Symbol: ECG2|ECRG2 | ||
| Type: protein-coding gene | Cytoband: 5q32 | ||
| Entrez ID: 84651 | HGNC ID: HGNC:24643 | Ensembl Gene: ENSG00000145879 | OMIM ID: 617288 |
| Drug and gene relationship at DGIdb | |||
Expression of SPINK7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPINK7 | 84651 | 223720_at | -4.6527 | 0.0420 | |
| GSE26886 | SPINK7 | 84651 | 223720_at | -7.4251 | 0.0000 | |
| GSE45670 | SPINK7 | 84651 | 223720_at | -2.4861 | 0.0154 | |
| GSE53622 | SPINK7 | 84651 | 58896 | -4.2512 | 0.0000 | |
| GSE53624 | SPINK7 | 84651 | 58896 | -4.5264 | 0.0000 | |
| GSE63941 | SPINK7 | 84651 | 223720_at | 0.1424 | 0.6592 | |
| GSE77861 | SPINK7 | 84651 | 223720_at | -4.4961 | 0.0196 | |
| GSE97050 | SPINK7 | 84651 | A_23_P213832 | -2.3078 | 0.1403 | |
| SRP007169 | SPINK7 | 84651 | RNAseq | -9.6105 | 0.0000 | |
| SRP008496 | SPINK7 | 84651 | RNAseq | -7.4291 | 0.0000 | |
| SRP064894 | SPINK7 | 84651 | RNAseq | -7.3529 | 0.0000 | |
| SRP133303 | SPINK7 | 84651 | RNAseq | -6.2763 | 0.0000 | |
| SRP159526 | SPINK7 | 84651 | RNAseq | -6.9711 | 0.0000 | |
| SRP219564 | SPINK7 | 84651 | RNAseq | -6.6284 | 0.0000 | |
| TCGA | SPINK7 | 84651 | RNAseq | -0.7642 | 0.3256 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by SPINK7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPINK7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPINK7 | 84651 | 1 | 12 | 17 | |
| GSE20123 | SPINK7 | 84651 | 1 | 13 | 16 | |
| GSE43470 | SPINK7 | 84651 | 2 | 9 | 32 | |
| GSE46452 | SPINK7 | 84651 | 0 | 27 | 32 | |
| GSE47630 | SPINK7 | 84651 | 0 | 20 | 20 | |
| GSE54993 | SPINK7 | 84651 | 9 | 1 | 60 | |
| GSE54994 | SPINK7 | 84651 | 2 | 15 | 36 | |
| GSE60625 | SPINK7 | 84651 | 0 | 0 | 11 | |
| GSE74703 | SPINK7 | 84651 | 2 | 7 | 27 | |
| GSE74704 | SPINK7 | 84651 | 1 | 8 | 11 | |
| TCGA | SPINK7 | 84651 | 5 | 38 | 53 |
Total number of gains: 23; Total number of losses: 150; Total Number of normals: 315.
Somatic mutations of SPINK7:
Generating mutation plots.
Highly correlated genes for SPINK7:
Showing top 20/1214 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPINK7 | SLURP1 | 0.935521 | 8 | 0 | 8 |
| SPINK7 | CYSRT1 | 0.935377 | 6 | 0 | 6 |
| SPINK7 | SCEL | 0.923176 | 8 | 0 | 8 |
| SPINK7 | TMPRSS11B | 0.910208 | 8 | 0 | 8 |
| SPINK7 | CRNN | 0.907325 | 8 | 0 | 8 |
| SPINK7 | VSIG10L | 0.905477 | 7 | 0 | 7 |
| SPINK7 | NCR1 | 0.904069 | 3 | 0 | 3 |
| SPINK7 | TMPRSS11E | 0.901422 | 7 | 0 | 7 |
| SPINK7 | PRSS27 | 0.897556 | 8 | 0 | 8 |
| SPINK7 | RAET1E | 0.892056 | 7 | 0 | 7 |
| SPINK7 | MAL | 0.891392 | 8 | 0 | 8 |
| SPINK7 | CXCR2 | 0.890616 | 6 | 0 | 6 |
| SPINK7 | CLCA4 | 0.885371 | 8 | 0 | 8 |
| SPINK7 | RANBP9 | 0.884568 | 6 | 0 | 6 |
| SPINK7 | MGLL | 0.882243 | 6 | 0 | 6 |
| SPINK7 | IL36A | 0.881993 | 7 | 0 | 7 |
| SPINK7 | SLC16A6 | 0.880584 | 6 | 0 | 6 |
| SPINK7 | EHD3 | 0.88036 | 6 | 0 | 6 |
| SPINK7 | KRT78 | 0.879086 | 8 | 0 | 8 |
| SPINK7 | ANXA9 | 0.878028 | 6 | 0 | 6 |
For details and further investigation, click here
