| Full name: mitochondrial ribosomal protein S21 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q21.2 | ||
| Entrez ID: 54460 | HGNC ID: HGNC:14046 | Ensembl Gene: ENSG00000266472 | OMIM ID: 611984 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MRPS21:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MRPS21 | 54460 | 222997_s_at | -0.0032 | 0.9966 | |
| GSE26886 | MRPS21 | 54460 | 222997_s_at | 0.6520 | 0.0011 | |
| GSE45670 | MRPS21 | 54460 | 222997_s_at | 0.0100 | 0.9620 | |
| GSE53622 | MRPS21 | 54460 | 8959 | -0.0062 | 0.9127 | |
| GSE53624 | MRPS21 | 54460 | 8959 | 0.1469 | 0.0067 | |
| GSE63941 | MRPS21 | 54460 | 222997_s_at | 0.0355 | 0.9512 | |
| GSE77861 | MRPS21 | 54460 | 222997_s_at | -0.1289 | 0.7370 | |
| GSE97050 | MRPS21 | 54460 | A_23_P86182 | -0.6858 | 0.1291 | |
| SRP007169 | MRPS21 | 54460 | RNAseq | -1.0516 | 0.0024 | |
| SRP008496 | MRPS21 | 54460 | RNAseq | -0.8788 | 0.0077 | |
| SRP064894 | MRPS21 | 54460 | RNAseq | 0.0910 | 0.7603 | |
| SRP133303 | MRPS21 | 54460 | RNAseq | -0.2047 | 0.2674 | |
| SRP159526 | MRPS21 | 54460 | RNAseq | 0.1737 | 0.1263 | |
| SRP193095 | MRPS21 | 54460 | RNAseq | -0.2704 | 0.0227 | |
| SRP219564 | MRPS21 | 54460 | RNAseq | -0.4535 | 0.0978 | |
| TCGA | MRPS21 | 54460 | RNAseq | 0.1526 | 0.0279 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by MRPS21 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MRPS21:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MRPS21 | 54460 | 15 | 0 | 15 | |
| GSE20123 | MRPS21 | 54460 | 15 | 0 | 15 | |
| GSE43470 | MRPS21 | 54460 | 6 | 1 | 36 | |
| GSE46452 | MRPS21 | 54460 | 2 | 1 | 56 | |
| GSE47630 | MRPS21 | 54460 | 14 | 0 | 26 | |
| GSE54993 | MRPS21 | 54460 | 0 | 3 | 67 | |
| GSE54994 | MRPS21 | 54460 | 15 | 0 | 38 | |
| GSE60625 | MRPS21 | 54460 | 0 | 0 | 11 | |
| GSE74703 | MRPS21 | 54460 | 6 | 1 | 29 | |
| GSE74704 | MRPS21 | 54460 | 7 | 0 | 13 | |
| TCGA | MRPS21 | 54460 | 38 | 2 | 56 |
Total number of gains: 118; Total number of losses: 8; Total Number of normals: 362.
Somatic mutations of MRPS21:
Generating mutation plots.
Highly correlated genes for MRPS21:
Showing top 20/139 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MRPS21 | DVL1 | 0.749762 | 3 | 0 | 3 |
| MRPS21 | GPATCH1 | 0.743591 | 3 | 0 | 3 |
| MRPS21 | NDUFB1 | 0.739522 | 4 | 0 | 3 |
| MRPS21 | SLC25A28 | 0.727341 | 3 | 0 | 3 |
| MRPS21 | MRFAP1 | 0.726967 | 3 | 0 | 3 |
| MRPS21 | EIF5B | 0.726385 | 3 | 0 | 3 |
| MRPS21 | EIF3H | 0.722833 | 3 | 0 | 3 |
| MRPS21 | FIP1L1 | 0.712901 | 3 | 0 | 3 |
| MRPS21 | NPHP3 | 0.712873 | 3 | 0 | 3 |
| MRPS21 | CDK8 | 0.712288 | 3 | 0 | 3 |
| MRPS21 | MYH3 | 0.712051 | 3 | 0 | 3 |
| MRPS21 | RPL24 | 0.712017 | 4 | 0 | 3 |
| MRPS21 | MRPS6 | 0.708924 | 3 | 0 | 3 |
| MRPS21 | SURF6 | 0.707291 | 3 | 0 | 3 |
| MRPS21 | CDC73 | 0.703325 | 3 | 0 | 3 |
| MRPS21 | BBS9 | 0.702748 | 3 | 0 | 3 |
| MRPS21 | MMP15 | 0.699808 | 3 | 0 | 3 |
| MRPS21 | TRMT61A | 0.698409 | 3 | 0 | 3 |
| MRPS21 | EVI5L | 0.697886 | 3 | 0 | 3 |
| MRPS21 | OGFOD1 | 0.693652 | 3 | 0 | 3 |
For details and further investigation, click here
