| Full name: cyclin dependent kinase 8 | Alias Symbol: K35 | ||
| Type: protein-coding gene | Cytoband: 13q12.13 | ||
| Entrez ID: 1024 | HGNC ID: HGNC:1779 | Ensembl Gene: ENSG00000132964 | OMIM ID: 603184 |
| Drug and gene relationship at DGIdb | |||
Expression of CDK8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CDK8 | 1024 | 204831_at | -0.0257 | 0.9768 | |
| GSE20347 | CDK8 | 1024 | 204831_at | -0.6155 | 0.0008 | |
| GSE23400 | CDK8 | 1024 | 204831_at | -0.0191 | 0.7786 | |
| GSE26886 | CDK8 | 1024 | 204831_at | -0.5013 | 0.0251 | |
| GSE29001 | CDK8 | 1024 | 204831_at | -0.2807 | 0.3626 | |
| GSE38129 | CDK8 | 1024 | 204831_at | -0.3560 | 0.0389 | |
| GSE45670 | CDK8 | 1024 | 204831_at | -0.1304 | 0.3650 | |
| GSE53622 | CDK8 | 1024 | 66659 | -0.3917 | 0.0000 | |
| GSE53624 | CDK8 | 1024 | 66659 | -0.3130 | 0.0000 | |
| GSE63941 | CDK8 | 1024 | 204831_at | -0.2117 | 0.6244 | |
| GSE77861 | CDK8 | 1024 | 204831_at | -0.1042 | 0.8010 | |
| GSE97050 | CDK8 | 1024 | A_33_P3264780 | -0.4060 | 0.2151 | |
| SRP007169 | CDK8 | 1024 | RNAseq | -1.0338 | 0.0046 | |
| SRP008496 | CDK8 | 1024 | RNAseq | -0.7579 | 0.0044 | |
| SRP064894 | CDK8 | 1024 | RNAseq | -0.0009 | 0.9944 | |
| SRP133303 | CDK8 | 1024 | RNAseq | -0.0471 | 0.7854 | |
| SRP159526 | CDK8 | 1024 | RNAseq | -0.4542 | 0.1092 | |
| SRP193095 | CDK8 | 1024 | RNAseq | -0.5148 | 0.0000 | |
| SRP219564 | CDK8 | 1024 | RNAseq | -0.5916 | 0.0134 | |
| TCGA | CDK8 | 1024 | RNAseq | -0.1569 | 0.0095 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CDK8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CDK8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CDK8 | 1024 | 1 | 13 | 16 | |
| GSE20123 | CDK8 | 1024 | 1 | 12 | 17 | |
| GSE43470 | CDK8 | 1024 | 2 | 12 | 29 | |
| GSE46452 | CDK8 | 1024 | 0 | 33 | 26 | |
| GSE47630 | CDK8 | 1024 | 3 | 26 | 11 | |
| GSE54993 | CDK8 | 1024 | 11 | 2 | 57 | |
| GSE54994 | CDK8 | 1024 | 1 | 13 | 39 | |
| GSE60625 | CDK8 | 1024 | 0 | 3 | 8 | |
| GSE74703 | CDK8 | 1024 | 2 | 9 | 25 | |
| GSE74704 | CDK8 | 1024 | 0 | 10 | 10 | |
| TCGA | CDK8 | 1024 | 6 | 44 | 46 |
Total number of gains: 27; Total number of losses: 177; Total Number of normals: 284.
Somatic mutations of CDK8:
Generating mutation plots.
Highly correlated genes for CDK8:
Showing top 20/350 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CDK8 | ZNF570 | 0.768287 | 3 | 0 | 3 |
| CDK8 | PHF20 | 0.736617 | 3 | 0 | 3 |
| CDK8 | KIAA0586 | 0.735114 | 3 | 0 | 3 |
| CDK8 | RBBP6 | 0.730704 | 3 | 0 | 3 |
| CDK8 | TADA1 | 0.723949 | 4 | 0 | 4 |
| CDK8 | CDADC1 | 0.715944 | 3 | 0 | 3 |
| CDK8 | MRPS21 | 0.712288 | 3 | 0 | 3 |
| CDK8 | LZIC | 0.70918 | 4 | 0 | 3 |
| CDK8 | RAB21 | 0.700566 | 3 | 0 | 3 |
| CDK8 | TMEM51 | 0.693163 | 3 | 0 | 3 |
| CDK8 | YTHDF2 | 0.690148 | 3 | 0 | 3 |
| CDK8 | SRP9 | 0.69001 | 3 | 0 | 3 |
| CDK8 | ARHGAP1 | 0.688952 | 3 | 0 | 3 |
| CDK8 | ZBTB34 | 0.68826 | 3 | 0 | 3 |
| CDK8 | SLC25A3 | 0.683387 | 3 | 0 | 3 |
| CDK8 | ATG2B | 0.682353 | 4 | 0 | 4 |
| CDK8 | WWP1 | 0.680204 | 3 | 0 | 3 |
| CDK8 | DIMT1 | 0.680181 | 3 | 0 | 3 |
| CDK8 | CGGBP1 | 0.679374 | 3 | 0 | 3 |
| CDK8 | ZNF304 | 0.673411 | 3 | 0 | 3 |
For details and further investigation, click here
