| Full name: milk fat globule-EGF factor 8 protein | Alias Symbol: SED1|EDIL1|BA46|OAcGD3S|HsT19888|MFG-E8|hP47 | ||
| Type: protein-coding gene | Cytoband: 15q26.1 | ||
| Entrez ID: 4240 | HGNC ID: HGNC:7036 | Ensembl Gene: ENSG00000140545 | OMIM ID: 602281 |
| Drug and gene relationship at DGIdb | |||
Expression of MFGE8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MFGE8 | 4240 | 210605_s_at | 0.0822 | 0.9367 | |
| GSE20347 | MFGE8 | 4240 | 210605_s_at | 0.2940 | 0.0589 | |
| GSE23400 | MFGE8 | 4240 | 210605_s_at | 0.1271 | 0.1278 | |
| GSE26886 | MFGE8 | 4240 | 210605_s_at | 0.5739 | 0.0000 | |
| GSE29001 | MFGE8 | 4240 | 210605_s_at | 0.1350 | 0.4994 | |
| GSE38129 | MFGE8 | 4240 | 210605_s_at | 0.1175 | 0.5478 | |
| GSE45670 | MFGE8 | 4240 | 210605_s_at | -0.1497 | 0.4011 | |
| GSE53622 | MFGE8 | 4240 | 73716 | 0.6190 | 0.0000 | |
| GSE53624 | MFGE8 | 4240 | 73716 | 0.7044 | 0.0000 | |
| GSE63941 | MFGE8 | 4240 | 210605_s_at | -1.6266 | 0.0404 | |
| GSE77861 | MFGE8 | 4240 | 210605_s_at | 0.1889 | 0.2267 | |
| GSE97050 | MFGE8 | 4240 | A_24_P133584 | 0.4348 | 0.3335 | |
| SRP007169 | MFGE8 | 4240 | RNAseq | 1.3220 | 0.0016 | |
| SRP008496 | MFGE8 | 4240 | RNAseq | 1.6186 | 0.0000 | |
| SRP064894 | MFGE8 | 4240 | RNAseq | 0.7561 | 0.0066 | |
| SRP133303 | MFGE8 | 4240 | RNAseq | 0.6867 | 0.0088 | |
| SRP159526 | MFGE8 | 4240 | RNAseq | 0.5472 | 0.1690 | |
| SRP193095 | MFGE8 | 4240 | RNAseq | 1.2463 | 0.0000 | |
| SRP219564 | MFGE8 | 4240 | RNAseq | 0.4875 | 0.3945 | |
| TCGA | MFGE8 | 4240 | RNAseq | 0.0775 | 0.2944 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by MFGE8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MFGE8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MFGE8 | 4240 | 7 | 3 | 20 | |
| GSE20123 | MFGE8 | 4240 | 7 | 3 | 20 | |
| GSE43470 | MFGE8 | 4240 | 5 | 4 | 34 | |
| GSE46452 | MFGE8 | 4240 | 3 | 7 | 49 | |
| GSE47630 | MFGE8 | 4240 | 8 | 11 | 21 | |
| GSE54993 | MFGE8 | 4240 | 4 | 6 | 60 | |
| GSE54994 | MFGE8 | 4240 | 7 | 6 | 40 | |
| GSE60625 | MFGE8 | 4240 | 4 | 0 | 7 | |
| GSE74703 | MFGE8 | 4240 | 4 | 3 | 29 | |
| GSE74704 | MFGE8 | 4240 | 4 | 2 | 14 | |
| TCGA | MFGE8 | 4240 | 17 | 11 | 68 |
Total number of gains: 70; Total number of losses: 56; Total Number of normals: 362.
Somatic mutations of MFGE8:
Generating mutation plots.
Highly correlated genes for MFGE8:
Showing top 20/1212 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MFGE8 | PSMC4 | 0.781903 | 4 | 0 | 4 |
| MFGE8 | KRTCAP2 | 0.768438 | 3 | 0 | 3 |
| MFGE8 | PRR12 | 0.76211 | 3 | 0 | 3 |
| MFGE8 | DHX37 | 0.750568 | 3 | 0 | 3 |
| MFGE8 | INPP5E | 0.73006 | 4 | 0 | 3 |
| MFGE8 | HSPG2 | 0.725019 | 12 | 0 | 12 |
| MFGE8 | SLC25A42 | 0.724391 | 3 | 0 | 3 |
| MFGE8 | C1orf122 | 0.7241 | 3 | 0 | 3 |
| MFGE8 | ACBD6 | 0.723513 | 3 | 0 | 3 |
| MFGE8 | SLC39A13 | 0.715153 | 8 | 0 | 7 |
| MFGE8 | CCND3 | 0.714116 | 4 | 0 | 3 |
| MFGE8 | SNAPC4 | 0.713731 | 4 | 0 | 4 |
| MFGE8 | ELF4 | 0.713558 | 3 | 0 | 3 |
| MFGE8 | EFEMP2 | 0.710287 | 13 | 0 | 12 |
| MFGE8 | RASGRP2 | 0.705954 | 4 | 0 | 4 |
| MFGE8 | GRWD1 | 0.701717 | 3 | 0 | 3 |
| MFGE8 | CDC42EP4 | 0.700542 | 4 | 0 | 3 |
| MFGE8 | COL6A2 | 0.694823 | 13 | 0 | 11 |
| MFGE8 | PTPN1 | 0.694221 | 3 | 0 | 3 |
| MFGE8 | MED29 | 0.690893 | 3 | 0 | 3 |
For details and further investigation, click here
