| Full name: phosphodiesterase 6B | Alias Symbol: CSNB3|rd1|RP40|CSNBAD2 | ||
| Type: protein-coding gene | Cytoband: 4p16.3 | ||
| Entrez ID: 5158 | HGNC ID: HGNC:8786 | Ensembl Gene: ENSG00000133256 | OMIM ID: 180072 |
| Drug and gene relationship at DGIdb | |||
Expression of PDE6B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDE6B | 5158 | 210304_at | 0.0260 | 0.9162 | |
| GSE20347 | PDE6B | 5158 | 210304_at | -0.0430 | 0.6391 | |
| GSE23400 | PDE6B | 5158 | 210304_at | -0.0141 | 0.6026 | |
| GSE26886 | PDE6B | 5158 | 1557777_at | -0.0117 | 0.9220 | |
| GSE29001 | PDE6B | 5158 | 210304_at | -0.0244 | 0.8698 | |
| GSE38129 | PDE6B | 5158 | 210304_at | -0.0361 | 0.6196 | |
| GSE45670 | PDE6B | 5158 | 1557777_at | -0.0669 | 0.5622 | |
| GSE53622 | PDE6B | 5158 | 103341 | 0.1761 | 0.3769 | |
| GSE53624 | PDE6B | 5158 | 103341 | -0.1540 | 0.4396 | |
| GSE63941 | PDE6B | 5158 | 1557777_at | 0.0560 | 0.6229 | |
| GSE77861 | PDE6B | 5158 | 1557777_at | -0.0195 | 0.8536 | |
| GSE97050 | PDE6B | 5158 | A_23_P10743 | 0.1644 | 0.4089 | |
| SRP064894 | PDE6B | 5158 | RNAseq | -0.2598 | 0.3083 | |
| SRP133303 | PDE6B | 5158 | RNAseq | -0.5266 | 0.0022 | |
| SRP159526 | PDE6B | 5158 | RNAseq | 0.7900 | 0.2494 | |
| SRP193095 | PDE6B | 5158 | RNAseq | 0.1426 | 0.4244 | |
| SRP219564 | PDE6B | 5158 | RNAseq | 0.3415 | 0.5922 | |
| TCGA | PDE6B | 5158 | RNAseq | 0.4204 | 0.3044 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PDE6B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDE6B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDE6B | 5158 | 0 | 17 | 13 | |
| GSE20123 | PDE6B | 5158 | 0 | 15 | 15 | |
| GSE43470 | PDE6B | 5158 | 0 | 17 | 26 | |
| GSE46452 | PDE6B | 5158 | 1 | 36 | 22 | |
| GSE47630 | PDE6B | 5158 | 3 | 19 | 18 | |
| GSE54993 | PDE6B | 5158 | 11 | 0 | 59 | |
| GSE54994 | PDE6B | 5158 | 3 | 12 | 38 | |
| GSE60625 | PDE6B | 5158 | 0 | 0 | 11 | |
| GSE74703 | PDE6B | 5158 | 0 | 13 | 23 | |
| GSE74704 | PDE6B | 5158 | 0 | 8 | 12 | |
| TCGA | PDE6B | 5158 | 9 | 47 | 40 |
Total number of gains: 27; Total number of losses: 184; Total Number of normals: 277.
Somatic mutations of PDE6B:
Generating mutation plots.
Highly correlated genes for PDE6B:
Showing top 20/179 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDE6B | FRMPD4 | 0.706487 | 3 | 0 | 3 |
| PDE6B | PLEK | 0.692994 | 3 | 0 | 3 |
| PDE6B | KCNA4 | 0.692553 | 3 | 0 | 3 |
| PDE6B | KCNH4 | 0.685498 | 3 | 0 | 3 |
| PDE6B | DDN | 0.681286 | 3 | 0 | 3 |
| PDE6B | MYBPH | 0.660173 | 4 | 0 | 4 |
| PDE6B | GBX1 | 0.647428 | 4 | 0 | 4 |
| PDE6B | RNASE2 | 0.646252 | 3 | 0 | 3 |
| PDE6B | CD244 | 0.644975 | 3 | 0 | 3 |
| PDE6B | SLIT1 | 0.633018 | 5 | 0 | 5 |
| PDE6B | CD33 | 0.627206 | 3 | 0 | 3 |
| PDE6B | TP53I11 | 0.621302 | 3 | 0 | 3 |
| PDE6B | APOBEC1 | 0.621201 | 3 | 0 | 3 |
| PDE6B | HORMAD2 | 0.612906 | 3 | 0 | 3 |
| PDE6B | P2RY10 | 0.612247 | 3 | 0 | 3 |
| PDE6B | TNFSF8 | 0.611782 | 5 | 0 | 4 |
| PDE6B | CNR2 | 0.610682 | 4 | 0 | 3 |
| PDE6B | NEUROD4 | 0.609409 | 5 | 0 | 3 |
| PDE6B | LYPLA2 | 0.608073 | 3 | 0 | 3 |
| PDE6B | STMN2 | 0.606709 | 4 | 0 | 4 |
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