| Full name: DNA nucleotidylexotransferase | Alias Symbol: TDT | ||
| Type: protein-coding gene | Cytoband: 10q24.1 | ||
| Entrez ID: 1791 | HGNC ID: HGNC:2983 | Ensembl Gene: ENSG00000107447 | OMIM ID: 187410 |
| Drug and gene relationship at DGIdb | |||
Expression of DNTT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNTT | 1791 | 1566363_at | -0.2184 | 0.4320 | |
| GSE20347 | DNTT | 1791 | 210487_at | -0.1157 | 0.1090 | |
| GSE23400 | DNTT | 1791 | 210487_at | -0.1722 | 0.0000 | |
| GSE26886 | DNTT | 1791 | 1566363_at | -0.2603 | 0.0107 | |
| GSE29001 | DNTT | 1791 | 210487_at | -0.1756 | 0.1107 | |
| GSE38129 | DNTT | 1791 | 210487_at | -0.0953 | 0.2026 | |
| GSE45670 | DNTT | 1791 | 1566363_at | -0.1008 | 0.2688 | |
| GSE53622 | DNTT | 1791 | 27776 | -0.1262 | 0.0059 | |
| GSE53624 | DNTT | 1791 | 27776 | -0.0114 | 0.9180 | |
| GSE63941 | DNTT | 1791 | 1566363_at | -0.6795 | 0.0009 | |
| GSE77861 | DNTT | 1791 | 1566363_at | -0.3017 | 0.0372 | |
| SRP159526 | DNTT | 1791 | RNAseq | -1.2941 | 0.0154 | |
| TCGA | DNTT | 1791 | RNAseq | 1.3358 | 0.5604 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DNTT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNTT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNTT | 1791 | 0 | 8 | 22 | |
| GSE20123 | DNTT | 1791 | 0 | 7 | 23 | |
| GSE43470 | DNTT | 1791 | 0 | 7 | 36 | |
| GSE46452 | DNTT | 1791 | 0 | 11 | 48 | |
| GSE47630 | DNTT | 1791 | 2 | 14 | 24 | |
| GSE54993 | DNTT | 1791 | 7 | 0 | 63 | |
| GSE54994 | DNTT | 1791 | 2 | 10 | 41 | |
| GSE60625 | DNTT | 1791 | 0 | 0 | 11 | |
| GSE74703 | DNTT | 1791 | 0 | 5 | 31 | |
| GSE74704 | DNTT | 1791 | 0 | 4 | 16 | |
| TCGA | DNTT | 1791 | 5 | 28 | 63 |
Total number of gains: 16; Total number of losses: 94; Total Number of normals: 378.
Somatic mutations of DNTT:
Generating mutation plots.
Highly correlated genes for DNTT:
Showing top 20/687 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNTT | C8orf48 | 0.722201 | 3 | 0 | 3 |
| DNTT | ZNF582 | 0.706792 | 3 | 0 | 3 |
| DNTT | IL1RAPL2 | 0.703862 | 3 | 0 | 3 |
| DNTT | APBB1IP | 0.69676 | 3 | 0 | 3 |
| DNTT | ATP6V1G2 | 0.69555 | 4 | 0 | 4 |
| DNTT | CRYBB1 | 0.693965 | 3 | 0 | 3 |
| DNTT | RNASE7 | 0.687744 | 3 | 0 | 3 |
| DNTT | CHRM2 | 0.687105 | 4 | 0 | 4 |
| DNTT | CCDC87 | 0.686475 | 3 | 0 | 3 |
| DNTT | OR2H2 | 0.6855 | 4 | 0 | 4 |
| DNTT | GK2 | 0.685409 | 3 | 0 | 3 |
| DNTT | CCR4 | 0.682826 | 3 | 0 | 3 |
| DNTT | SYAP1 | 0.676064 | 4 | 0 | 4 |
| DNTT | RNF17 | 0.675167 | 3 | 0 | 3 |
| DNTT | CRP | 0.674633 | 4 | 0 | 4 |
| DNTT | ULK3 | 0.673814 | 3 | 0 | 3 |
| DNTT | SLC4A4 | 0.673131 | 4 | 0 | 3 |
| DNTT | CD244 | 0.669967 | 4 | 0 | 3 |
| DNTT | ATG9B | 0.669687 | 4 | 0 | 3 |
| DNTT | CCDC30 | 0.66771 | 3 | 0 | 3 |
For details and further investigation, click here
