| Full name: ATP binding cassette subfamily G member 2 (Junior blood group) | Alias Symbol: EST157481|MXR|BCRP|ABCP|CD338 | ||
| Type: protein-coding gene | Cytoband: 4q22.1 | ||
| Entrez ID: 9429 | HGNC ID: HGNC:74 | Ensembl Gene: ENSG00000118777 | OMIM ID: 603756 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ABCG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ABCG2 | 9429 | 209735_at | -0.5622 | 0.1566 | |
| GSE20347 | ABCG2 | 9429 | 209735_at | -0.1290 | 0.3441 | |
| GSE23400 | ABCG2 | 9429 | 209735_at | -0.0550 | 0.2544 | |
| GSE26886 | ABCG2 | 9429 | 209735_at | -1.2507 | 0.0001 | |
| GSE29001 | ABCG2 | 9429 | 209735_at | -0.5475 | 0.0179 | |
| GSE38129 | ABCG2 | 9429 | 209735_at | -0.3525 | 0.0185 | |
| GSE45670 | ABCG2 | 9429 | 209735_at | -0.9885 | 0.0033 | |
| GSE53622 | ABCG2 | 9429 | 92775 | -1.2383 | 0.0000 | |
| GSE53624 | ABCG2 | 9429 | 24204 | -0.5592 | 0.0002 | |
| GSE63941 | ABCG2 | 9429 | 209735_at | 0.0446 | 0.9783 | |
| GSE77861 | ABCG2 | 9429 | 209735_at | -0.1654 | 0.3061 | |
| GSE97050 | ABCG2 | 9429 | A_33_P3361067 | -0.1011 | 0.6886 | |
| SRP007169 | ABCG2 | 9429 | RNAseq | 0.7012 | 0.1437 | |
| SRP064894 | ABCG2 | 9429 | RNAseq | -0.5926 | 0.0442 | |
| SRP133303 | ABCG2 | 9429 | RNAseq | -1.2525 | 0.0000 | |
| SRP159526 | ABCG2 | 9429 | RNAseq | -0.5554 | 0.5465 | |
| SRP193095 | ABCG2 | 9429 | RNAseq | -0.5390 | 0.0567 | |
| SRP219564 | ABCG2 | 9429 | RNAseq | -0.3650 | 0.6152 | |
| TCGA | ABCG2 | 9429 | RNAseq | -0.4620 | 0.0404 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by ABCG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ABCG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ABCG2 | 9429 | 3 | 12 | 15 | |
| GSE20123 | ABCG2 | 9429 | 3 | 12 | 15 | |
| GSE43470 | ABCG2 | 9429 | 0 | 13 | 30 | |
| GSE46452 | ABCG2 | 9429 | 1 | 36 | 22 | |
| GSE47630 | ABCG2 | 9429 | 0 | 20 | 20 | |
| GSE54993 | ABCG2 | 9429 | 8 | 0 | 62 | |
| GSE54994 | ABCG2 | 9429 | 1 | 10 | 42 | |
| GSE60625 | ABCG2 | 9429 | 0 | 0 | 11 | |
| GSE74703 | ABCG2 | 9429 | 0 | 11 | 25 | |
| GSE74704 | ABCG2 | 9429 | 2 | 7 | 11 | |
| TCGA | ABCG2 | 9429 | 12 | 37 | 47 |
Total number of gains: 30; Total number of losses: 158; Total Number of normals: 300.
Somatic mutations of ABCG2:
Generating mutation plots.
Highly correlated genes for ABCG2:
Showing top 20/1061 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ABCG2 | CETN2 | 0.747787 | 3 | 0 | 3 |
| ABCG2 | PPP1R11 | 0.742279 | 3 | 0 | 3 |
| ABCG2 | NDUFA10 | 0.734357 | 3 | 0 | 3 |
| ABCG2 | DEF8 | 0.733445 | 3 | 0 | 3 |
| ABCG2 | ZNF143 | 0.725352 | 3 | 0 | 3 |
| ABCG2 | PPP2CB | 0.72196 | 3 | 0 | 3 |
| ABCG2 | USP9X | 0.718828 | 3 | 0 | 3 |
| ABCG2 | RECQL5 | 0.710148 | 3 | 0 | 3 |
| ABCG2 | FBXO8 | 0.709978 | 6 | 0 | 6 |
| ABCG2 | SLITRK4 | 0.709401 | 3 | 0 | 3 |
| ABCG2 | KDM3A | 0.704803 | 3 | 0 | 3 |
| ABCG2 | PRKAG1 | 0.704261 | 4 | 0 | 4 |
| ABCG2 | TYW3 | 0.703363 | 3 | 0 | 3 |
| ABCG2 | PPP1R3B | 0.700408 | 3 | 0 | 3 |
| ABCG2 | DLD | 0.699949 | 4 | 0 | 3 |
| ABCG2 | LTN1 | 0.697888 | 3 | 0 | 3 |
| ABCG2 | CBR4 | 0.697064 | 4 | 0 | 3 |
| ABCG2 | CCND3 | 0.695846 | 3 | 0 | 3 |
| ABCG2 | CAPZA2 | 0.693453 | 4 | 0 | 3 |
| ABCG2 | TMX3 | 0.689476 | 3 | 0 | 3 |
For details and further investigation, click here
