| Full name: programmed cell death 4 | Alias Symbol: H731 | ||
| Type: protein-coding gene | Cytoband: 10q25.2 | ||
| Entrez ID: 27250 | HGNC ID: HGNC:8763 | Ensembl Gene: ENSG00000150593 | OMIM ID: 608610 |
| Drug and gene relationship at DGIdb | |||
PDCD4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of PDCD4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDCD4 | 27250 | 1557166_at | -0.9452 | 0.2503 | |
| GSE26886 | PDCD4 | 27250 | 1557166_at | 0.2040 | 0.1353 | |
| GSE45670 | PDCD4 | 27250 | 1557166_at | -1.0636 | 0.0000 | |
| GSE63941 | PDCD4 | 27250 | 1557166_at | 0.3445 | 0.4337 | |
| GSE77861 | PDCD4 | 27250 | 1557166_at | -0.1603 | 0.0656 | |
| GSE97050 | PDCD4 | 27250 | A_33_P3212092 | -0.9122 | 0.0672 | |
| SRP007169 | PDCD4 | 27250 | RNAseq | -1.9902 | 0.0000 | |
| SRP008496 | PDCD4 | 27250 | RNAseq | -1.6359 | 0.0000 | |
| SRP064894 | PDCD4 | 27250 | RNAseq | -2.0213 | 0.0000 | |
| SRP133303 | PDCD4 | 27250 | RNAseq | -1.8274 | 0.0000 | |
| SRP159526 | PDCD4 | 27250 | RNAseq | -2.1086 | 0.0000 | |
| SRP193095 | PDCD4 | 27250 | RNAseq | -1.6923 | 0.0000 | |
| TCGA | PDCD4 | 27250 | RNAseq | -0.4187 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by PDCD4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of PDCD4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDCD4 | 27250 | 1 | 9 | 20 | |
| GSE20123 | PDCD4 | 27250 | 1 | 8 | 21 | |
| GSE43470 | PDCD4 | 27250 | 0 | 7 | 36 | |
| GSE46452 | PDCD4 | 27250 | 0 | 11 | 48 | |
| GSE47630 | PDCD4 | 27250 | 2 | 14 | 24 | |
| GSE54993 | PDCD4 | 27250 | 8 | 0 | 62 | |
| GSE54994 | PDCD4 | 27250 | 1 | 10 | 42 | |
| GSE60625 | PDCD4 | 27250 | 0 | 0 | 11 | |
| GSE74703 | PDCD4 | 27250 | 0 | 5 | 31 | |
| GSE74704 | PDCD4 | 27250 | 1 | 4 | 15 | |
| TCGA | PDCD4 | 27250 | 4 | 29 | 63 |
Total number of gains: 18; Total number of losses: 97; Total Number of normals: 373.
Somatic mutations of PDCD4:
Generating mutation plots.
Highly correlated genes for PDCD4:
Showing top 20/376 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDCD4 | GRHPR | 0.815527 | 3 | 0 | 3 |
| PDCD4 | RABGAP1 | 0.814001 | 3 | 0 | 3 |
| PDCD4 | SNTB1 | 0.811339 | 3 | 0 | 3 |
| PDCD4 | PTBP2 | 0.807048 | 3 | 0 | 3 |
| PDCD4 | RAB9B | 0.802707 | 3 | 0 | 3 |
| PDCD4 | KLF9 | 0.788758 | 3 | 0 | 3 |
| PDCD4 | DNAJC28 | 0.785904 | 3 | 0 | 3 |
| PDCD4 | FOXO3 | 0.764771 | 3 | 0 | 3 |
| PDCD4 | ST6GALNAC6 | 0.762494 | 4 | 0 | 4 |
| PDCD4 | TMEM220 | 0.760691 | 4 | 0 | 4 |
| PDCD4 | PRKAA2 | 0.760064 | 3 | 0 | 3 |
| PDCD4 | CDKN1C | 0.758187 | 3 | 0 | 3 |
| PDCD4 | EZH1 | 0.755852 | 3 | 0 | 3 |
| PDCD4 | TMEM132C | 0.754993 | 3 | 0 | 3 |
| PDCD4 | CKMT2 | 0.754505 | 4 | 0 | 4 |
| PDCD4 | WLS | 0.754099 | 3 | 0 | 3 |
| PDCD4 | KAT6B | 0.752197 | 3 | 0 | 3 |
| PDCD4 | PCP4 | 0.749736 | 3 | 0 | 3 |
| PDCD4 | NR3C2 | 0.747082 | 3 | 0 | 3 |
| PDCD4 | FRA10AC1 | 0.744791 | 3 | 0 | 3 |
For details and further investigation, click here
