| Full name: BCL2 like 12 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 83596 | HGNC ID: HGNC:13787 | Ensembl Gene: ENSG00000126453 | OMIM ID: 610837 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of BCL2L12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BCL2L12 | 83596 | 233110_s_at | 1.0338 | 0.0559 | |
| GSE26886 | BCL2L12 | 83596 | 233110_s_at | 0.6665 | 0.0001 | |
| GSE45670 | BCL2L12 | 83596 | 233110_s_at | 0.6247 | 0.0009 | |
| GSE53622 | BCL2L12 | 83596 | 81779 | 0.4794 | 0.0000 | |
| GSE53624 | BCL2L12 | 83596 | 81779 | 0.9094 | 0.0000 | |
| GSE63941 | BCL2L12 | 83596 | 233110_s_at | 1.4872 | 0.0007 | |
| GSE77861 | BCL2L12 | 83596 | 233110_s_at | 0.2942 | 0.0871 | |
| GSE97050 | BCL2L12 | 83596 | A_33_P3244322 | 0.2325 | 0.3396 | |
| SRP007169 | BCL2L12 | 83596 | RNAseq | 0.9956 | 0.0123 | |
| SRP008496 | BCL2L12 | 83596 | RNAseq | 0.9097 | 0.0018 | |
| SRP064894 | BCL2L12 | 83596 | RNAseq | 1.1794 | 0.0000 | |
| SRP133303 | BCL2L12 | 83596 | RNAseq | 0.8352 | 0.0007 | |
| SRP159526 | BCL2L12 | 83596 | RNAseq | 1.0584 | 0.0001 | |
| SRP193095 | BCL2L12 | 83596 | RNAseq | 0.6927 | 0.0001 | |
| SRP219564 | BCL2L12 | 83596 | RNAseq | 0.8390 | 0.0245 | |
| TCGA | BCL2L12 | 83596 | RNAseq | 0.4985 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by BCL2L12 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BCL2L12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BCL2L12 | 83596 | 4 | 4 | 22 | |
| GSE20123 | BCL2L12 | 83596 | 4 | 3 | 23 | |
| GSE43470 | BCL2L12 | 83596 | 5 | 11 | 27 | |
| GSE46452 | BCL2L12 | 83596 | 45 | 1 | 13 | |
| GSE47630 | BCL2L12 | 83596 | 10 | 6 | 24 | |
| GSE54993 | BCL2L12 | 83596 | 17 | 4 | 49 | |
| GSE54994 | BCL2L12 | 83596 | 4 | 14 | 35 | |
| GSE60625 | BCL2L12 | 83596 | 9 | 0 | 2 | |
| GSE74703 | BCL2L12 | 83596 | 5 | 7 | 24 | |
| GSE74704 | BCL2L12 | 83596 | 4 | 1 | 15 | |
| TCGA | BCL2L12 | 83596 | 14 | 18 | 64 |
Total number of gains: 121; Total number of losses: 69; Total Number of normals: 298.
Somatic mutations of BCL2L12:
Generating mutation plots.
Highly correlated genes for BCL2L12:
Showing top 20/610 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BCL2L12 | MYBL2 | 0.772357 | 7 | 0 | 7 |
| BCL2L12 | OIP5 | 0.772113 | 4 | 0 | 4 |
| BCL2L12 | BMF | 0.767618 | 3 | 0 | 3 |
| BCL2L12 | EMID1 | 0.766514 | 3 | 0 | 3 |
| BCL2L12 | CDC6 | 0.765758 | 6 | 0 | 6 |
| BCL2L12 | ETV3 | 0.760127 | 3 | 0 | 3 |
| BCL2L12 | C7orf26 | 0.749852 | 3 | 0 | 3 |
| BCL2L12 | FZD9 | 0.735675 | 3 | 0 | 3 |
| BCL2L12 | CDC45 | 0.731125 | 7 | 0 | 7 |
| BCL2L12 | DUSP9 | 0.727046 | 5 | 0 | 5 |
| BCL2L12 | TKTL1 | 0.726225 | 3 | 0 | 3 |
| BCL2L12 | POLE2 | 0.726013 | 6 | 0 | 6 |
| BCL2L12 | MECR | 0.725434 | 3 | 0 | 3 |
| BCL2L12 | ALKBH5 | 0.72449 | 3 | 0 | 3 |
| BCL2L12 | POLD1 | 0.72446 | 8 | 0 | 7 |
| BCL2L12 | YKT6 | 0.724343 | 3 | 0 | 3 |
| BCL2L12 | HAUS8 | 0.722609 | 8 | 0 | 7 |
| BCL2L12 | LRR1 | 0.722521 | 7 | 0 | 7 |
| BCL2L12 | CDC20 | 0.722149 | 8 | 0 | 7 |
| BCL2L12 | ARHGAP22 | 0.718086 | 3 | 0 | 3 |
For details and further investigation, click here
