| Full name: alkB homolog 5, RNA demethylase | Alias Symbol: FLJ20308 | ||
| Type: protein-coding gene | Cytoband: 17p11.2 | ||
| Entrez ID: 54890 | HGNC ID: HGNC:25996 | Ensembl Gene: ENSG00000091542 | OMIM ID: 613303 |
| Drug and gene relationship at DGIdb | |||
Expression of ALKBH5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ALKBH5 | 54890 | 234302_s_at | 0.1237 | 0.7661 | |
| GSE26886 | ALKBH5 | 54890 | 234302_s_at | 0.2046 | 0.3483 | |
| GSE45670 | ALKBH5 | 54890 | 234302_s_at | 0.2296 | 0.0473 | |
| GSE53622 | ALKBH5 | 54890 | 62284 | 0.1006 | 0.1094 | |
| GSE53624 | ALKBH5 | 54890 | 62284 | 0.2903 | 0.0000 | |
| GSE63941 | ALKBH5 | 54890 | 234302_s_at | -0.1116 | 0.8805 | |
| GSE77861 | ALKBH5 | 54890 | 234302_s_at | 0.4895 | 0.0601 | |
| GSE97050 | ALKBH5 | 54890 | A_33_P3239854 | -0.0425 | 0.8686 | |
| SRP007169 | ALKBH5 | 54890 | RNAseq | 0.8628 | 0.0255 | |
| SRP008496 | ALKBH5 | 54890 | RNAseq | 1.1988 | 0.0000 | |
| SRP064894 | ALKBH5 | 54890 | RNAseq | 0.8551 | 0.0000 | |
| SRP133303 | ALKBH5 | 54890 | RNAseq | 0.4869 | 0.0000 | |
| SRP159526 | ALKBH5 | 54890 | RNAseq | 0.5576 | 0.0023 | |
| SRP193095 | ALKBH5 | 54890 | RNAseq | 0.3921 | 0.0003 | |
| SRP219564 | ALKBH5 | 54890 | RNAseq | 0.3000 | 0.4081 | |
| TCGA | ALKBH5 | 54890 | RNAseq | -0.0562 | 0.1907 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ALKBH5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ALKBH5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ALKBH5 | 54890 | 3 | 3 | 24 | |
| GSE20123 | ALKBH5 | 54890 | 3 | 4 | 23 | |
| GSE43470 | ALKBH5 | 54890 | 1 | 5 | 37 | |
| GSE46452 | ALKBH5 | 54890 | 34 | 1 | 24 | |
| GSE47630 | ALKBH5 | 54890 | 7 | 1 | 32 | |
| GSE54993 | ALKBH5 | 54890 | 3 | 3 | 64 | |
| GSE54994 | ALKBH5 | 54890 | 6 | 6 | 41 | |
| GSE60625 | ALKBH5 | 54890 | 4 | 0 | 7 | |
| GSE74703 | ALKBH5 | 54890 | 1 | 2 | 33 | |
| GSE74704 | ALKBH5 | 54890 | 2 | 1 | 17 | |
| TCGA | ALKBH5 | 54890 | 19 | 23 | 54 |
Total number of gains: 83; Total number of losses: 49; Total Number of normals: 356.
Somatic mutations of ALKBH5:
Generating mutation plots.
Highly correlated genes for ALKBH5:
Showing top 20/148 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ALKBH5 | TNFAIP8L1 | 0.801183 | 3 | 0 | 3 |
| ALKBH5 | GTF2IRD2 | 0.788962 | 3 | 0 | 3 |
| ALKBH5 | KIF4A | 0.775853 | 3 | 0 | 3 |
| ALKBH5 | KLHL26 | 0.768648 | 3 | 0 | 3 |
| ALKBH5 | NUP62CL | 0.76312 | 3 | 0 | 3 |
| ALKBH5 | SCN1B | 0.754754 | 3 | 0 | 3 |
| ALKBH5 | ZNF511 | 0.742833 | 3 | 0 | 3 |
| ALKBH5 | CDC6 | 0.738013 | 3 | 0 | 3 |
| ALKBH5 | POLD1 | 0.734863 | 3 | 0 | 3 |
| ALKBH5 | SMOC1 | 0.734857 | 3 | 0 | 3 |
| ALKBH5 | BEND3 | 0.732149 | 3 | 0 | 3 |
| ALKBH5 | SLC35G1 | 0.727475 | 4 | 0 | 3 |
| ALKBH5 | DRG2 | 0.727377 | 4 | 0 | 4 |
| ALKBH5 | POC1A | 0.725098 | 3 | 0 | 3 |
| ALKBH5 | LONP1 | 0.724522 | 3 | 0 | 3 |
| ALKBH5 | BCL2L12 | 0.72449 | 3 | 0 | 3 |
| ALKBH5 | AGPAT1 | 0.716773 | 3 | 0 | 3 |
| ALKBH5 | POLE4 | 0.71562 | 4 | 0 | 3 |
| ALKBH5 | HOXA11 | 0.710342 | 3 | 0 | 3 |
| ALKBH5 | CCDC8 | 0.70935 | 3 | 0 | 3 |
For details and further investigation, click here
