| Full name: ceramide synthase 6 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 2q24.3 | ||
| Entrez ID: 253782 | HGNC ID: HGNC:23826 | Ensembl Gene: ENSG00000172292 | OMIM ID: 615336 |
| Drug and gene relationship at DGIdb | |||
Expression of CERS6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CERS6 | 253782 | 212442_s_at | 0.5634 | 0.1541 | |
| GSE20347 | CERS6 | 253782 | 212442_s_at | 0.0976 | 0.6186 | |
| GSE23400 | CERS6 | 253782 | 212442_s_at | 0.3449 | 0.0000 | |
| GSE26886 | CERS6 | 253782 | 212446_s_at | 0.4401 | 0.0995 | |
| GSE29001 | CERS6 | 253782 | 212442_s_at | 0.2281 | 0.5080 | |
| GSE38129 | CERS6 | 253782 | 212442_s_at | 0.4130 | 0.0106 | |
| GSE45670 | CERS6 | 253782 | 212442_s_at | 0.2114 | 0.3259 | |
| GSE53622 | CERS6 | 253782 | 47747 | 0.4748 | 0.0000 | |
| GSE53624 | CERS6 | 253782 | 47747 | 0.8677 | 0.0000 | |
| GSE63941 | CERS6 | 253782 | 212442_s_at | 1.6376 | 0.0100 | |
| GSE77861 | CERS6 | 253782 | 212442_s_at | 0.3429 | 0.2798 | |
| GSE97050 | CERS6 | 253782 | A_32_P5480 | -0.1385 | 0.6835 | |
| SRP007169 | CERS6 | 253782 | RNAseq | 1.2328 | 0.0089 | |
| SRP008496 | CERS6 | 253782 | RNAseq | 1.5365 | 0.0000 | |
| SRP064894 | CERS6 | 253782 | RNAseq | 0.3407 | 0.1149 | |
| SRP133303 | CERS6 | 253782 | RNAseq | 0.8135 | 0.0016 | |
| SRP159526 | CERS6 | 253782 | RNAseq | 0.5336 | 0.0731 | |
| SRP193095 | CERS6 | 253782 | RNAseq | -0.2330 | 0.1470 | |
| SRP219564 | CERS6 | 253782 | RNAseq | -0.0485 | 0.8890 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by CERS6 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of CERS6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CERS6 | 253782 | 6 | 0 | 24 | |
| GSE20123 | CERS6 | 253782 | 6 | 0 | 24 | |
| GSE43470 | CERS6 | 253782 | 5 | 1 | 37 | |
| GSE46452 | CERS6 | 253782 | 1 | 4 | 54 | |
| GSE47630 | CERS6 | 253782 | 5 | 3 | 32 | |
| GSE54993 | CERS6 | 253782 | 0 | 5 | 65 | |
| GSE54994 | CERS6 | 253782 | 11 | 2 | 40 | |
| GSE60625 | CERS6 | 253782 | 0 | 3 | 8 | |
| GSE74703 | CERS6 | 253782 | 4 | 1 | 31 | |
| GSE74704 | CERS6 | 253782 | 3 | 0 | 17 | |
| TCGA | CERS6 | 253782 | 24 | 10 | 62 |
Total number of gains: 65; Total number of losses: 29; Total Number of normals: 394.
Somatic mutations of CERS6:
Generating mutation plots.
Highly correlated genes for CERS6:
Showing top 20/313 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CERS6 | RNF166 | 0.690586 | 3 | 0 | 3 |
| CERS6 | ZNF451 | 0.681011 | 3 | 0 | 3 |
| CERS6 | SLFNL1 | 0.667337 | 3 | 0 | 3 |
| CERS6 | RIMKLB | 0.661049 | 3 | 0 | 3 |
| CERS6 | ARHGEF2 | 0.656049 | 3 | 0 | 3 |
| CERS6 | PHOSPHO2 | 0.646228 | 5 | 0 | 5 |
| CERS6 | FAM91A1 | 0.64488 | 5 | 0 | 4 |
| CERS6 | ZNF280C | 0.640901 | 6 | 0 | 5 |
| CERS6 | QSOX2 | 0.632202 | 5 | 0 | 4 |
| CERS6 | ZNF260 | 0.631494 | 4 | 0 | 4 |
| CERS6 | ANKRD23 | 0.626892 | 4 | 0 | 3 |
| CERS6 | ACSL1 | 0.625571 | 3 | 0 | 3 |
| CERS6 | CHCHD7 | 0.620101 | 4 | 0 | 4 |
| CERS6 | NPHP3 | 0.614612 | 3 | 0 | 3 |
| CERS6 | UBE2Q1 | 0.613874 | 4 | 0 | 3 |
| CERS6 | KCTD15 | 0.607781 | 3 | 0 | 3 |
| CERS6 | HSF2 | 0.605737 | 4 | 0 | 3 |
| CERS6 | FEM1A | 0.605364 | 3 | 0 | 3 |
| CERS6 | SERPINI1 | 0.603971 | 4 | 0 | 3 |
| CERS6 | ABI2 | 0.601948 | 3 | 0 | 3 |
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