| Full name: gamma-aminobutyric acid type A receptor gamma2 subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q34 | ||
| Entrez ID: 2566 | HGNC ID: HGNC:4087 | Ensembl Gene: ENSG00000113327 | OMIM ID: 137164 |
| Drug and gene relationship at DGIdb | |||
GABRG2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa05032 | Morphine addiction |
Expression of GABRG2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRG2 | 2566 | 206849_at | 0.3647 | 0.3002 | |
| GSE20347 | GABRG2 | 2566 | 206849_at | 0.0873 | 0.2757 | |
| GSE23400 | GABRG2 | 2566 | 206849_at | -0.0702 | 0.1831 | |
| GSE26886 | GABRG2 | 2566 | 206849_at | -0.0482 | 0.6525 | |
| GSE29001 | GABRG2 | 2566 | 206849_at | -0.0873 | 0.6517 | |
| GSE38129 | GABRG2 | 2566 | 206849_at | 0.0455 | 0.6312 | |
| GSE45670 | GABRG2 | 2566 | 206849_at | 0.2416 | 0.1172 | |
| GSE53622 | GABRG2 | 2566 | 81401 | -0.0639 | 0.7699 | |
| GSE53624 | GABRG2 | 2566 | 81401 | -0.0245 | 0.8968 | |
| GSE63941 | GABRG2 | 2566 | 206849_at | 0.3180 | 0.6135 | |
| GSE77861 | GABRG2 | 2566 | 206849_at | 0.0413 | 0.7748 | |
| GSE97050 | GABRG2 | 2566 | A_32_P25514 | -0.0240 | 0.9128 | |
| TCGA | GABRG2 | 2566 | RNAseq | -0.2361 | 0.8150 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GABRG2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GABRG2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRG2 | 2566 | 0 | 12 | 18 | |
| GSE20123 | GABRG2 | 2566 | 0 | 12 | 18 | |
| GSE43470 | GABRG2 | 2566 | 2 | 10 | 31 | |
| GSE46452 | GABRG2 | 2566 | 0 | 27 | 32 | |
| GSE47630 | GABRG2 | 2566 | 0 | 20 | 20 | |
| GSE54993 | GABRG2 | 2566 | 9 | 2 | 59 | |
| GSE54994 | GABRG2 | 2566 | 2 | 15 | 36 | |
| GSE60625 | GABRG2 | 2566 | 0 | 0 | 11 | |
| GSE74703 | GABRG2 | 2566 | 2 | 8 | 26 | |
| GSE74704 | GABRG2 | 2566 | 0 | 7 | 13 | |
| TCGA | GABRG2 | 2566 | 6 | 37 | 53 |
Total number of gains: 21; Total number of losses: 150; Total Number of normals: 317.
Somatic mutations of GABRG2:
Generating mutation plots.
Highly correlated genes for GABRG2:
Showing top 20/420 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRG2 | NHLH1 | 0.685677 | 3 | 0 | 3 |
| GABRG2 | OR1G1 | 0.679056 | 3 | 0 | 3 |
| GABRG2 | C8A | 0.674261 | 6 | 0 | 6 |
| GABRG2 | CACNB1 | 0.669919 | 5 | 0 | 5 |
| GABRG2 | ZPBP | 0.662321 | 4 | 0 | 4 |
| GABRG2 | NAA11 | 0.662318 | 4 | 0 | 4 |
| GABRG2 | RBP4 | 0.661681 | 3 | 0 | 3 |
| GABRG2 | CHIT1 | 0.661504 | 3 | 0 | 3 |
| GABRG2 | COLEC10 | 0.657135 | 4 | 0 | 4 |
| GABRG2 | ADAM30 | 0.654048 | 4 | 0 | 3 |
| GABRG2 | CD244 | 0.651058 | 3 | 0 | 3 |
| GABRG2 | SGK2 | 0.648359 | 4 | 0 | 3 |
| GABRG2 | IFNA10 | 0.648049 | 4 | 0 | 4 |
| GABRG2 | SHOX | 0.640361 | 3 | 0 | 3 |
| GABRG2 | UMOD | 0.640072 | 3 | 0 | 3 |
| GABRG2 | TMEM151B | 0.639662 | 4 | 0 | 4 |
| GABRG2 | MASP2 | 0.639152 | 4 | 0 | 4 |
| GABRG2 | DNMT3L | 0.637945 | 4 | 0 | 4 |
| GABRG2 | BCAN | 0.635987 | 6 | 0 | 5 |
| GABRG2 | SLC6A5 | 0.635185 | 4 | 0 | 3 |
For details and further investigation, click here
