CCND3

 

Full name: cyclin D3 Alias Symbol: 
Type: protein-coding gene Cytoband: 6p21.1
Entrez ID: 896 HGNC ID: HGNC:1585 Ensembl Gene: ENSG00000112576 OMIM ID: 123834
Drug and gene relationship at DGIdb
Screen Evidence:

 

CCND3 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa04115p53 signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04310Wnt signaling pathway
hsa04390Hippo signaling pathway
hsa04510Focal adhesion
hsa04630Jak-STAT signaling pathway
hsa05162Measles
hsa05166HTLV-I infection

 

Expression of CCND3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CCND3 896 201700_at 0.2975 0.6953
GSE20347 CCND3 896 201700_at 0.1196 0.5293
GSE23400 CCND3 896 201700_at 0.1116 0.0481
GSE26886 CCND3 896 201700_at 0.0820 0.6385
GSE29001 CCND3 896 201700_at 0.0624 0.7235
GSE38129 CCND3 896 201700_at 0.0988 0.5691
GSE45670 CCND3 896 201700_at 0.1253 0.3351
GSE53622 CCND3 896 50559 -0.1959 0.0613
GSE53624 CCND3 896 50559 0.0064 0.9513
GSE63941 CCND3 896 201700_at -1.0207 0.0951
GSE77861 CCND3 896 201700_at -0.1962 0.3729
GSE97050 CCND3 896 A_23_P361773 0.0441 0.8960
SRP007169 CCND3 896 RNAseq -0.8201 0.0645
SRP008496 CCND3 896 RNAseq -0.4906 0.1352
SRP064894 CCND3 896 RNAseq 0.2352 0.4107
SRP133303 CCND3 896 RNAseq -0.0192 0.9054
SRP159526 CCND3 896 RNAseq -0.2864 0.4239
SRP193095 CCND3 896 RNAseq -0.0466 0.7139
SRP219564 CCND3 896 RNAseq -0.0047 0.9819
TCGA CCND3 896 RNAseq -0.0764 0.1360

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by CCND3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CCND3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CCND3 896 6 0 24
GSE20123 CCND3 896 6 0 24
GSE43470 CCND3 896 6 0 37
GSE46452 CCND3 896 2 9 48
GSE47630 CCND3 896 8 4 28
GSE54993 CCND3 896 3 2 65
GSE54994 CCND3 896 11 4 38
GSE60625 CCND3 896 0 1 10
GSE74703 CCND3 896 6 0 30
GSE74704 CCND3 896 3 0 17
TCGA CCND3 896 20 13 63

Total number of gains: 71; Total number of losses: 33; Total Number of normals: 384.  

 

Somatic mutations of CCND3:

 

Generating mutation plots.

 

Highly correlated genes for CCND3:

 

Showing top 20/361 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CCND3TAB10.79516303
CCND3ANKRD440.791198303
CCND3TADA30.773612303
CCND3SNX120.763858303
CCND3ADAMDEC10.753169404
CCND3PODN0.741387303
CCND3TOMM40L0.725322303
CCND3SIDT20.720958403
CCND3MFGE80.714116403
CCND3BMPR20.707897303
CCND3BAG60.707168303
CCND3CRLF10.707145303
CCND3GALNT110.705432303
CCND3CD2260.701387404
CCND3CLEC11A0.699002303
CCND3ABCG20.695846303
CCND3HEMK10.692417303
CCND3OCRL0.688814303
CCND3SLC15A30.683746504
CCND3IRF80.680336605

For details and further investigation, click here