| Full name: RB binding protein 6, ubiquitin ligase | Alias Symbol: P2P-R|PACT|SNAMA | ||
| Type: protein-coding gene | Cytoband: 16p12.1 | ||
| Entrez ID: 5930 | HGNC ID: HGNC:9889 | Ensembl Gene: ENSG00000122257 | OMIM ID: 600938 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of RBBP6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RBBP6 | 5930 | 212781_at | 0.0167 | 0.9731 | |
| GSE20347 | RBBP6 | 5930 | 205178_s_at | 0.1333 | 0.2838 | |
| GSE23400 | RBBP6 | 5930 | 212783_at | -0.0389 | 0.5599 | |
| GSE26886 | RBBP6 | 5930 | 212783_at | 0.7135 | 0.0146 | |
| GSE29001 | RBBP6 | 5930 | 205178_s_at | -0.0060 | 0.9890 | |
| GSE38129 | RBBP6 | 5930 | 205178_s_at | -0.0321 | 0.7915 | |
| GSE45670 | RBBP6 | 5930 | 212781_at | 0.1144 | 0.1892 | |
| GSE53622 | RBBP6 | 5930 | 121371 | 0.0312 | 0.5756 | |
| GSE53624 | RBBP6 | 5930 | 121371 | 0.0522 | 0.2567 | |
| GSE63941 | RBBP6 | 5930 | 205178_s_at | -0.3455 | 0.2405 | |
| GSE77861 | RBBP6 | 5930 | 212781_at | -0.1255 | 0.5692 | |
| GSE97050 | RBBP6 | 5930 | A_23_P342053 | 0.0410 | 0.9046 | |
| SRP007169 | RBBP6 | 5930 | RNAseq | -0.4363 | 0.2742 | |
| SRP008496 | RBBP6 | 5930 | RNAseq | -0.1114 | 0.6779 | |
| SRP064894 | RBBP6 | 5930 | RNAseq | -0.4369 | 0.0007 | |
| SRP133303 | RBBP6 | 5930 | RNAseq | 0.0779 | 0.5654 | |
| SRP159526 | RBBP6 | 5930 | RNAseq | 0.3403 | 0.0766 | |
| SRP193095 | RBBP6 | 5930 | RNAseq | 0.0452 | 0.5883 | |
| SRP219564 | RBBP6 | 5930 | RNAseq | -0.3685 | 0.1722 | |
| TCGA | RBBP6 | 5930 | RNAseq | -0.0246 | 0.5887 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RBBP6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RBBP6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RBBP6 | 5930 | 4 | 4 | 22 | |
| GSE20123 | RBBP6 | 5930 | 4 | 3 | 23 | |
| GSE43470 | RBBP6 | 5930 | 4 | 3 | 36 | |
| GSE46452 | RBBP6 | 5930 | 38 | 1 | 20 | |
| GSE47630 | RBBP6 | 5930 | 11 | 6 | 23 | |
| GSE54993 | RBBP6 | 5930 | 3 | 5 | 62 | |
| GSE54994 | RBBP6 | 5930 | 4 | 9 | 40 | |
| GSE60625 | RBBP6 | 5930 | 4 | 0 | 7 | |
| GSE74703 | RBBP6 | 5930 | 4 | 2 | 30 | |
| GSE74704 | RBBP6 | 5930 | 2 | 1 | 17 | |
| TCGA | RBBP6 | 5930 | 19 | 13 | 64 |
Total number of gains: 97; Total number of losses: 47; Total Number of normals: 344.
Somatic mutations of RBBP6:
Generating mutation plots.
Highly correlated genes for RBBP6:
Showing top 20/329 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RBBP6 | NKAP | 0.793705 | 3 | 0 | 3 |
| RBBP6 | HMGN1 | 0.79023 | 3 | 0 | 3 |
| RBBP6 | MRPL20 | 0.785026 | 3 | 0 | 3 |
| RBBP6 | KLHDC10 | 0.782009 | 3 | 0 | 3 |
| RBBP6 | GNPTAB | 0.772826 | 3 | 0 | 3 |
| RBBP6 | LATS1 | 0.771921 | 3 | 0 | 3 |
| RBBP6 | PROSER1 | 0.769447 | 3 | 0 | 3 |
| RBBP6 | INTS4 | 0.763133 | 3 | 0 | 3 |
| RBBP6 | RBM4 | 0.762235 | 3 | 0 | 3 |
| RBBP6 | CCNY | 0.755153 | 3 | 0 | 3 |
| RBBP6 | OSBPL9 | 0.752695 | 4 | 0 | 4 |
| RBBP6 | SBF2 | 0.746073 | 3 | 0 | 3 |
| RBBP6 | GLT8D1 | 0.744554 | 3 | 0 | 3 |
| RBBP6 | RNF13 | 0.742231 | 3 | 0 | 3 |
| RBBP6 | CMTM6 | 0.742226 | 3 | 0 | 3 |
| RBBP6 | FAF2 | 0.740441 | 4 | 0 | 3 |
| RBBP6 | GUSB | 0.739771 | 4 | 0 | 4 |
| RBBP6 | RFNG | 0.737365 | 3 | 0 | 3 |
| RBBP6 | SGMS1 | 0.732516 | 4 | 0 | 3 |
| RBBP6 | CDK8 | 0.730704 | 3 | 0 | 3 |
For details and further investigation, click here
