| Full name: pleckstrin homology domain containing A3 | Alias Symbol: FAPP1 | ||
| Type: protein-coding gene | Cytoband: 2q31.2 | ||
| Entrez ID: 65977 | HGNC ID: HGNC:14338 | Ensembl Gene: ENSG00000116095 | OMIM ID: 607774 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHA3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHA3 | 65977 | 223370_at | 0.4204 | 0.5092 | |
| GSE26886 | PLEKHA3 | 65977 | 223370_at | 1.6413 | 0.0000 | |
| GSE45670 | PLEKHA3 | 65977 | 223370_at | -0.0437 | 0.8750 | |
| GSE53622 | PLEKHA3 | 65977 | 66729 | 0.1987 | 0.1557 | |
| GSE53624 | PLEKHA3 | 65977 | 66729 | 0.5941 | 0.0000 | |
| GSE63941 | PLEKHA3 | 65977 | 223370_at | -0.7839 | 0.1627 | |
| GSE77861 | PLEKHA3 | 65977 | 223370_at | 0.7414 | 0.0020 | |
| GSE97050 | PLEKHA3 | 65977 | A_23_P102412 | -0.2795 | 0.4469 | |
| SRP007169 | PLEKHA3 | 65977 | RNAseq | 1.1232 | 0.0024 | |
| SRP008496 | PLEKHA3 | 65977 | RNAseq | 1.0074 | 0.0000 | |
| SRP064894 | PLEKHA3 | 65977 | RNAseq | 0.2294 | 0.2341 | |
| SRP133303 | PLEKHA3 | 65977 | RNAseq | 0.2945 | 0.0525 | |
| SRP159526 | PLEKHA3 | 65977 | RNAseq | 0.0822 | 0.7178 | |
| SRP193095 | PLEKHA3 | 65977 | RNAseq | 0.4069 | 0.0106 | |
| SRP219564 | PLEKHA3 | 65977 | RNAseq | -0.1629 | 0.7143 | |
| TCGA | PLEKHA3 | 65977 | RNAseq | -0.2251 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by PLEKHA3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHA3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHA3 | 65977 | 7 | 0 | 23 | |
| GSE20123 | PLEKHA3 | 65977 | 7 | 0 | 23 | |
| GSE43470 | PLEKHA3 | 65977 | 5 | 1 | 37 | |
| GSE46452 | PLEKHA3 | 65977 | 1 | 4 | 54 | |
| GSE47630 | PLEKHA3 | 65977 | 4 | 4 | 32 | |
| GSE54993 | PLEKHA3 | 65977 | 0 | 5 | 65 | |
| GSE54994 | PLEKHA3 | 65977 | 11 | 4 | 38 | |
| GSE60625 | PLEKHA3 | 65977 | 0 | 3 | 8 | |
| GSE74703 | PLEKHA3 | 65977 | 4 | 1 | 31 | |
| GSE74704 | PLEKHA3 | 65977 | 4 | 0 | 16 | |
| TCGA | PLEKHA3 | 65977 | 27 | 6 | 63 |
Total number of gains: 70; Total number of losses: 28; Total Number of normals: 390.
Somatic mutations of PLEKHA3:
Generating mutation plots.
Highly correlated genes for PLEKHA3:
Showing top 20/1092 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHA3 | PTPN4 | 0.858411 | 3 | 0 | 3 |
| PLEKHA3 | TRRAP | 0.857282 | 3 | 0 | 3 |
| PLEKHA3 | ALKBH6 | 0.842926 | 3 | 0 | 3 |
| PLEKHA3 | MYO5A | 0.822345 | 3 | 0 | 3 |
| PLEKHA3 | PHIP | 0.802706 | 4 | 0 | 4 |
| PLEKHA3 | TRA2B | 0.799737 | 3 | 0 | 3 |
| PLEKHA3 | WIZ | 0.797199 | 3 | 0 | 3 |
| PLEKHA3 | WDR81 | 0.796062 | 4 | 0 | 4 |
| PLEKHA3 | SLC44A1 | 0.7951 | 3 | 0 | 3 |
| PLEKHA3 | CELF1 | 0.788816 | 3 | 0 | 3 |
| PLEKHA3 | SRRT | 0.783316 | 3 | 0 | 3 |
| PLEKHA3 | ABCC1 | 0.781744 | 3 | 0 | 3 |
| PLEKHA3 | STAT2 | 0.777854 | 3 | 0 | 3 |
| PLEKHA3 | STRADA | 0.774071 | 3 | 0 | 3 |
| PLEKHA3 | PACSIN2 | 0.771124 | 3 | 0 | 3 |
| PLEKHA3 | CPNE8 | 0.770937 | 3 | 0 | 3 |
| PLEKHA3 | LINC00674 | 0.764338 | 4 | 0 | 3 |
| PLEKHA3 | CDKN1C | 0.763908 | 3 | 0 | 3 |
| PLEKHA3 | ANKRD10 | 0.761132 | 5 | 0 | 5 |
| PLEKHA3 | MAPKAPK5 | 0.754867 | 3 | 0 | 3 |
For details and further investigation, click here
