Full name: CF transmembrane conductance regulator	Alias Symbol: MRP7|ABC35|TNR-CFTR|dJ760C5.1|CFTR/MRP
Type: protein-coding gene	Cytoband: 7q31.2
Entrez ID: 1080	HGNC ID: HGNC:1884	Ensembl Gene: ENSG00000001626	OMIM ID: 602421
Drug and gene relationship at DGIdb

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CFTR involved pathways:

KEGG pathway	Description	View
hsa04024	cAMP signaling pathway	View
hsa04152	AMPK signaling pathway	View
hsa04972	Pancreatic secretion	View
hsa04976	Bile secretion	View
hsa05110	Vibrio cholerae infection	View

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Expression of CFTR:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	CFTR	1080	205043_at	-0.2846	0.4570	Show
GSE20347	CFTR	1080	205043_at	-0.3044	0.0011	Show
GSE23400	CFTR	1080	217026_at	-0.0434	0.1941	Show
GSE26886	CFTR	1080	205043_at	-0.1016	0.8916	Show
GSE29001	CFTR	1080	205043_at	-1.2069	0.0000	Show
GSE38129	CFTR	1080	205043_at	-0.4046	0.0007	Show
GSE45670	CFTR	1080	205043_at	-0.1957	0.4914	Show
GSE53622	CFTR	1080	79420	-1.6586	0.0000	Show
GSE53624	CFTR	1080	79420	-3.2351	0.0000	Show
GSE63941	CFTR	1080	205043_at	-1.6218	0.0017	Show
GSE77861	CFTR	1080	205043_at	-0.0312	0.8603	Show
SRP064894	CFTR	1080	RNAseq	-0.8978	0.2049	Show
SRP133303	CFTR	1080	RNAseq	-0.1548	0.8655	Show
SRP159526	CFTR	1080	RNAseq	-1.7258	0.0079	Show
TCGA	CFTR	1080	RNAseq	-1.1913	0.0699	Show

Upregulated datasets: 0; Downregulated datasets: 5.  Download Data

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Survival by CFTR expression:

 

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Copy number change of CFTR:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	CFTR	1080	8	2	20	Show
GSE20123	CFTR	1080	9	2	19	Show
GSE43470	CFTR	1080	4	2	37	Show
GSE46452	CFTR	1080	8	1	50	Show
GSE47630	CFTR	1080	7	4	29	Show
GSE54993	CFTR	1080	2	7	61	Show
GSE54994	CFTR	1080	12	5	36	Show
GSE60625	CFTR	1080	0	0	11	Show
GSE74703	CFTR	1080	4	2	30	Show
GSE74704	CFTR	1080	6	2	12	Show
TCGA	CFTR	1080	33	17	46	Show

Total number of gains: 93; Total number of losses: 44; Total Number of normals: 351.  Download Data

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Somatic mutations of CFTR:

 

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Highly correlated genes for CFTR:

 

Showing top 20/631 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
CFTR	SLITRK4	0.715123	3	0	3
CFTR	SCNN1B	0.681303	7	0	7
CFTR	CYP2C9	0.680155	7	0	6
CFTR	CEACAM5	0.670091	7	0	6
CFTR	SCUBE3	0.668912	3	0	3
CFTR	YOD1	0.666663	6	0	5
CFTR	CTTNBP2	0.662633	5	0	5
CFTR	MID2	0.662578	4	0	4
CFTR	BPIFB1	0.662188	5	0	4
CFTR	PF4	0.661946	3	0	3
CFTR	ATP10B	0.660511	7	0	6
CFTR	CYP2J2	0.658328	6	0	5
CFTR	GDPD3	0.657285	7	0	5
CFTR	CWH43	0.656106	5	0	4
CFTR	CXCR5	0.653609	3	0	3
CFTR	CHST9	0.652973	4	0	4
CFTR	DHRS9	0.652004	5	0	5
CFTR	GOLPH3L	0.65164	6	0	6
CFTR	CYP2C18	0.650333	7	0	6
CFTR	PCDH1	0.649927	6	0	6

For details and further investigation, click here