| Full name: cytochrome P450 family 2 subfamily C member 9 | Alias Symbol: P450IIC9 | ||
| Type: protein-coding gene | Cytoband: 10q23.33 | ||
| Entrez ID: 1559 | HGNC ID: HGNC:2623 | Ensembl Gene: ENSG00000138109 | OMIM ID: 601130 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP2C9:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP2C9 | 1559 | 220017_x_at | -1.3747 | 0.1835 | |
| GSE20347 | CYP2C9 | 1559 | 216025_x_at | -1.1727 | 0.0000 | |
| GSE23400 | CYP2C9 | 1559 | 220017_x_at | -0.6514 | 0.0000 | |
| GSE26886 | CYP2C9 | 1559 | 220017_x_at | -2.3275 | 0.0000 | |
| GSE29001 | CYP2C9 | 1559 | 220017_x_at | -1.9979 | 0.0000 | |
| GSE38129 | CYP2C9 | 1559 | 220017_x_at | -1.2324 | 0.0002 | |
| GSE45670 | CYP2C9 | 1559 | 220017_x_at | -1.0922 | 0.0385 | |
| GSE53622 | CYP2C9 | 1559 | 20100 | -2.7044 | 0.0000 | |
| GSE53624 | CYP2C9 | 1559 | 20100 | -3.7655 | 0.0000 | |
| GSE63941 | CYP2C9 | 1559 | 220017_x_at | 0.2992 | 0.0533 | |
| GSE77861 | CYP2C9 | 1559 | 220017_x_at | -0.6429 | 0.3133 | |
| SRP064894 | CYP2C9 | 1559 | RNAseq | -2.3362 | 0.0000 | |
| SRP133303 | CYP2C9 | 1559 | RNAseq | -1.8978 | 0.0000 | |
| SRP159526 | CYP2C9 | 1559 | RNAseq | -3.5551 | 0.0000 | |
| SRP193095 | CYP2C9 | 1559 | RNAseq | -1.5345 | 0.0001 | |
| TCGA | CYP2C9 | 1559 | RNAseq | -2.0285 | 0.0044 |
Upregulated datasets: 0; Downregulated datasets: 12.
Survival by CYP2C9 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP2C9:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP2C9 | 1559 | 1 | 8 | 21 | |
| GSE20123 | CYP2C9 | 1559 | 1 | 7 | 22 | |
| GSE43470 | CYP2C9 | 1559 | 0 | 7 | 36 | |
| GSE46452 | CYP2C9 | 1559 | 0 | 11 | 48 | |
| GSE47630 | CYP2C9 | 1559 | 2 | 14 | 24 | |
| GSE54993 | CYP2C9 | 1559 | 7 | 0 | 63 | |
| GSE54994 | CYP2C9 | 1559 | 2 | 10 | 41 | |
| GSE60625 | CYP2C9 | 1559 | 0 | 0 | 11 | |
| GSE74703 | CYP2C9 | 1559 | 0 | 5 | 31 | |
| GSE74704 | CYP2C9 | 1559 | 0 | 4 | 16 | |
| TCGA | CYP2C9 | 1559 | 6 | 26 | 64 |
Total number of gains: 19; Total number of losses: 92; Total Number of normals: 377.
Somatic mutations of CYP2C9:
Generating mutation plots.
Highly correlated genes for CYP2C9:
Showing top 20/1375 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP2C9 | CYP2C18 | 0.796127 | 12 | 0 | 10 |
| CYP2C9 | ARHGAP27 | 0.792347 | 6 | 0 | 6 |
| CYP2C9 | ATP10B | 0.790766 | 9 | 0 | 8 |
| CYP2C9 | PLEKHM1 | 0.789224 | 10 | 0 | 10 |
| CYP2C9 | ST6GALNAC1 | 0.785804 | 6 | 0 | 6 |
| CYP2C9 | EPS8L1 | 0.784284 | 10 | 0 | 10 |
| CYP2C9 | EPS8L2 | 0.782301 | 10 | 0 | 10 |
| CYP2C9 | ZNF185 | 0.779236 | 10 | 0 | 10 |
| CYP2C9 | TTC22 | 0.777933 | 10 | 0 | 10 |
| CYP2C9 | MAL | 0.777763 | 10 | 0 | 10 |
| CYP2C9 | GYS2 | 0.776908 | 9 | 0 | 9 |
| CYP2C9 | CLCA4 | 0.771872 | 10 | 0 | 10 |
| CYP2C9 | SPINK7 | 0.770631 | 6 | 0 | 6 |
| CYP2C9 | TTC9 | 0.770013 | 10 | 0 | 9 |
| CYP2C9 | ABLIM1 | 0.769924 | 11 | 0 | 11 |
| CYP2C9 | TMPRSS11E | 0.769254 | 10 | 0 | 10 |
| CYP2C9 | ENDOU | 0.767145 | 10 | 0 | 10 |
| CYP2C9 | CYSRT1 | 0.766926 | 6 | 0 | 6 |
| CYP2C9 | TMPRSS11B | 0.766452 | 6 | 0 | 6 |
| CYP2C9 | CRNN | 0.766394 | 10 | 0 | 10 |
For details and further investigation, click here
