| Full name: phosphogluconate dehydrogenase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 5226 | HGNC ID: HGNC:8891 | Ensembl Gene: ENSG00000142657 | OMIM ID: 172200 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PGD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PGD | 5226 | 201118_at | -0.6758 | 0.5655 | |
| GSE20347 | PGD | 5226 | 201118_at | -1.3105 | 0.0000 | |
| GSE23400 | PGD | 5226 | 201118_at | -1.1127 | 0.0000 | |
| GSE26886 | PGD | 5226 | 201118_at | -3.3357 | 0.0000 | |
| GSE29001 | PGD | 5226 | 201118_at | -1.7587 | 0.0035 | |
| GSE38129 | PGD | 5226 | 201118_at | -0.3130 | 0.5304 | |
| GSE45670 | PGD | 5226 | 201118_at | -0.7381 | 0.0679 | |
| GSE53622 | PGD | 5226 | 70087 | -1.3175 | 0.0000 | |
| GSE53624 | PGD | 5226 | 70087 | -1.4984 | 0.0000 | |
| GSE63941 | PGD | 5226 | 201118_at | 0.8468 | 0.2482 | |
| GSE77861 | PGD | 5226 | 201118_at | -1.1584 | 0.0542 | |
| GSE97050 | PGD | 5226 | A_23_P126623 | -0.4955 | 0.5354 | |
| SRP007169 | PGD | 5226 | RNAseq | -2.3830 | 0.0000 | |
| SRP008496 | PGD | 5226 | RNAseq | -2.0489 | 0.0000 | |
| SRP064894 | PGD | 5226 | RNAseq | -1.9815 | 0.0000 | |
| SRP133303 | PGD | 5226 | RNAseq | -2.1283 | 0.0000 | |
| SRP159526 | PGD | 5226 | RNAseq | -0.5786 | 0.3029 | |
| SRP193095 | PGD | 5226 | RNAseq | -1.2479 | 0.0002 | |
| SRP219564 | PGD | 5226 | RNAseq | -1.7052 | 0.0495 | |
| TCGA | PGD | 5226 | RNAseq | 0.2522 | 0.0213 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by PGD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PGD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PGD | 5226 | 0 | 5 | 25 | |
| GSE20123 | PGD | 5226 | 0 | 3 | 27 | |
| GSE43470 | PGD | 5226 | 7 | 5 | 31 | |
| GSE46452 | PGD | 5226 | 7 | 1 | 51 | |
| GSE47630 | PGD | 5226 | 8 | 4 | 28 | |
| GSE54993 | PGD | 5226 | 3 | 1 | 66 | |
| GSE54994 | PGD | 5226 | 11 | 4 | 38 | |
| GSE60625 | PGD | 5226 | 0 | 0 | 11 | |
| GSE74703 | PGD | 5226 | 6 | 3 | 27 | |
| GSE74704 | PGD | 5226 | 0 | 0 | 20 | |
| TCGA | PGD | 5226 | 10 | 24 | 62 |
Total number of gains: 52; Total number of losses: 50; Total Number of normals: 386.
Somatic mutations of PGD:
Generating mutation plots.
Highly correlated genes for PGD:
Showing top 20/1057 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PGD | NCCRP1 | 0.809306 | 3 | 0 | 3 |
| PGD | PTGR1 | 0.779952 | 7 | 0 | 7 |
| PGD | OTOP3 | 0.768987 | 3 | 0 | 3 |
| PGD | TMPRSS11A | 0.76765 | 3 | 0 | 3 |
| PGD | ADH7 | 0.765316 | 13 | 0 | 12 |
| PGD | UPK3B | 0.737936 | 3 | 0 | 3 |
| PGD | S100A16 | 0.737833 | 7 | 0 | 6 |
| PGD | ALDH3A2 | 0.72864 | 12 | 0 | 11 |
| PGD | SMAGP | 0.727602 | 11 | 0 | 10 |
| PGD | PPL | 0.722752 | 11 | 0 | 11 |
| PGD | ALDH3A1 | 0.720324 | 13 | 0 | 13 |
| PGD | CYP4F3 | 0.720227 | 12 | 0 | 12 |
| PGD | RAB25 | 0.719188 | 11 | 0 | 10 |
| PGD | DBI | 0.718869 | 11 | 0 | 10 |
| PGD | MALL | 0.717777 | 11 | 0 | 11 |
| PGD | TALDO1 | 0.717059 | 11 | 0 | 9 |
| PGD | TPRN | 0.715089 | 6 | 0 | 6 |
| PGD | BCDIN3D | 0.710606 | 3 | 0 | 3 |
| PGD | CSTB | 0.709411 | 11 | 0 | 10 |
| PGD | TXN | 0.709196 | 12 | 0 | 12 |
For details and further investigation, click here
