| Full name: acyl-CoA synthetase long chain family member 1 | Alias Symbol: LACS2|LACS|ACS1|LACS1|FACL1 | ||
| Type: protein-coding gene | Cytoband: 4q35.1 | ||
| Entrez ID: 2180 | HGNC ID: HGNC:3569 | Ensembl Gene: ENSG00000151726 | OMIM ID: 152425 |
| Drug and gene relationship at DGIdb | |||
ACSL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03320 | PPAR signaling pathway | |
| hsa04920 | Adipocytokine signaling pathway |
Expression of ACSL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACSL1 | 2180 | 201963_at | 0.5888 | 0.4558 | |
| GSE20347 | ACSL1 | 2180 | 201963_at | -0.5842 | 0.0091 | |
| GSE23400 | ACSL1 | 2180 | 207275_s_at | -0.1237 | 0.1677 | |
| GSE26886 | ACSL1 | 2180 | 201963_at | -0.6715 | 0.0234 | |
| GSE29001 | ACSL1 | 2180 | 201963_at | -0.1075 | 0.8565 | |
| GSE38129 | ACSL1 | 2180 | 201963_at | -0.5271 | 0.0089 | |
| GSE45670 | ACSL1 | 2180 | 201963_at | 0.0904 | 0.7095 | |
| GSE53622 | ACSL1 | 2180 | 121848 | -0.3027 | 0.0059 | |
| GSE53624 | ACSL1 | 2180 | 121848 | -0.2548 | 0.0022 | |
| GSE63941 | ACSL1 | 2180 | 201963_at | 0.1429 | 0.8601 | |
| GSE77861 | ACSL1 | 2180 | 201963_at | -0.1007 | 0.8390 | |
| GSE97050 | ACSL1 | 2180 | A_23_P110212 | -0.1912 | 0.4082 | |
| SRP007169 | ACSL1 | 2180 | RNAseq | 0.0644 | 0.8698 | |
| SRP008496 | ACSL1 | 2180 | RNAseq | -0.1348 | 0.6266 | |
| SRP064894 | ACSL1 | 2180 | RNAseq | -0.0312 | 0.9070 | |
| SRP133303 | ACSL1 | 2180 | RNAseq | 0.1550 | 0.4657 | |
| SRP159526 | ACSL1 | 2180 | RNAseq | 0.2130 | 0.6680 | |
| SRP193095 | ACSL1 | 2180 | RNAseq | -0.0873 | 0.5563 | |
| SRP219564 | ACSL1 | 2180 | RNAseq | 0.4858 | 0.2231 | |
| TCGA | ACSL1 | 2180 | RNAseq | -0.1578 | 0.0210 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ACSL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACSL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACSL1 | 2180 | 3 | 13 | 14 | |
| GSE20123 | ACSL1 | 2180 | 3 | 13 | 14 | |
| GSE43470 | ACSL1 | 2180 | 1 | 12 | 30 | |
| GSE46452 | ACSL1 | 2180 | 1 | 36 | 22 | |
| GSE47630 | ACSL1 | 2180 | 0 | 22 | 18 | |
| GSE54993 | ACSL1 | 2180 | 10 | 0 | 60 | |
| GSE54994 | ACSL1 | 2180 | 2 | 12 | 39 | |
| GSE60625 | ACSL1 | 2180 | 0 | 0 | 11 | |
| GSE74703 | ACSL1 | 2180 | 1 | 9 | 26 | |
| GSE74704 | ACSL1 | 2180 | 1 | 6 | 13 | |
| TCGA | ACSL1 | 2180 | 11 | 32 | 53 |
Total number of gains: 33; Total number of losses: 155; Total Number of normals: 300.
Somatic mutations of ACSL1:
Generating mutation plots.
Highly correlated genes for ACSL1:
Showing top 20/290 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACSL1 | CHCHD7 | 0.823465 | 3 | 0 | 3 |
| ACSL1 | SCML4 | 0.792617 | 3 | 0 | 3 |
| ACSL1 | YPEL2 | 0.783547 | 3 | 0 | 3 |
| ACSL1 | FBXO28 | 0.762803 | 3 | 0 | 3 |
| ACSL1 | NR2C2 | 0.752183 | 3 | 0 | 3 |
| ACSL1 | CELF1 | 0.74852 | 3 | 0 | 3 |
| ACSL1 | AGGF1 | 0.74714 | 3 | 0 | 3 |
| ACSL1 | GIN1 | 0.746151 | 3 | 0 | 3 |
| ACSL1 | DENND4C | 0.728478 | 4 | 0 | 4 |
| ACSL1 | BTBD7 | 0.728252 | 5 | 0 | 5 |
| ACSL1 | DCUN1D4 | 0.725995 | 3 | 0 | 3 |
| ACSL1 | PROSER1 | 0.723608 | 3 | 0 | 3 |
| ACSL1 | IMMP1L | 0.721419 | 3 | 0 | 3 |
| ACSL1 | PPIP5K2 | 0.715373 | 3 | 0 | 3 |
| ACSL1 | MRFAP1 | 0.714846 | 3 | 0 | 3 |
| ACSL1 | UBA2 | 0.713051 | 3 | 0 | 3 |
| ACSL1 | POLI | 0.712625 | 3 | 0 | 3 |
| ACSL1 | ZNF7 | 0.709113 | 3 | 0 | 3 |
| ACSL1 | FNBP1 | 0.709074 | 4 | 0 | 3 |
| ACSL1 | GCC2 | 0.704491 | 3 | 0 | 3 |
For details and further investigation, click here
