| Full name: prostaglandin reductase 1 | Alias Symbol: ZADH3 | ||
| Type: protein-coding gene | Cytoband: 9q31.3 | ||
| Entrez ID: 22949 | HGNC ID: HGNC:18429 | Ensembl Gene: ENSG00000106853 | OMIM ID: 601274 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PTGR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTGR1 | 22949 | 231897_at | -1.9353 | 0.1351 | |
| GSE26886 | PTGR1 | 22949 | 231897_at | -1.8894 | 0.0000 | |
| GSE45670 | PTGR1 | 22949 | 231897_at | -0.5216 | 0.1535 | |
| GSE53622 | PTGR1 | 22949 | 146055 | -1.3349 | 0.0000 | |
| GSE53624 | PTGR1 | 22949 | 146055 | -1.1848 | 0.0000 | |
| GSE63941 | PTGR1 | 22949 | 231897_at | -1.2568 | 0.5393 | |
| GSE77861 | PTGR1 | 22949 | 231897_at | -0.9178 | 0.2440 | |
| GSE97050 | PTGR1 | 22949 | A_33_P3396444 | -0.5318 | 0.1260 | |
| SRP007169 | PTGR1 | 22949 | RNAseq | -0.7414 | 0.2794 | |
| SRP008496 | PTGR1 | 22949 | RNAseq | -0.2157 | 0.6398 | |
| SRP064894 | PTGR1 | 22949 | RNAseq | -1.1142 | 0.0001 | |
| SRP133303 | PTGR1 | 22949 | RNAseq | -2.0094 | 0.0000 | |
| SRP159526 | PTGR1 | 22949 | RNAseq | -0.6027 | 0.2183 | |
| SRP193095 | PTGR1 | 22949 | RNAseq | -0.6892 | 0.0766 | |
| SRP219564 | PTGR1 | 22949 | RNAseq | -0.6851 | 0.3852 | |
| TCGA | PTGR1 | 22949 | RNAseq | -0.0989 | 0.4292 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by PTGR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTGR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTGR1 | 22949 | 5 | 8 | 17 | |
| GSE20123 | PTGR1 | 22949 | 5 | 7 | 18 | |
| GSE43470 | PTGR1 | 22949 | 4 | 3 | 36 | |
| GSE46452 | PTGR1 | 22949 | 6 | 13 | 40 | |
| GSE47630 | PTGR1 | 22949 | 3 | 16 | 21 | |
| GSE54993 | PTGR1 | 22949 | 3 | 3 | 64 | |
| GSE54994 | PTGR1 | 22949 | 9 | 10 | 34 | |
| GSE60625 | PTGR1 | 22949 | 0 | 0 | 11 | |
| GSE74703 | PTGR1 | 22949 | 4 | 3 | 29 | |
| GSE74704 | PTGR1 | 22949 | 2 | 6 | 12 | |
| TCGA | PTGR1 | 22949 | 26 | 21 | 49 |
Total number of gains: 67; Total number of losses: 90; Total Number of normals: 331.
Somatic mutations of PTGR1:
Generating mutation plots.
Highly correlated genes for PTGR1:
Showing top 20/991 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTGR1 | MCTS1 | 0.849255 | 3 | 0 | 3 |
| PTGR1 | PKN2 | 0.813787 | 3 | 0 | 3 |
| PTGR1 | TOM1L1 | 0.791847 | 3 | 0 | 3 |
| PTGR1 | PGD | 0.779952 | 7 | 0 | 7 |
| PTGR1 | CYP4F3 | 0.766784 | 7 | 0 | 7 |
| PTGR1 | UBE2D2 | 0.761782 | 4 | 0 | 4 |
| PTGR1 | UGP2 | 0.760982 | 5 | 0 | 5 |
| PTGR1 | SDHC | 0.757787 | 3 | 0 | 3 |
| PTGR1 | HIBCH | 0.752779 | 3 | 0 | 3 |
| PTGR1 | ZNF585A | 0.749216 | 3 | 0 | 3 |
| PTGR1 | RBX1 | 0.743982 | 3 | 0 | 3 |
| PTGR1 | ALDOC | 0.739504 | 3 | 0 | 3 |
| PTGR1 | ACAA1 | 0.736359 | 3 | 0 | 3 |
| PTGR1 | IMPACT | 0.733635 | 3 | 0 | 3 |
| PTGR1 | CCNYL1 | 0.733452 | 4 | 0 | 3 |
| PTGR1 | APC | 0.732702 | 3 | 0 | 3 |
| PTGR1 | KLF3 | 0.728646 | 6 | 0 | 6 |
| PTGR1 | PRDM2 | 0.727677 | 3 | 0 | 3 |
| PTGR1 | SECISBP2L | 0.727497 | 4 | 0 | 3 |
| PTGR1 | ALDH3A2 | 0.725677 | 8 | 0 | 8 |
For details and further investigation, click here
