| Full name: cytochrome P450 family 2 subfamily C member 18 | Alias Symbol: P450IIC17|CPCI|CYP2C | ||
| Type: protein-coding gene | Cytoband: 10q23.33 | ||
| Entrez ID: 1562 | HGNC ID: HGNC:2620 | Ensembl Gene: ENSG00000108242 | OMIM ID: 601131 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP2C18:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP2C18 | 1562 | 208126_s_at | -2.6994 | 0.0642 | |
| GSE20347 | CYP2C18 | 1562 | 208126_s_at | -2.8377 | 0.0000 | |
| GSE23400 | CYP2C18 | 1562 | 208126_s_at | -1.7316 | 0.0000 | |
| GSE26886 | CYP2C18 | 1562 | 208126_s_at | -4.2653 | 0.0000 | |
| GSE29001 | CYP2C18 | 1562 | 208126_s_at | -2.6515 | 0.0000 | |
| GSE38129 | CYP2C18 | 1562 | 208126_s_at | -2.1170 | 0.0000 | |
| GSE45670 | CYP2C18 | 1562 | 208126_s_at | -0.9159 | 0.0958 | |
| GSE53622 | CYP2C18 | 1562 | 82034 | -2.9128 | 0.0000 | |
| GSE53624 | CYP2C18 | 1562 | 82034 | -3.3528 | 0.0000 | |
| GSE63941 | CYP2C18 | 1562 | 208126_s_at | -0.0358 | 0.9386 | |
| GSE77861 | CYP2C18 | 1562 | 208126_s_at | -1.7433 | 0.0296 | |
| SRP007169 | CYP2C18 | 1562 | RNAseq | -3.1853 | 0.0000 | |
| SRP008496 | CYP2C18 | 1562 | RNAseq | -3.2567 | 0.0000 | |
| SRP064894 | CYP2C18 | 1562 | RNAseq | -2.7119 | 0.0000 | |
| SRP133303 | CYP2C18 | 1562 | RNAseq | -2.3469 | 0.0001 | |
| SRP159526 | CYP2C18 | 1562 | RNAseq | -3.3130 | 0.0004 | |
| SRP193095 | CYP2C18 | 1562 | RNAseq | -2.3465 | 0.0000 | |
| SRP219564 | CYP2C18 | 1562 | RNAseq | -3.4760 | 0.0049 | |
| TCGA | CYP2C18 | 1562 | RNAseq | -0.7869 | 0.0451 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by CYP2C18 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP2C18:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP2C18 | 1562 | 1 | 8 | 21 | |
| GSE20123 | CYP2C18 | 1562 | 1 | 7 | 22 | |
| GSE43470 | CYP2C18 | 1562 | 0 | 7 | 36 | |
| GSE46452 | CYP2C18 | 1562 | 0 | 11 | 48 | |
| GSE47630 | CYP2C18 | 1562 | 2 | 14 | 24 | |
| GSE54993 | CYP2C18 | 1562 | 7 | 0 | 63 | |
| GSE54994 | CYP2C18 | 1562 | 2 | 10 | 41 | |
| GSE60625 | CYP2C18 | 1562 | 0 | 0 | 11 | |
| GSE74703 | CYP2C18 | 1562 | 0 | 5 | 31 | |
| GSE74704 | CYP2C18 | 1562 | 0 | 4 | 16 | |
| TCGA | CYP2C18 | 1562 | 6 | 26 | 64 |
Total number of gains: 19; Total number of losses: 92; Total Number of normals: 377.
Somatic mutations of CYP2C18:
Generating mutation plots.
Highly correlated genes for CYP2C18:
Showing top 20/1652 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP2C18 | TMPRSS11E | 0.83978 | 10 | 0 | 10 |
| CYP2C18 | ABLIM1 | 0.836409 | 11 | 0 | 10 |
| CYP2C18 | ATP13A4 | 0.833923 | 7 | 0 | 7 |
| CYP2C18 | PPL | 0.83133 | 11 | 0 | 11 |
| CYP2C18 | EVPL | 0.830493 | 10 | 0 | 10 |
| CYP2C18 | ENDOU | 0.829162 | 10 | 0 | 10 |
| CYP2C18 | TGM3 | 0.82904 | 11 | 0 | 11 |
| CYP2C18 | SASH1 | 0.818992 | 10 | 0 | 10 |
| CYP2C18 | SMIM5 | 0.818531 | 6 | 0 | 6 |
| CYP2C18 | SCEL | 0.818334 | 11 | 0 | 11 |
| CYP2C18 | GBP6 | 0.817413 | 5 | 0 | 5 |
| CYP2C18 | ECM1 | 0.816522 | 10 | 0 | 10 |
| CYP2C18 | KRT78 | 0.812251 | 6 | 0 | 6 |
| CYP2C18 | C5orf66-AS1 | 0.805626 | 6 | 0 | 6 |
| CYP2C18 | RAB10 | 0.804516 | 6 | 0 | 6 |
| CYP2C18 | EPS8L2 | 0.8039 | 10 | 0 | 10 |
| CYP2C18 | BLNK | 0.803379 | 10 | 0 | 10 |
| CYP2C18 | GLTP | 0.798472 | 9 | 0 | 8 |
| CYP2C18 | PRSS2 | 0.796626 | 8 | 0 | 8 |
| CYP2C18 | GDPD3 | 0.796509 | 11 | 0 | 10 |
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